Streptococcus pneumoniae virulence factors and their clinical impact: an update

Girard, 2005, A review of vaccine research and development: Human acute respiratory infections, Vaccine, 50, 5708, 10.1016/j.vaccine.2005.07.046

Reinert, 2004, Pneumococcal conjugate vaccines – a European perspective, Int J Med Microbiol, 294, 277, 10.1016/j.ijmm.2004.04.004

Madhi, 2004, A role for Streptococcus pneumoniae in virus-associated pneumonia, Nat Med, 10, 811, 10.1038/nm1077

Zar, 2004, Pneumonia in HIV-infected and HIV-uninfected children in developing countries: epidemiology, clinical features, and management, Curr Opin Pulm Med, 10, 176, 10.1097/00063198-200405000-00006

Fenoll, 2002, Antimicrobial susceptibility and pneumococcal serotypes, J Antimicrob Chemother, 50, 13, 10.1093/jac/dkf509

Granizo, 2000, 2000. Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and beta-lactam consumption in Spain (1979-1997), J Antimicrob Chemother, 46, 767, 10.1093/jac/46.5.767

Reinert, 2005, Molecular epidemiology of macrolide-resistant Streptococcus pneumoniae isolates in Europe, J Clin Microbiol, 43, 1294, 10.1128/JCM.43.3.1294-1300.2005

Guillemot, 2005, Reduction of antibiotic use in the community reduces the rate of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae, Clin Infect Dis, 41, 930, 10.1086/432721

Frazao, 2005, Effect of the seven-valent conjugate pneumococcal vaccine on carriage and drug resistance of Streptococcus pneumoniae in healthy children attending day-care centers in Lisbon, Pediatr Infect Dis J, 24, 243, 10.1097/01.inf.0000154326.77617.3e

Bogaert, 2004, Colonisation by Streptococcus pneumoniae and Staphylococcus aureus in healthy children, Lancet, 363, 1871, 10.1016/S0140-6736(04)16357-5

Hentzer, 2003, Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections, J Clin Invest, 112, 1300, 10.1172/JCI20074

Jefferies, 2004, Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching, J Clin Microbiol, 42, 5681, 10.1128/JCM.42.12.5681-5688.2004

Hausdorff, 2005, Epidemiological differences among pneumococcal serotypes, Lancet Infect Dis, 5, 83, 10.1016/S1473-3099(05)01280-6

Hanage, 2005, Invasiveness of serotypes and clones of Streptococcus pneumoniae among children in Finland, Infect Immun, 73, 431, 10.1128/IAI.73.1.431-435.2005

Pettigrew, 2005, Genomic subtraction followed by dot blot screening of Streptococcus pneumoniae clinical and carriage isolates identifies genetic differences associated with strains that cause otitis media, Infect Immun, 73, 2805, 10.1128/IAI.73.5.2805-2811.2005

Hammerschmidt, 2005, Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells, Infect Immun, 73, 4653, 10.1128/IAI.73.8.4653-4667.2005

Briles, 2005, Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci, Infect Immun, 73, 6945, 10.1128/IAI.73.10.6945-6951.2005

Jedrzejas, 2001, Pneumococcal virulence factors: structure and function, Microbiol Mol Biol Rev, 65, 187, 10.1128/MMBR.65.2.187-207.2001

Austrian, 2001, Pneumococcal otitis media and pneumococcal vaccines, a historical perspective, Vaccine, 19, 71

Briles, 2000, The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae, Vaccine, 19, 87, 10.1016/S0264-410X(00)00285-1

Bogaert, 2004, Pneumococcal vaccines: an update on current strategies, Vaccine, 22, 2209, 10.1016/j.vaccine.2003.11.038

López, 2004, Recent trends on the molecular biology of pneumococcal capsules, lytic enzymes, and bacteriophage, FEMS Microbiol Rev, 28, 553, 10.1016/j.femsre.2004.05.002

Lee, 2005, Mucosal immunity induced by pneumococcal glycoconjugate, Crit Rev Microbiol, 31, 137, 10.1080/10408410591005093

Harris, 2000, Peptide mimic of phosphorylcholine, a dominant epitope found on Streptococcus pneumoniae, Infect Immun, 68, 5778, 10.1128/IAI.68.10.5778-5784.2000

Kim, 2005, Monoacyl lipoteichoic acid from pneumococci stimulates human cells but not mouse cells, Infect Immun, 73, 834, 10.1128/IAI.73.2.834-840.2005

Boneca, 2005, The role of peptidoglycan in pathogenesis, Curr Opin Microbiol, 8, 46, 10.1016/j.mib.2004.12.008

Carneiro, 2004, Innate immune recognition of microbes through Nod1 and Nod2: implications for disease, Microbes Infect, 6, 609, 10.1016/j.micinf.2004.01.012

Nabors, 2000, Immunization of healthy adults with a single recombinant pneumococcal surface protein A (PspA) variant stimulates broadly cross-reactive antibodies, Vaccine, 18, 1743, 10.1016/S0264-410X(99)00530-7

Coats, 2005, Antibodies to the pneumococcal surface protein A, PspA, can be produced in splenectomized and can protect splenectomized mice from infection with Streptococcus pneumoniae, Vaccine, 23, 4257, 10.1016/j.vaccine.2005.03.039

Gor, 2005, Relationship between surface accessibility for PpmA, PsaA, and PspA and antibody-mediated immunity to systemic infection by Streptococcus pneumoniae, Infect Immun, 73, 1304, 10.1128/IAI.73.3.1304-1312.2005

Berry, 2000, Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins, Infect Immun, 68, 133, 10.1128/IAI.68.1.133-140.2000

Ogunniyi, 2001, Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA, Infect Immun, 69, 5997, 10.1128/IAI.69.10.5997-6003.2001

Ling, 2004, Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse, Clin Exp Immunol, 138, 290, 10.1111/j.1365-2249.2004.02628.x

Guiral, 2005, Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements, Proc Natl Acad Sci, 102, 8710, 10.1073/pnas.0500879102

Seo, 2002, Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin A encapsulated in microspheres, Infect Immun, 70, 1143, 10.1128/IAI.70.3.1143-1149.2002

Jomaa, 2005, Antibodies to the iron uptake ABC transporter lipoproteins PiaA and PiuA promote opsonophagocytosis of Streptococcus pneumoniae, Infect Immun, 73, 6852, 10.1128/IAI.73.10.6852-6859.2005

Overweg, 2000, The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses, Infect Immun, 68, 4180, 10.1128/IAI.68.7.4180-4188.2000

Long, 2004, Immunization with native or recombinant Streptococcus pneumoniae neuraminidase affords protection in the chinchilla otitis media model, Infect Immun, 72, 4309, 10.1128/IAI.72.7.4309-4313.2004

García-Suárez, 2004, Protection against pneumococcal pneumonia in mice by monoclonal antibodies to pneumolysin, Infect Immun, 72, 4534, 10.1128/IAI.72.8.4534-4540.2004

Cockeran, 2005, Pneumolysin as a vaccine and drug target in the prevention and treatment of invasive pneumococcal disease, Arch Immunol Ther Exp, 53, 189

Kadioglu, 2004, The innate immune response to pneumococcal lung infection: the untold story, Trends Immunol, 25, 143, 10.1016/j.it.2003.12.006

Akira, 2006, Pathogen recognition and innate immunity, Cell, 4, 783, 10.1016/j.cell.2006.02.015

Rapola, 2003, Anti-PsaA and the risk of pneumococcal AOM and carriage, Vaccine, 21, 3608, 10.1016/S0264-410X(03)00409-2

McCool, 2003, Serum immunoglobulin G response to candidate vaccine antigens during experimental human pneumococcal colonization, Infect Immun, 71, 5724, 10.1128/IAI.71.10.5724-5732.2003

Holmlund, 2006, Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage, Vaccine, 24, 57, 10.1016/j.vaccine.2005.07.055

Palaniappan, 2005, Differential PsaA-, PspA-, PspC-, and PdB-specific immune responses in a mouse model of pneumococcal carriage, Infect Immun, 73, 1006, 10.1128/IAI.73.2.1006-1013.2005

Johnson, 2002, Inhibition of pneumococcal carriage in mice by subcutaneous immunization with peptides from the common surface protein pneumococcal surface adhesina, J Infect Dis, 185, 489, 10.1086/338928

Lipsitch, 2005, Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?, PLoS Med, 2, e15, 10.1371/journal.pmed.0020015

Malley, 2001, Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci, Infect Immun, 69, 4870, 10.1128/IAI.69.8.4870-4873.2001

Malley, 2005, CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization, Proc Natl Acad Sci, 102, 4848, 10.1073/pnas.0501254102

Cima-Cabal, 1999, Rapid and reliable identification of S. pneumoniae isolates by pneumolysin mediated agglutination?, J Clin Microbiol, 37, 1964, 10.1128/JCM.37.6.1964-1966.1999

Slotved, 2004, Simple, rapid latex agglutination test for serotyping of pneumococci (Pneumotest-Latex), J Clin Microbiol, 42, 2518, 10.1128/JCM.42.6.2518-2522.2004

Petti, 2005, Streptococcus pneumoniae antigen test using positive blood culture bottles as an alternative method to diagnose pneumococcal bacteremia, J Clin Microbiol, 43, 2510, 10.1128/JCM.43.5.2510-2512.2005

Cima-Cabal, 2003, Immunodetection of pneumolysin in human urine by ELISA, J Microbiol Methods, 54, 47, 10.1016/S0167-7012(03)00004-6

Leeming, 2005, Diagnosis of invasive pneumococcal infection by serotype-specific urinary antigen detection, J Clin Microbiol, 43, 4972, 10.1128/JCM.43.10.4972-4976.2005

Díaz-González, 2006, Detection of pneumolysin in human urine using an immunosensor on screen-printed carbon electrodes, Sensors and Actuators B, 113, 1005, 10.1016/j.snb.2005.04.019

Menezes-Martins, 2005, Diagnosis of parapneumonic pleural effusion by polymerase chain reaction in children, J Pediatr Surg, 40, 1106, 10.1016/j.jpedsurg.2005.03.057

Falguera, 2002, Evaluation of the polymerase chain reaction method for detection of Streptococcus pneumoniae DNA in pleural fluid samples, Chest, 122, 2212, 10.1378/chest.122.6.2212

Yang, 2005, Quantitative PCR assay using sputum samples for rapid diagnosis of pneumococcal pneumonia in adult emergency department patients, J Clin Microbiol, 43, 3221, 10.1128/JCM.43.7.3221-3226.2005

Saukkoriipi, 2004, Streptococcus pneumoniae in nasopharyngeal secretions of healthy children: comparison of real-time PCR and culture from STGG-transport medium, Mol Cell Probes, 3, 147, 10.1016/j.mcp.2003.11.003

Cima-Cabal, 2001, A specific and ultrasensitive chemiluminescent sandwich ELISA tests for the detection and quantitation of pneumolysin, J Immunoassay Immunochem, 22, 99, 10.1081/IAS-100103223

Seki, 2005, Loop-mediated isothermal amplification method targeting the lytA gene for detection of Streptococcus pneumoniae, J Clin Microbiol, 4, 1581, 10.1128/JCM.43.4.1581-1586.2005

Batt, 2005, Novel PCR-restriction fragment length polymorphism method for determining serotypes or serogroups of Streptococcus pneumoniae isolates, J Clin Microbiol, 43, 2656, 10.1128/JCM.43.6.2656-2661.2005

O’Halloran, 2005, Multiplex PCR for identification of seven Streptococcus pneumoniae serotypes targeted by a 7-valent conjugate vaccine, J Clin Microbiol, 43, 3487, 10.1128/JCM.43.7.3487-3490.2005

Kong, 2005, A molecular-capsular-type prediction system for 90 Streptococcus pneumoniae serotypes using partial cpsA-cpsB sequencing and wzy- or wzx-specific PCR, J Med Microbiol, 54, 351, 10.1099/jmm.0.45924-0

Hanage, 2005, Using multilocus sequence data to define the pneumococcus, J Bacteriol, 187, 6223, 10.1128/JB.187.17.6223-6230.2005