Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like

Toxicon - Tập 72 - Trang 52-63 - 2013
Guilherme H.M. Salvador1, Walter L.G. Cavalcante1,2, Juliana I. dos Santos1, Márcia Gallacci2, Andreimar M. Soares3, Marcos R.M. Fontes1
1Depto. de Física e Biofísica, Instituto de Biociências, UNESP – Univ Estadual Paulista, Botucatu, SP, Brazil
2Depto. de Farmacologia, Instituto de Biociências, UNESP – Univ Estadual Paulista, Botucatu, SP, Brazil
3Centro de Estudos de Biomoléculas Aplicadas à Saúde (CEBio), Fundação Oswaldo Cruz, FIOCRUZ Rondônia e Departamento de Medicina, Universidade Federal de Rondônia, UNIR, Porto Velho, RO, Brazil

Tài liệu tham khảo

Andriao-Escarso, 2000, Myotoxic phospholipases A2 in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu, Biochimie, 82, 755, 10.1016/S0300-9084(00)01150-0 Aragao, 2009, Shared structural determinants for the calcium-independent liposome membrane permeabilization and sarcolemma depolarization in Bothropstoxin-I, a LYS49-PLA2 from the venom of Bothrops jararacussu, Int. J. Biochem. Cell Biol., 41, 2588, 10.1016/j.biocel.2009.08.016 Arni, 1999, Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani, Arch. Biochem. Biophys., 366, 177, 10.1006/abbi.1999.1210 Arni, 1996, Phospholipase A2-a structural review, Toxicon, 34, 827, 10.1016/0041-0101(96)00036-0 Arni, 1995, Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom, Acta Crystallogr. D Biol. Crystallogr., 51, 311, 10.1107/S0907444994011455 Borges, 1998, Seleção de habitat em duas espécies de jararaca (Bothrops moojeni Hoge e B. neuwiedi Wagler) (Serpentes, Viperidae), Revista Brasileira de Biologia, 58, 591, 10.1590/S0034-71081998000400006 Brunger, 1998, Crystallography & NMR system: a new software suite for macromolecular structure determination, Acta Crystallogr. D Biol. Crystallogr., 54, 905, 10.1107/S0907444998003254 Cavalcante, 2007, Neutralization of snake venom phospholipase A2 toxins by aqueous extract of Casearia sylvestris (Flacourtiaceae) in mouse neuromuscular preparation, J. Ethnopharmacol., 112, 490, 10.1016/j.jep.2007.04.002 Chen, 2010, MolProbity: all-atom structure validation for macromolecular crystallography, Acta Crystallogr. D Biol. Crystallogr., 66, 12, 10.1107/S0907444909042073 Correia-de-Sa, 2013, Bothropstoxin-I reduces evoked acetylcholine release from rat motor nerve terminals: radiochemical and real-time video-microscopy studies, Toxicon, 61C, 16, 10.1016/j.toxicon.2012.10.014 da Silva Giotto, 1998, Crystallographic and spectroscopic characterization of a molecular hinge: conformational changes in bothropstoxin I, a dimeric Lys49-phospholipase A2 homologue, Proteins, 30, 442, 10.1002/(SICI)1097-0134(19980301)30:4<442::AID-PROT11>3.0.CO;2-I de Azevedo, 1997, Crystal Structure of Myotoxin-II: a myotoxic phospholipase A2-homologue from Bothrops moojeni Venom, Protein Pept. Lett., 4, 329, 10.2174/092986650405221017153439 DeLano, 2002 Delatorre, 2011, Crystal structure of Bn IV in complex with myristic acid: a Lys49 myotoxic phospholipase A2 from Bothrops neuwiedi venom, Biochimie, 93, 513, 10.1016/j.biochi.2010.11.003 Doley, 2009, Protein complexes in snake venom, Cell Mol. Life Sci., 66, 2851, 10.1007/s00018-009-0050-2 dos Santos, 2009, Comparative structural studies on Lys49-phospholipases A2 from Bothrops genus reveal their myotoxic site, J. Struct. Biol., 167, 106, 10.1016/j.jsb.2009.04.003 dos Santos, 2011, Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA2 inhibition, PLoS One, 6, e28521, 10.1371/journal.pone.0028521 dos Santos, 2011, Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A2 class, Proteins, 79, 61, 10.1002/prot.22858 Ducruix, 1992 Emsley, 2004, Coot: model-building tools for molecular graphics, Acta Crystallogr. D Biol. Crystallogr., 60, 2126, 10.1107/S0907444904019158 Fatt, 1951, An analysis of the end-plate potential recorded with an intracellular electrode, J. Physiol., 115, 320, 10.1113/jphysiol.1951.sp004675 Fernandes, 2010, Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca2+-binding loop region for the catalytically inactive Lys49-PLA2s, J. Struct. Biol., 171, 31, 10.1016/j.jsb.2010.03.019 Gallacci, 2010, Understanding the in vitro neuromuscular activity of snake venom Lys49 phospholipase A2 homologues, Toxicon, 55, 1, 10.1016/j.toxicon.2009.10.025 Gallacci, 2006, Paralyzing and myotoxic effects of a recombinant bothropstoxin-I (BthTX-I) on mouse neuromuscular preparations, Exp. Toxicol. Pathol., 57, 239, 10.1016/j.etp.2005.09.004 Gutierrez, 1980, Proteolytic, hemorrhagic and myonecrotic effects of the venoms of Costa Rican snakes from the genera Bothrops, Crotalus and Lachesis (author's transl), Toxicon, 18, 315, 10.1016/0041-0101(80)90011-2 Gutierrez, 1995, Phospholipase A2 myotoxins from Bothrops snake venoms, Toxicon, 33, 1405, 10.1016/0041-0101(95)00085-Z Gutierrez, 2003, Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity, Toxicon, 42, 915, 10.1016/j.toxicon.2003.11.005 Gutierrez, 2006, Confronting the neglected problem of snake bite envenoming: the need for a global partnership, Plos Med., 3, e150, 10.1371/journal.pmed.0030150 Harrison, 2009, Snake envenoming: a disease of poverty, PLoS Negl Trop. Dis., 3, e569, 10.1371/journal.pntd.0000569 Homsi-Brandeburgo, 1988, Fractionation of Bothrops jararacussu snake venom: partial chemical characterization and biological activity of bothropstoxin, Toxicon, 26, 615, 10.1016/0041-0101(88)90244-9 Kasturiratne, 2008, The global burden of snakebite: a literature analysis and modelling based on regional estimates of envenoming and deaths, Plos Med., 5, 1591, 10.1371/journal.pmed.0050218 Kini, 1997 Kini, 2003, Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes, Toxicon, 42, 827, 10.1016/j.toxicon.2003.11.002 Krissinel, 2007, Inference of macromolecular assemblies from crystalline state, J. Mol. Biol., 372, 774, 10.1016/j.jmb.2007.05.022 Lee, 2001, Structural basis for low catalytic activity in Lys49 phospholipases A2-a hypothesis: the crystal structure of piratoxin II complexed to fatty acid, Biochemistry-Us, 40, 28, 10.1021/bi0010470 Lomonte, 2003, An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action, Toxicon, 42, 885, 10.1016/j.toxicon.2003.11.008 Lomonte, 1990, Isolation of basic myotoxins from Bothrops moojeni and Bothrops atrox snake venoms, Toxicon, 28, 1137, 10.1016/0041-0101(90)90114-M Lomonte, 2012, Snake venom Lys49 myotoxins: from phospholipases A2 to non-enzymatic membrane disruptors, Toxicon, 60, 520, 10.1016/j.toxicon.2012.02.007 Magro, 2003, Crystal structures of BnSP-7 and BnSP-6, two Lys49-phospholipases A2: quaternary structure and inhibition mechanism insights, Biochem. Biophys. Res. Commun., 311, 713, 10.1016/j.bbrc.2003.10.047 Marchi-Salvador, 2009, Crystal structure of a phospholipase A2 homolog complexed with p-bromophenacyl bromide reveals important structural changes associated with the inhibition of myotoxic activity, Biochim. Biophys. Acta, 1794, 1583, 10.1016/j.bbapap.2009.07.005 Mebs, 1983, Local necrotizing effect of snake venoms on skin and muscle: relationship to serum creatine kinase, Toxicon, 21, 393, 10.1016/0041-0101(83)90096-X Melgarejo, 2003, 33 Montecucco, 2008, Cellular pathology induced by snake venom phospholipase A2 myotoxins and neurotoxins: common aspects of their mechanisms of action, Cell Mol. Life Sci., 65, 2897, 10.1007/s00018-008-8113-3 Murakami, 2005, Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin, J. Mol. Biol., 350, 416, 10.1016/j.jmb.2005.04.072 Murakami, 2007, Interfacial surface charge and free accessibility to the PLA2-active site-like region are essential requirements for the activity of Lys49 PLA2 homologues, Toxicon, 49, 378, 10.1016/j.toxicon.2006.10.011 Otwinowski, 1997, Processing of X-ray diffraction data collected in oscillation mode, Macromol. Crystallogr. Pt A, 276, 307, 10.1016/S0076-6879(97)76066-X Potterton, 2004, Developments in the CCP4 molecular-graphics project, Acta Crystallogr. D Biol. Crystallogr., 60, 2288, 10.1107/S0907444904023716 Queiroz, 1984, Histopathological changes caused by venom of urutu snake (Bothrops alternatus) in mouse skeletal muscle, Rev. Inst. Med. Trop. Sao Paulo, 26, 247, 10.1590/S0036-46651984000500004 Randazzo-Moura, 2008, Structural characterization and neuromuscular activity of a new Lys49 phospholipase A2 homologous (Bp-12) isolated from Bothrops pauloensis snake venom, Protein J., 27, 355, 10.1007/s10930-008-9144-1 Rodrigues-Simioni, 1995, No role for enzymatic activity or dantrolene-sensitive Ca2+ stores in the muscular effects of bothropstoxin, a Lys49 phospholipase A2 myotoxin, Toxicon, 33, 1479, 10.1016/0041-0101(95)00089-5 Rosenfeld, 1971, Measurement of the coagulation activity of snake venoms: importance to scientific research and therapeutic application, Rev. Paul Med., 77, 149 Russell, 1991, Venomous arthropods, Vet. Hum. Toxicol., 33, 505 Salvador, 2013, Structural and phylogenetic studies with MjTX-i reveal a multi-oligomeric toxin – a novel feature in Lys49-PLA2s protein class, PLoS One, 8, e60610, 10.1371/journal.pone.0060610 Saúde, 2001 Soares, 2000, Structural and functional characterization of myotoxin I, a Lys49 phospholipase A2 homologue from Bothrops moojeni (Caissaca) snake venom, Arch. Biochem. Biophys., 373, 7, 10.1006/abbi.1999.1492 Soares, 2001, Dissociation of enzymatic and pharmacological properties of piratoxins-I and -III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom, Arch. Biochem. Biophys., 387, 188, 10.1006/abbi.2000.2244 Stabeli, 2006, Bothrops moojeni myotoxin-II, a Lys49-phospholipase A2 homologue: an example of function versatility of snake venom proteins, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 142, 371, 10.1016/j.cbpc.2005.11.020 Vagin, 1997, MOLREP: an automated program for molecular replacement, J. Appl. Crystallogr., 30, 1022, 10.1107/S0021889897006766 Wallace, 1995, LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions, Protein Eng., 8, 127, 10.1093/protein/8.2.127 Ward, 2002, Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis, Biochem. J., 362, 89, 10.1042/0264-6021:3620089 Watanabe, 2005, Structural insights for fatty acid binding in a Lys49-phospholipase A2: crystal structure of myotoxin II from Bothrops moojeni complexed with stearic acid, Biochimie, 87, 161, 10.1016/j.biochi.2004.11.005 Williams, 2010, The Global Snake Bite Initiative: an antidote for snake bite, Lancet, 375, 89, 10.1016/S0140-6736(09)61159-4