Structure-Chemical Analysis of Multiple Complexations by Cyclodextrins
Tóm tắt
The interactions between cyclodextrin and substrates having two binding sites in aqueous solution are reviewed. For such substrates, multiple equilibria, NMR chemical shift variations with full binding, solution structures of complexes, and the effect of cavity size are analyzed quantitatively. After general treatments of multiple equilibria and chemical shifts are given, they are applied to three bivalent substrates of diheptanoyllecithin, dialkyldimethylammonium bromide, and oxyphenium bromide for demonstrating their usefulness. The solution structures of complexes play a crucial role in these basic researches as well as the applications of cyclodextrins, such as bitter taste reduction and stabilization of labile substrates.
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