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Xuất huyết dưới nhện kích hoạt tình trạng viêm thần kinh trên toàn bộ vỏ não, dẫn đến cái chết của tế bào thần kinh
Tóm tắt
Xuất huyết dưới nhện (SAH) là một căn bệnh nghiêm trọng, với tổn thương não sớm (EBI) xảy ra trong vòng 72 giờ sau khi bị chấn thương SAH, góp phần vào tiên lượng kém của bệnh. EBI là một hiện tượng phức tạp liên quan đến nhiều cơ chế khác nhau. Mặc dù tình trạng viêm thần kinh đã được chứng minh là một yếu tố tiên lượng quan trọng của EBI, nhưng liệu tình trạng viêm thần kinh có lan rộng khắp vỏ não và mức độ sâu của nó trong vỏ não thì vẫn chưa rõ ràng. Hiểu biết về cách tình trạng viêm lan tỏa khắp vỏ não cũng quan trọng để xác định liệu các tác nhân chống viêm có thể là một chiến lược điều trị trong tương lai cho EBI hay không. Trong nghiên cứu này, chúng tôi đã gây SAH ở chuột bằng cách tiêm máu tụ vào khoang trước giao thoa thị giác và tạo ra các mô hình từ nhẹ đến nặng của SAH. Trong các mẫu cắt ngang vỏ não của chuột, chúng tôi đã điều tra tình trạng viêm thần kinh và cái chết của tế bào thần kinh ở vùng vỏ não xa nơi tiêm máu tụ, từ vùng trước đến vùng sau, sau 24 giờ kể từ khi bị thương SAH. Tình trạng viêm thần kinh do SAH đã lan ra tất cả các lớp của vỏ não từ phần trước đến phần sau của vỏ não thông qua sự xâm nhập của vi cầu thần kinh đã kích hoạt, và cái chết tế bào thần kinh tăng lên tương ứng với tình trạng viêm thần kinh. Xu hướng này gia tăng theo mức độ nghiêm trọng của bệnh. Tình trạng viêm thần kinh do SAH đã lan rộng ra khắp vỏ não, gây ra cái chết của tế bào thần kinh. Xét rằng vỏ não là nơi chịu trách nhiệm cho trí nhớ dài hạn và chuyển động, việc ức chế tình trạng viêm thần kinh ở tất cả các lớp của vỏ não có thể cải thiện tiên lượng của bệnh nhân mắc SAH.
Từ khóa
#Xuất huyết dưới nhện #tổn thương não sớm #viêm thần kinh #tế bào thần kinh #vỏ nãoTài liệu tham khảo
Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017;389:655–66.
Neifert SN, Chapman EK, Martini ML, Shuman WH, Schupper AJ, Oermann EK, et al. Aneurysmal subarachnoid hemorrhage: the last decade. Transl Stroke Res. 2021;12:428–46.
Nieuwkamp DJ, Setz LE, Algra A, Linn FHH, de Rooij NK, Rinkel GJE. Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol. 2009;8:635–42.
Etminan N, Chang HS, Hackenberg K, de Rooij NK, Vergouwen MDI, Rinkel GJE, et al. Worldwide incidence of aneurysmal subarachnoid hemorrhage according to region, time period, blood pressure, and smoking prevalence in the population. JAMA Neurol. 2019;76:588–97.
van Gijn J, Kerr RS, Rinkel GJE. Subarachnoid haemorrhage. Lancet. 2007;369:306–18.
Gonçalves B, Turon R, Mendes A, Melo N, Lacerda P, Brasil P, et al. Effect of early brain infarction after subarachnoid hemorrhage: a systematic review and meta-analysis. World Neurosurg. 2018;115:e292–8.
Caner B, Hou J, Altay O, Fuj M, Zhang JH. Transition of research focus from vasospasm to early brain injury after subarachnoid hemorrhage. J Neurochem. 2012;123:12–21.
Fujii M, Yan J, Rolland WB, Soejima Y, Caner B, Zhang JH. Early brain injury, an evolving frontier in subarachnoid hemorrhage research. Transl Stroke Res. 2013;4:432–46.
Chou SHY, Feske SK, Simmons SL, Konigsberg RGJ, Orzell SC, Marckmann A, et al. Elevated peripheral neutrophils and matrix metalloproteinase 9 as biomarkers of functional outcome following subarachnoid hemorrhage. Transl Stroke Res. 2011;2:600–7.
Li Y, Wu P, Bihl JC, Shi H. Underlying mechanisms and potential therapeutic molecular targets in blood-brain barrier disruption after subarachnoid hemorrhage. Curr Neuropharmacol. 2020;18:1168–79.
Han SM, Wan H, Kudo G, Foltz WD, Vines DC, Green DE, et al. Molecular alterations in the hippocampus after experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014;34:108–17.
Sehba FA, Pluta RM, Zhang JH. Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol. 2011;43:27–40.
Tso MK, Turgeon P, Bosche B, Lee CK, Nie T, D’Abbondanza J, et al. Gene expression profiling of brain endothelial cells after experimental subarachnoid haemorrhage. Sci Rep. 2021;11:7818.
Geraghty JR, Davis JL, Testai FD. Neuroinflammation and microvascular dysfunction after experimental subarachnoid hemorrhage: emerging components of early brain injury related to outcome. Neurocrit Care. 2019;31:373–89.
Sun CM, Enkhjargal B, Reis C, Zhou KR, Xie ZY, Wu LY, et al. Osteopontin attenuates early brain injury through regulating autophagy-apoptosis interaction after subarachnoid hemorrhage in rats. CNS Neurosci Ther. 2019;25:1162–72.
Pan P, Xu L, Zhang H, Liu Y, Lu X, Chen G, et al. A review of hematoma components clearance mechanism after subarachnoid hemorrhage. Front Neurosci. 2020;14:685.
Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Doré S. Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage. J Neuroinflammation. 2016;13:26.
Wong GC, Chen J, Zheng Z, Lu G, Chan W, Zhang Y. Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage. Neural Regen Res. 2022;17:1404–11.
Zeyu Z, Yuanjian F, Cameron L, Sheng C. The role of immune inflammation in aneurysmal subarachnoid hemorrhage. Exp Neurol. 2021;336:113535.
Zheng VZ, Wong GKC. Neuroinflammation responses after subarachnoid hemorrhage: a review. J Clin Neurosci. 2017;42:7–11.
Peng J, Wu Y, Tian X, Pang J, Kuai L, Cao F, et al. High-throughput sequencing and co-expression network analysis of lncRNAs and mRNAs in early brain injury following experimental subarachnoid haemorrhage. Sci Rep. 2017;7:46577.
Ito D, Imai Y, Ohsawa K, Nakajima K, Fukuuchi Y, Kohsaka S. Microglia-specific localisation of a novel calcium binding protein, Iba1. Brain Res Mol Brain Res. 1998;57:1–9.
Wen YR, Tan PH, Cheng JK, Liu YC, Ji RR. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011;110:487–94.
Zheng ZV, Lyu H, Lam SYE, Lam PK, Poon WS, Wong GKC. The dynamics of microglial polarization reveal the resident neuroinflammatory responses after subarachnoid hemorrhage. Transl Stroke Res. 2020;11:433–49.
Hinwood M, Morandini J, Day TA, Walker FR. Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex. Cereb Cortex. 2012;22:1442–54.
Morizawa YM, Hirayama Y, Ohno N, Shibata S, Shigetomi E, Sui Y, et al. Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway. Nat Commun. 2017;8:28.
Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, et al. Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y 1 receptor downregulation. Cell Rep. 2017;19:1151–64.
Pekny M, Pekna M. Astrocyte reactivity and reactive astrogliosis: costs and benefits. Physiol Rev. 2014;94:1077–98.
Wu Y, Pang J, Peng J, Cao F, Guo Z, Jiang L, et al. Apolipoprotein E deficiency aggravates neuronal injury by enhancing neuroinflammation via the JNK/c-jun pathway in the early phase of experimental subarachnoid hemorrhage in mice. Oxid Med Cell Longev. 2019;2019:3832648.
Yuan B, Zhou X, You Z, Xu W, Fan J, Chen S, et al. Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage. Cell Death Dis. 2020;11:76.
Lu Y, Zhang XS, Zhang ZH, Zhou XM, Gao YY, Liu GJ, et al. Peroxiredoxin 2 activates microglia by interacting with toll-like receptor 4 after subarachnoid hemorrhage. J Neuroinflammation. 2018;15:87.
Zhang XS, Wu Q, Wu LY, Ye ZN, Jiang TW, Li W, et al. Sirtuin 1 activation protects against early brain injury after experimental subarachnoid hemorrhage in rats. Cell Death Dis. 2016;7:e2416.
Lind D, Franken S, Kappler J, Jankowski J, Schilling K. Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization. J Neurosci Res. 2005;79:295–302.
Negoescu A, Lorimier P, Labat-Moleur F, et al. In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations. J Histochem Cytochem. 1996;44(9):959–68.
Veldeman M, Coburn M, Rossaint R, Clusmann H, Nolte K, Kremer B, et al. Xenon reduces neuronal hippocampal damage and alters the pattern of microglial activation after experimental subarachnoid hemorrhage: a randomized controlled animal trial. Front Neurol. 2017;8:511.
Makino K, Osuka K, Watanabe Y, Usuda N, Hara M, Aoyama M, et al. Increased ICP promotes CaMKII-mediated phosphorylation of neuronal NOS at Ser847 in the hippocampus immediately after subarachnoid hemorrhage. Brain Res. 2015;1616:19–25.
Sabri M, Ai J, Lakovic K, D’abbondanza J, Ilodigwe D, Macdonald RL. Mechanisms of microthrombi formation after experimental subarachnoid hemorrhage. Neuroscience. 2012;224:26–37.
Tariq A, Ai J, Chen G, Sabri M, Jeon H, Shang X, et al. Loss of long-term potentiation in the hippocampus after experimental subarachnoid hemorrhage in rats. Neuroscience. 2010;165:418–26.
Wada K, Osuka K, Watanabe Y, Usuda N, Fukasawa M, Araki Y, et al. Subarachnoid hemorrhage induces neuronal nitric oxide synthase phosphorylation at Ser1412 in the dentate gyrus of the rat brain. Nitric Oxide. 2018;81:67–74.
Yin B, Xu Y, Wei RL, He F, Luo B, Wang J. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain Res. 2015;1609:63–71.
Ming GL, Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron. 2011;70:687–702.
Kase Y, Shimazaki T, Okano H. Current understanding of adult neurogenesis in the mammalian brain: how does adult neurogenesis decrease with age? Inflamm Regen. 2020;18(40):10.
van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. Functional neurogenesis in the adult hippocampus. Nature. 2002;415:1030–4.
Lim DA, Alvarez-Buylla A. The adult ventricular–subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis. Cold Spring Harb Perspect Biol. 2016;8:a018820.
Kohman RA, Rhodes JS. Neurogenesis, inflammation and behavior. Brain Behav Immun. 2013;27:22–32.
Kase Y, Otsu K, Shimazaki T, Okano H. Involvement of p38 in age-related decline in adult neurogenesis via modulation of Wnt signaling. Stem Cell Rep. 2019;12:1313–28.
Pedard M, El Amki M, Lefevre-Scelles A, Compère V, Castel H. Double direct injection of blood into the cisterna magna as a model of subarachnoid hemorrhage. J Vis Exp. 2020. https://doi.org/10.3791/61322.
Kamii H, Tominaga T. Filament perforation subarachnoid hemorrhage: mouse model. In: Chen J, Xu ZC, Xu XM, Zhang JH, editors. Animal models of acute neurological injuries. Springer protocols handbooks. Totowa: Humana Press; 2009. p. 279–86.
Muroi C, Fujioka M, Okuchi K, Fandino J, Keller E, Sakamoto Y, et al. Filament perforation model for mouse subarachnoid hemorrhage: surgical-technical considerations. Br J Neurosurg. 2014;28:722–32.
Prunell GF, Mathiesen T, Diemer NH, Svendgaard NA. Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery. 2003;52:165–76 discussion 75–6.
Lee JY, Sagher O, Keep R, Hua Y, Xi G. Comparison of experimental rat models of early brain injury after subarachnoid hemorrhage. Neurosurgery. 2009;65:331–43 discussion 43.
Zoerle T, Lombardo A, Colombo A, Longhi L, Zanier ER, Rampini P, et al. Intracranial pressure after subarachnoid hemorrhage. Crit Care Med. 2015;43:168–76.
Hanafy KA. The role of microglia and the TLR4 pathway in neuronal apoptosis and vasospasm after subarachnoid hemorrhage. J Neuroinflammation. 2013;10:83.
Zhen X, et al. Resident Microglia Activate before Peripheral Monocyte Infiltration and p75NTR Blockade Reduces Microglial Activation and Early Brain Injury after Subarachnoid Hemorrhage. ACS Chem Nerosci. 2019;10(1):412–23.
Provencio JJ, Altay T, Smithason S, Moore SK, Ransohoff RM. Depletion of Ly6G/C+ cells ameliorates delayed cerebral vasospasm in subarachnoid hemorrhage. J Neurochem. 2011;232:94–100.
Duris K, Lipkova J, Splichal Z, Madaraszova T, Jurajda M. Early inflammatory response in the brain and anesthesia recovery time evaluation after experimental subarachnoid hemorrhage. Transl Stroke Res. 2018;10:308–18.
Blackburn SL, Kumar PT, McBride D, Zeineddine HA, Leclerc J, Choi HA, et al. Unique contribution of haptoglobin and haptoglobin genotype in aneurysmal subarachnoid hemorrhage. Front Physiol. 2018;9:592.
Offner H, Hurn PD. A novel hypothesis: regulatory B lymphocytes shape outcome from experimental stroke. Transl Stroke Res. 2012;3:324–30.
Hasegawa Y, Suzuki H, Uekawa K, Kawano T, Kim-Mitsuyama S. Characteristics of cerebrovascular injury in the hyperacute phase after induced severe subarachnoid hemorrhage. Transl Stroke Res. 2015;6:458–66.
Liesz A, Kleinschnitz C. Regulatory T cells in post-stroke immune homeostasis. Transl Stroke Res. 2016;7:313–21.
Bartsch T, Wulff P. The hippocampus in aging and disease: from plasticity to vulnerability. Neuroscience. 2015;309:1–16.
Li N, Chen TW, Guo ZV, Gerfen CR, Svoboda K. A motor cortex circuit for motor planning and movement. Nature. 2015;519:51–6.
Ghazizadeh A, Hong S, Hikosaka O. Prefrontal cortex represents long-term memory of object values for months. Curr Biol. 2018;28:2206–17.e5.
Florez WA, García-Ballestas E, Deora H, Agrawal A, Martinez-Perez R, Galwankar S, et al. Intracranial hypertension in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurosurg Rev. 2021;44:203–11.
Lee GY, Ryu CW, Ko HC, Jahng GH. Correlation between gray matter volume loss followed by aneurysmal subarachnoid hemorrhage and subarachnoid hemorrhage volume. Neuroradiology. 2020;62:1401–9.
Tosun C, Kurland DB, Mehta R, Castellani RJ, deJong JL, Kwon MS, et al. Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage. Stroke. 2013;44:3522–8.
Pradilla G, Thai QA, Legnani FG, Hsu W, Kretzer RM, Wang PP, et al. Delayed intracranial delivery of a nitric oxide donor from a controlled-release polymer prevents experimental cerebral vasospasm in rabbits. Neurosurgery. 2004;55:1393–400 discussion 9–400.
Sabri M, Jeon H, Ai J, Tariq A, Shang X, Chen G, et al. Anterior circulation mouse model of subarachnoid hemorrhage. Brain Res. 2009;1295:179–85.
Garcia JH, Wagner S, Liu K-F, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Stroke. 1995;26:627–35.
Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167:327–34.