Strategies for cancer gene therapy

Journal of Surgical Oncology - Tập 85 Số 1 - Trang 28-35 - 2004
Rhiannon Hughes1
1Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. [email protected]

Tóm tắt

AbstractGene therapy offers new opportunities for cancer treatment and prevention through the use of targeted, relatively nontoxic treatments that can identify, disable, and destroy malignant cells. This article reviews the principles behind oncogene inactivation, tumor suppressor gene replacement, inhibition of angiogenesis, immunopotentiation, molecular chemotherapy, and addition of drug resistance genes. The adcantages and limitations of viral and nonviral vectors for delivery of the therapeutic genes are presented. J. Surg. Oncol. 2004;85:28–35. © 2003 Wiley‐Liss, Inc.

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