Tổ chức cấu trúc và tương tác của các miền xuyên màng trong protein tetraspanin
Tóm tắt
Các protein thuộc họ tetraspanin chứa bốn miền xuyên màng (TM1-4) được liên kết bởi hai vòng ngoài tế bào và một vòng ngắn trong tế bào, với các đầu N- và C-terminus ngắn ở trong tế bào. Mặc dù đã có phân tích cấu trúc và chức năng của vòng ngoài lớn hơn, tổ chức và vai trò của các miền xuyên màng vẫn chưa được đánh giá một cách hệ thống.
Trong số 28 protein tetraspanin ở người, các chuỗi TM1-3 hiển thị một mô hình lặp heptad đặc trưng (
Các kết quả của chúng tôi gợi ý rằng các tương tác nội và liên phân tử của tetraspanin được trung gian bởi các dư lượng được bảo tồn ở các vùng gần nhau nhưng khác biệt của TM1 và TM2. Một yếu tố cấu trúc chính xác định tương tác TM1-TM2 trong các tetraspanin là sự đóng gói cụ thể của các dư lượng lớn chống lại các dư lượng nhỏ.
Từ khóa
Tài liệu tham khảo
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