Striatal glutamate and the conversion to psychosis: a prospective 1H-MRS imaging study

International Journal of Neuropsychopharmacology - Tập 16 Số 2 - Trang 471-475 - 2013
Camilo de la Fuente‐Sandoval1,2, Pablo León-Ortíz1, Mariana Azcárraga1, Rafael Favila3, Sylvana Stephano2, Ariel Graff‐Guerrero4
1Experimental Psychiatry Laboratory, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
2Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
3MR Advanced Applications, GE Healthcare, Mexico City, Mexico
4Multimodal Neuroimaging Schizophrenia Group, Research Imaging Centre, Schizophrenia Program, and Geriatric Mental Health Program at Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Canada

Tóm tắt

Abstract Increased glutamate levels in the associative-striatum have been described in subjects at ultra-high risk for psychosis (UHR); nevertheless, it is unclear whether this abnormality predicts the conversion to psychosis. Nineteen subjects at UHR and 26 controls were studied using proton magnetic resonance spectroscopy. Subjects at UHR were clinically followed for 2 yr. Seven UHR subjects (37%) transitioned to a psychotic disorder and the remaining 12 did not exhibit psychotic symptoms at the most recent follow-up. The psychosis transition group had higher glutamate levels compared to both non-transition and control groups (p = 0.02 and p < 0.01, respectively; effect size 1.39). These pilot findings suggest that the conversion to psychosis is associated with increased glutamate levels in the associative-striatum.

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Thông tin xuất bản

International Journal of Neuropsychopharmacology

Tập 16 Số 2

471-475

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