Structure–cytotoxicity relationship of drug-initiated polymer prodrug nanoparticles

Polymer Chemistry - Tập 8 Số 34 - Trang 5174-5184
Yinyin Bao1,2,3,4,5, Julien Nicolas1,2,3,4,5
192290 Châtenay-Malabry
2CNRS UMR 8612
3Faculté de Pharmacie
4Institut Galien Paris-Sud
5Univ Paris-Sud

Tóm tắt

Cladribine (CdA)-based polymer prodrug nanoparticles were obtained by “drug-initiated” RAFT polymerization of squalenyl methacrylate (SqMA) from two different CdA-bearing chain transfer agents (CTAs) to evaluate the influence of the nature of the linkage between CdA and the CTA, and the bulkiness of the polymer, on the drug release and the biological performance.

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