Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Arkin, 2004, Small-molecule inhibitors of protein-protein interactions: progressing towards the dream, Nat. Rev. Drug Discov., 3, 301, 10.1038/nrd1343

Barre, 2006, Folding of the repeat domain of tau upon binding to lipid surfaces, J. Mol. Biol., 362, 312, 10.1016/j.jmb.2006.07.018

Berg, 2002, Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts, Proc. Natl. Acad. Sci. USA, 99, 3830, 10.1073/pnas.062036999

Berjanskii, 2006, PREDITOR: a web server for predicting protein torsion angle restraints, Nucleic Acids Res., 34, W63, 10.1093/nar/gkl341

Blackwood, 1991, Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc, Science, 251, 1211, 10.1126/science.2006410

Cheng, 2006, Rational drug design via intrinsically disordered protein, Trends Biotechnol., 24, 435, 10.1016/j.tibtech.2006.07.005

Dang, 1999, c-Myc target genes involved in cell growth, apoptosis, and metabolism, Mol. Cell. Biol., 19, 1, 10.1128/MCB.19.1.1

Dyson, 2002, Coupling of folding and binding for unstructured proteins, Curr. Opin. Struct. Biol., 12, 54, 10.1016/S0959-440X(02)00289-0

Dyson, 2005, Intrinsically unstructured proteins and their functions, Nat. Rev. Mol. Cell Biol., 6, 197, 10.1038/nrm1589

Gunasekaran, 2003, Extended disordered proteins: targeting function with less scaffold, Trends Biochem. Sci., 28, 81, 10.1016/S0968-0004(03)00003-3

Iakoucheva, 2002, Intrinsic disorder in cell-signaling and cancer-associated proteins, J. Mol. Biol., 323, 573, 10.1016/S0022-2836(02)00969-5

Kiessling, 2006, Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules, Chem. Biol., 13, 745, 10.1016/j.chembiol.2006.05.011

Kodadek, 2002, Inhibition of proteolysis and other posttranslational modifications with substrate-targeted inhibitors, Biopolymers, 66, 134, 10.1002/bip.10233

Kukar, 2008, Substrate-targeting gamma-secretase modulators, Nature, 453, 925, 10.1038/nature07055

Lee, 1998, Absorption and fluorescence of tyrosine hydrogen-bonded to amide-like ligands, J. Phys. Chem. B, 102, 4612, 10.1021/jp9719927

MacKerell, 1998, All-atom empirical potential for molecular modeling and dynamic studies of proteins, J. Phys. Chem. B, 102, 3586, 10.1021/jp973084f

Morohashi, 2005, Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP, Biochem. Pharmacol., 70, 37, 10.1016/j.bcp.2005.03.035

Morris, 1998, Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function, J. Comput. Chem., 19, 1639, 10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B

Nair, 2003, X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors, Cell, 112, 193, 10.1016/S0092-8674(02)01284-9

Obradovic, 2005, Exploiting heterogeneous sequence properties improves prediction of protein disorder, Proteins, 61, 176, 10.1002/prot.20735

Oldfield, 2005, Comparing and combining predictors of mostly disordered proteins, Biochemistry, 44, 1989, 10.1021/bi047993o

Ponzielli, 2005, Cancer therapeutics: targeting the dark side of Myc, Eur. J. Cancer, 41, 2485, 10.1016/j.ejca.2005.08.017

Rodi, 1999, Screening of a library of phage-displayed peptides identifies human bcl-2 as a taxol-binding protein, J. Mol. Biol., 285, 197, 10.1006/jmbi.1998.2303

Rose, 2006, A backbone-based theory of protein folding, Proc. Natl. Acad. Sci. USA, 103, 16623, 10.1073/pnas.0606843103

Tompa, 2002, Intrinsically unstructured proteins, Trends Biochem. Sci., 27, 527, 10.1016/S0968-0004(02)02169-2

Tompa, 2005, Structural disorder throws new light on moonlighting, Trends Biochem. Sci., 30, 484, 10.1016/j.tibs.2005.07.008

Uversky, 2002, Natively unfolded proteins: a point where biology waits for physics, Protein Sci., 11, 739, 10.1110/ps.4210102

Uversky, 2005, Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling, J. Mol. Recognit., 18, 343, 10.1002/jmr.747

Uversky, 2008, Intrinsically disordered proteins in human diseases: introducing the D2 concept, Annu. Rev. Biophys., 37, 215, 10.1146/annurev.biophys.37.032807.125924

Wang, 2007, Improved low molecular weight Myc-Max inhibitors, Mol. Cancer Ther., 6, 2399, 10.1158/1535-7163.MCT-07-0005

Wishart, 1992, The chemical shift index: a fast and simple method for the assignment of protein secondary structure through NMR spectroscopy, Biochemistry, 31, 1647, 10.1021/bi00121a010

Wright, 1999, Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm, J. Mol. Biol., 293, 321, 10.1006/jmbi.1999.3110

Xu, 2006, A credit-card library approach for disrupting protein-protein interactions, Bioorg. Med. Chem., 14, 2660, 10.1016/j.bmc.2005.11.052

Yin, 2003, Low molecular weight inhibitors of Myc-Max interaction and function, Oncogene, 22, 6151, 10.1038/sj.onc.1206641