Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells

Akune, 2004, PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors, J. Clin. Invest., 113, 846, 10.1172/JCI200419900

Ali, 2011, Novel brominated flame retardants in Belgian and UK indoor dust: implications for human exposure, Chemosphere, 83, 1360, 10.1016/j.chemosphere.2011.02.078

Antizar-Ladislao, 2008, Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review, Environ. Int., 34, 292, 10.1016/j.envint.2007.09.005

Aubert, 2010, Rosiglitazone and pioglitazone increase fracture risk in women and men with type 2 diabetes, Diabetes Obesity Metab., 12, 716, 10.1111/j.1463-1326.2010.01225.x

Beier, 2013, Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling, Environ. Health Perspect., 121, 97, 10.1289/ehp.1205374

Bennett, 2005, Regulation of osteoblastogenesis and bone mass by Wnt10b, Proc. Natl. Acad Sci. U. S. A., 102, 3324, 10.1073/pnas.0408742102

Bilik, 2010, Thiazolidinediones and fractures: evidence from translating research into action for diabetes, J. Clin. Endocrinol. Metab., 95, 4560, 10.1210/jc.2009-2638

Bility, 2004, Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters, Toxicol. Sci., 82, 170, 10.1093/toxsci/kfh253

Bonewald, 2011, The amazing osteocyte, J. Bone Miner Res., 26, 229, 10.1002/jbmr.320

Carfi, 2008, TBTC induces adipocyte differentiation in human bone marrow long term culture, Toxicology, 249, 11, 10.1016/j.tox.2008.03.025

Cariou, 2008, Exposure assessment of French women and their newborns to tetrabromobisphenol-A: occurrence measurements in maternal adipose tissue, serum, breast milk and cord serum, Chemosphere, 73, 1036, 10.1016/j.chemosphere.2008.07.084

Choi, 2014, A novel non-agonist peroxisome proliferator-activated receptor gamma (PPARgamma) ligand UHC1 blocks PPARgamma phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity, J. Biol. Chem., 289, 26618, 10.1074/jbc.M114.566794

D'Hollander, 2010, Brominated flame retardants and perfluorinated compounds in indoor dust from homes and offices in Flanders, Belgium, Chemosphere, 81, 478, 10.1016/j.chemosphere.2010.07.043

de Wit, 2010, Brominated flame retardants in the Arctic environment–trends and new candidates, Sci. Total Environ., 408, 2885, 10.1016/j.scitotenv.2009.08.037

Ducy, 1997, Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation, Cell, 89, 747, 10.1016/S0092-8674(00)80257-3

Feige, 2007, The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis, J. Biol. Chem., 282, 19152, 10.1074/jbc.M702724200

Greenberg, 1991, Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets, J. Biol. Chem., 266, 11341, 10.1016/S0021-9258(18)99168-4

Grun, 2006, Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling, Endocrinology, 147, S50, 10.1210/en.2005-1129

Grun, 2006, Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates, Mol. Endocrinol., 20, 2141, 10.1210/me.2005-0367

He, 2013, Concentrations and trends of halogenated flame retardants in the pooled serum of residents of Laizhou Bay China, Environ. Toxicol. Chem., 32, 1242, 10.1002/etc.2172

Hurst, 2003, Activation of PPARa and PPARg by environmental phthalate monoesters, Toxicol. Appl. Pharmacol.

Iqbal, 2013, Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes, Proc. Natl. Acad Sci. U. S. A., 110, 11115, 10.1073/pnas.1220919110

Jeon, 2003, Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts, J. Biol. Chem., 278, 23270, 10.1074/jbc.M211610200

Kanayama, 2005, Organotin compounds promote adipocyte differentiation as agonists of the peroxisome proliferator-activated receptor gamma/retinoid X receptor pathway, Mol. Pharmacol., 67, 766, 10.1124/mol.104.008409

Kang, 2007, Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma, J. Biol. Chem., 282, 14515, 10.1074/jbc.M700030200

Kannan, 2010, Organotin compounds, including butyltins and octyltins, in house dust from Albany, New York, USA, Arch. Environ. Contam Toxicol., 58, 901, 10.1007/s00244-010-9513-6

Kim, 1998, ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand, Proc. Natl. Acad. Sci. U. S. A., 95, 4333, 10.1073/pnas.95.8.4333

Kirchner, 2010, Prenatal exposure to the environmental obesogen tributyltin predisposes multipotent stem cells to become adipocytes, Mol. Endocrinol., 24, 526, 10.1210/me.2009-0261

Koch, 2003, An estimation of the daily intake of di(2-ethylhexyl) phthalate (DEHP) and other phthalates in the general population, Int. J. Hyg. Environ. Health, 206, 77, 10.1078/1438-4639-00205

Kolli, 2014, Partial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone mass, PLoS One, 9, e96323, 10.1371/journal.pone.0096323

Korkalainen, 2009, Dioxins interfere with differentiation of osteoblasts and osteoclasts, Bone, 44, 1134, 10.1016/j.bone.2009.02.019

Koskela, 2012, Synergistic effects of tributyltin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on differentiating osteoblasts and osteoclasts, Toxicol. Appl. Pharmacol., 263, 210, 10.1016/j.taap.2012.06.011

Lazarenko, 2006, Netoglitazone is a PPAR-gamma ligands with selective effects on bone and fat, Bone, 38, 74, 10.1016/j.bone.2005.07.008

Lazarenko, 2007, Rosiglitazone induces decreases in bone mass and strength that are reminiscent of aged bone, Endocrinology, 148, 2669, 10.1210/en.2006-1587

Lecka-Czernik, 1999, Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2, J. Cell. Biochem., 74, 357, 10.1002/(SICI)1097-4644(19990901)74:3<357::AID-JCB5>3.0.CO;2-7

Lecka-Czernik, 2002, Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation, Endocrinology, 143, 2376, 10.1210/endo.143.6.8834

Li, 2013, Exposure levels of environmental endocrine disruptors in mother-newborn pairs in China and their placental transfer characteristics, PLoS One, 8, e62526, 10.1371/journal.pone.0062526

Moerman, 2004, Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways, Aging Cell., 3, 379, 10.1111/j.1474-9728.2004.00127.x

Moldes, 2003, Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis, Biochem. J., 376, 607, 10.1042/bj20030426

Pfaffl, 2001, A new mathematical model for relative quantification in real-time RT-PCR, Nucleic Acids Res., 29, e45, 10.1093/nar/29.9.e45

Rahman, 2012, Beta-catenin directly sequesters adipocytic and insulin sensitizing activities but not osteoblastic activity of PPARgamma2 in marrow mesenchymal stem cells, PLoS One, 7, e51746, 10.1371/journal.pone.0051746

Riu, 2011, Peroxisome proliferator-activated receptor gamma is a target for halogenated analogs of bisphenol A, Environ. Health Perspect., 119, 1227, 10.1289/ehp.1003328

Rosen, 2006, Mechanisms of disease: is osteoporosis the obesity of bone?, Nat. Clin. Pract. Rheumatol., 2, 35, 10.1038/ncprheum0070

Rzonca, 2004, Bone is a target for the antidiabetic compound rosiglitazone, Endocrinology, 145, 401, 10.1210/en.2003-0746

Schwartz, 2006, Thiazolidinedione use and bone loss in older diabetic adults, J. Clin. Endocrinol. Metab., 91, 3349, 10.1210/jc.2005-2226

Springer, 2012, Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust, Environ. Health Perspect., 120, 1711, 10.1289/ehp.1204932

Tickner, 2001, Health risks posed by use of di-2-ethylhexyl phthalate (DEHP) in PVC medical devices: a critical review, Am. J. Ind. Med., 39, 100, 10.1002/1097-0274(200101)39:1<100::AID-AJIM10>3.0.CO;2-Q

Tontonoz, 1994, mPPARg2: tissue-specific regulator of an adipocyte enhancer, Genes Dev., 8, 1224, 10.1101/gad.8.10.1224

Tsukamoto, 2004, Inhibition of ossification in vivo and differentiation of osteoblasts in vitro by tributyltin, Biochem. Pharmacol., 68, 739, 10.1016/j.bcp.2004.04.020

USDHHS, 2004

Wu, 2014, Effects of arsenic on osteoblast differentiation and on bone mineral density and microstructure in rats, Environ. Health Perspect., 122, 10.1289/ehp.1307832

Yanik, 2011, Organotins are potent activators of PPAR{gamma} and adipocyte differentiation in bone marrow multipotent mesenchymal stromal cells, Toxicol. Sci., 122, 476, 10.1093/toxsci/kfr140