Striking crosstalk of ROCK signaling with endothelial function

Van Aelst, 1997, Rho GTPases and signaling networks, Genes Dev, 11, 2295, 10.1101/gad.11.18.2295

Takai, 1995, Rho as a regulator of the cytoskeleton, Trends Biochem Sci, 20, 227, 10.1016/S0968-0004(00)89022-2

Amano, 1996, Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase), J Biol Chem, 271, 20246, 10.1074/jbc.271.34.20246

Shimokawa, 2005, Rho-kinase is an important therapeutic target in cardiovascular medicine, Arterioscler Thromb Vasc Biol, 25, 1767, 10.1161/01.ATV.0000176193.83629.c8

Masumoto, 2001, Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans, Hypertension, 38, 1307, 10.1161/hy1201.096541

Fukumoto, 2005, Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension, Heart, 91, 391, 10.1136/hrt.2003.029470

Riento, 2003, RhoE binds to ROCK I and inhibits downstream signaling, Mol Cell Biol, 23, 4219, 10.1128/MCB.23.12.4219-4229.2003

Nakagawa, 1996, ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice, FEBS Lett, 392, 189, 10.1016/0014-5793(96)00811-3

Di Cunto, 2000, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis, Neuron, 28, 115, 10.1016/S0896-6273(00)00090-8

Blum, 2001, An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression, J Biol Chem, 276, 33428, 10.1074/jbc.M105474200

Chevrier, 2002, The Rho-associated protein kinase p160ROCK is required for centrosome positioning, J Cell Biol, 157, 807, 10.1083/jcb.200203034

Thumkeo, 2003, Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death, Mol Cell Biol, 23, 5043, 10.1128/MCB.23.14.5043-5055.2003

Shimizu, 2005, ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles, J Cell Biol, 168, 941, 10.1083/jcb.200411179

Rikitake, 2005, Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection, Stroke, 36, 2251, 10.1161/01.STR.0000181077.84981.11

Noma, 2008, ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury, J Clin Invest, 118, 1632, 10.1172/JCI29226

Noma, 2006, Physiological role of ROCKs in the cardiovascular system, Am J Physiol Cell Physiol, 290, C661, 10.1152/ajpcell.00459.2005

Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7

Carton, 2002, RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells, Am J Physiol Cell Physiol, 283, C115, 10.1152/ajpcell.00038.2001

Leung, 1996, The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton, Mol Cell Biol, 16, 5313, 10.1128/MCB.16.10.5313

Fukata, 1999, Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility, J Cell Biol, 145, 347, 10.1083/jcb.145.2.347

O’Cochlain, 2004, Transgenic overexpression of human DMPK accumulates into hypertrophic cardiomyopathy, myotonic myopathy and hypotension traits of myotonic dystrophy, Hum Mol Genet, 13, 2505, 10.1093/hmg/ddh266

Sordella, 2002, Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development, Dev Cell, 2, 553, 10.1016/S1534-5807(02)00162-4

Endres, 1998, Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase, Proc Natl Acad Sci U S A, 95, 8880, 10.1073/pnas.95.15.8880

Rashid, 2009, Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors, Circ J, 73, 361, 10.1253/circj.CJ-08-0817

Wolfrum, 2004, Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection, Arterioscler Thromb Vasc Biol, 24, 1842, 10.1161/01.ATV.0000142813.33538.82

Yoshizumi, 1993, Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life, Circ Res, 73, 205, 10.1161/01.RES.73.1.205

Jimenez, 2001, Regulation of endothelial nitric oxide synthase expression in the vascular wall and in mononuclear cells from hypercholesterolemic rabbits, Circulation, 104, 1822, 10.1161/hc3901.095769

Kataoka, 2002, Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats, Hypertension, 39, 245, 10.1161/hy0202.103271

Bao, 2002, Role of the short isoform of myosin light chain kinase in the contraction of cultured smooth muscle cells as examined by its down-regulation, Proc Natl Acad Sci U S A, 99, 9556, 10.1073/pnas.142298599

Fleming, 2001, Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity, Circ Res, 88, E68, 10.1161/hh1101.092677

Bussemaker, 2007, Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide, Am J Physiol Heart Circ Physiol, 293, H541, 10.1152/ajpheart.00770.2006

Sauzeau, 2000, Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle, J Biol Chem, 275, 21722, 10.1074/jbc.M000753200

Sawada, 2001, cGMP-dependent protein kinase phosphorylates and inactivates RhoA, Biochem Biophys Res Commun, 280, 798, 10.1006/bbrc.2000.4194

Noma, 2005, Smoking, endothelial function, and Rho-kinase in humans, Arterioscler Thromb Vasc Biol, 25, 2630, 10.1161/01.ATV.0000189304.32725.bd

Hidaka, 2010, Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers, Hypertens Res, 33, 354, 10.1038/hr.2010.3

Somlyo, 1998, From pharmacomechanical coupling to G-proteins and myosin phosphatase, Acta Physiol Scand, 164, 437, 10.1046/j.1365-201X.1998.00454.x

Sawada, 2000, Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries, Circulation, 101, 2030, 10.1161/01.CIR.101.17.2030

Abe, 2004, Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats, Circ Res, 94, 385, 10.1161/01.RES.0000111804.34509.94

Masumoto, 2002, Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina, Circulation, 105, 1545, 10.1161/hc1002.105938

Hoka, 2002, Basic and clinical studies on coronary vasospasm, Masui, 51, S151

Shibuya, 2005, Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial, J Neurol Sci, 238, 31, 10.1016/j.jns.2005.06.003

Shimokawa, 2008, Myocardial ischemia: current concepts and future perspectives, J Cardiol, 52, 67, 10.1016/j.jjcc.2008.07.016

Liu, 2008, A method for measuring Rho kinase activity in tissues and cells, Methods Enzymol, 439, 181, 10.1016/S0076-6879(07)00414-4

Nohria, 2006, Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease, Circ Res, 99, 1426, 10.1161/01.RES.0000251668.39526.c7

Liu, 2007, Increased Rho kinase activity in a Taiwanese population with metabolic syndrome, J Am Coll Cardiol, 49, 1619, 10.1016/j.jacc.2006.12.043

Kikuchi, 2011, Enhanced Rho-kinase activity in circulating neutrophils of patients with vasospastic angina: a possible biomarker for diagnosis and disease activity assessment, J Am Coll Cardiol, 58, 1231, 10.1016/j.jacc.2011.05.046

Nohria, 2009, Statins inhibit Rho kinase activity in patients with atherosclerosis, Atherosclerosis, 205, 517, 10.1016/j.atherosclerosis.2008.12.023

Hung, 2012, Increased leukocyte Rho-associated coiled-coil containing protein kinase activity predicts the presence and severity of coronary vasospastic angina, Atherosclerosis, 221, 521, 10.1016/j.atherosclerosis.2012.01.001

Soga, 2011, Rho-associated kinase activity, endothelial function, and cardiovascular risk factors, Arterioscler Thromb Vasc Biol, 31, 2353, 10.1161/ATVBAHA.111.227892