Studies on the selective toxicity of guanazole in mice

European Journal of Cancer (1965) - Tập 14 - Trang 33-40 - 1978
C. Dave1, M.A. Paul1, Y.M. Rustum1
1Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Memorial Institute, New York State Department of Health, 666 Elm Street, Buffalo, NY 14263, U.S.A.

Tài liệu tham khảo

Livingston, 1969, 1 Hewlett, 1973, Intermittent guanazole therapy in adult acute leukemia, Clin. Pharmacol. Therap., 14, 271, 10.1002/cpt1973142271 Yakar, 1973, Clinical pharmacological trial of guanazole, Cancer Res., 32, 972 Hahn, 1970, Certain aspects of pharmacology of guanazole—a new antitumor agent, Pharmacologist, 12, 44 Hahn, 1972, Pharmacology of 3,5-diamino-1,2,4-triazole (guanazole). I. Antitumor activity of guanazole, J. nat. Cancer Inst., 48, 783 Dave, 1975, Pharmacokinetics of guanazole in patients with acute myelocytic leukemia, Clin. Pharmacol. Therap., 17, 36, 10.1002/cpt197517136 Brockman, 1970, Inhibition of ribonucleotide reductase, DNA synthesis and L1210 leukemia by guanazole, Cancer Res., 30, 2358 Wheeler, 1972, Comparison of the effects of several inhibitors of the synthesis of nucleic acids upon the viability and progression through the cell cycle of cultured H. Ep. No. 2 cells, Cancer Res., 32, 2661 Paul, 1975, A simple method for long-term drug infusion in mice: evaluation of guanazole as a model, 148, 118 Dave, 1972, Uptake and intracellular distribution of 4,4′-diacetyldiphenylurea-bis(guanylhydrazone) in sensitive and resistant leukemia L1210 cells, Biochem. Pharmacol., 21, 2681, 10.1016/0006-2952(72)90017-2 Schneider, 1957, Determination of nucleic acids in tissues by pentose analysis, Meth. Enzymol., 3, 680, 10.1016/S0076-6879(57)03442-4 Burton, 1956, A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid, J. Biochem., 63, 315, 10.1042/bj0620315 Dave, 1974, Colorimetric determination of guanazole in plasma and blood, J. pharm. Sci., 63, 347, 10.1002/jps.2600630307 Rustum, 1973, Methods for the separation and identification of ribonucleotides on DEAE-cellulose, Anal. Biochem., 53, 411, 10.1016/0003-2697(73)90088-2 Rustum, 1974, Metabolism of N6 (Δ2-isopentenyl) adenosine in rat liver, Biochem. Pharmacol., 23, 2469, 10.1016/0006-2952(74)90244-5 Weber, 1971, Metabolism of hepatomas of different growth rates in situ and during ischemia, Cancer Res., 31, 2177 Dave, 1973, Mechanism of the inhibition of DNA biosynthesis by 4,4′-diacetyldiphenylurea-bis(guanylhydrazone) in leukemia L1210 cells, Cancer Res., 33, 2129 Fuji, 1975, Selection for high immunogenicity in drug resistant sublines of murine lymphomas demonstrated by plaque and assay, Cancer Res., 35, 946 Hakala, 1975, Uptake and distribution of 4,4′-diacetyldiphenylurea-bis(guanylhydrazone) in sensitive and resistant sarcoma 180 cells in vitro, Biochem. Pharmacol., 20, 81, 10.1016/0006-2952(71)90474-6 Lewis, 1974, Altered ribonucleotide reductase activity in mammalian tissue culture cells resistant to hydroxyurea', Biochem. biophys. Res. Commun., 60, 926, 10.1016/0006-291X(74)90403-3