Subclinical enthesitis in nail psoriasis patients: a case‐control study

JDDG - Journal of the German Society of Dermatology - Tập 15 Số 4 - Trang 405-412 - 2017
Karlijn M.G. Klaassen1, Marieke J.M. Ploegmakers2, P.C.M. van de Kerkhof1, Willemijn M. Klein2, Marcel C. Pasch1
1Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands
2Department of Radiology, Radboud University Medical Center, Nijmegen, the Netherlands

Tóm tắt

SummaryBackgroundPatients with nail psoriasis have a higher prevalence of psoriatic arthritis; however, the pathogenetic relationship between these two disorders is as yet unclear. Entheses have been suggested as disease epicenter, which might explain the pathogenesis on an anatomical level.ObjectiveTo contribute to the elucidation of the hypothesis as regards the anatomical link between nail psoriasis and psoriatic arthritis, with the extensor enthesis of the distal interphalangeal joint as the epicenter.MethodsWe conducted a cross‐sectional cohort study, visualizing the distal interphalangeal (DIP) joints entheses of patients with fingernail psoriasis (n = 54), psoriasis patients without nail involvement (n = 32), and healthy controls (n = 32) using three‐dimensional ultrasound. Patients with nail psoriasis underwent repeat imaging studies after one year.ResultsIndividuals with nail psoriasis had significantly thicker radial entheses than psoriasis patients without nail involvement. However, there were no significant differences in entheseal thickness between adjacent nails that were affected and those that were not (1.297 mm vs. 1.253 mm, p = 0.13). Follow‐up after one year showed no significant differences in entheseal thickness in correlation with nail psoriasis activity.ConclusionsThe present study provides evidence for subclinical enthesitis at the level of the DIP joint in patients with nail psoriasis. However, an anatomical correlation between nail psoriasis and psoriatic arthritis could not be confirmed.

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Parts of this article (placed between quotation marks) were previous published in the following thesis: K. Klaassen. Unraveling nail psoriasis. Nail psoriasis and psoriatic arthritis; 6: 135–148.

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JDDG - Journal of the German Society of Dermatology

Tập 15 Số 4

405-412

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