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Microspheres hydroxyapatit mesopor và phát quang được thay thế bởi strontium cho việc phóng thích thuốc bền vững
Tóm tắt
Microsphere hydroxyapatit (Sr)-thay thế đa chức năng đã được chuẩn bị qua phương pháp thủy nhiệt, trong đó các chức năng phát quang và phóng thích thuốc kiểm soát có thể được thực hiện. Cấu trúc và hình thái của các microsphere được chuẩn bị đã được nghiên cứu bằng các phương pháp XRD, FTIR, SEM, TEM, HR-TEM, và BET. Các tính chất quang học được điều tra bằng các phép đo phát quang (PL) và XPS. Tiếp theo, các microsphere đa chức năng đã được sử dụng làm mang thuốc nghiên cứu với vancomycin làm thuốc mẫu. Kết quả thực nghiệm cho thấy rằng thành phần, hình thái, tính chất phát quang và hành vi lưu trữ/phóng thích thuốc bị ảnh hưởng rõ rệt bởi lượng Sr. Các microsphere với Sr2+/(Ca2++Sr2+) = 0.3 cho sự thay thế Sr cho thấy diện tích bề mặt riêng lớn nhất, cấu trúc mao quản tốt nhất và cường độ PL mạnh nhất. Tất cả các mẫu đều thể hiện động học phóng thích thuốc bền vững đáng kể. Ngoài ra, cường độ PL của SrHA trong hệ thống phóng thích thuốc tăng lên theo thời gian phóng thích tích lũy (lượng) của vancomycin, điều này có thể giúp theo dõi khả năng phóng thích thuốc qua sự thay đổi cường độ phát quang. Nghiên cứu của chúng tôi cho thấy triển vọng tiềm năng rằng các microsphere mesopor SrHA đa chức năng được chế tạo có thể được ứng dụng trong lĩnh vực tái tạo xương và phóng thích thuốc.
Từ khóa
#strontium #hydroxyapatite #microsphere #phát quang #phóng thích thuốc #tái tạo xươngTài liệu tham khảo
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