Steroids and Sesquiterpenes From Cultures of the Fungus Phellinus igniarius

Natural Products and Bioprospecting - Tập 5 - Trang 17-22 - 2014
Rong-Hua Yin1,2, Zhen-Zhu Zhao1,2, Xu Ji1, Ze-Jun Dong1, Zheng-Hui Li1, Tao Feng1, Ji-Kai Liu1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China
2University of Chinese Academy of Sciences, Beijing, China

Tóm tắt

Two new steroids, 3α,17α,19,20-tetrahydroxy-4α-methylpregn-8-ene (1) and 3α,12α,17α,20-tetrahydroxy-4α-methylpregn-8-ene (2) and three new sesquiterpenoids, 12-hydroxy-α-cadinol (3), 3α,12-dihydroxy-δ-cadinol (4), and 3α,6α-dihydroxyspiroax-4-ene (5), have been isolated from cultures of the fungus Phellinus igniarius. Their structures were characterized based on extensive spectroscopic data. In preliminary in vitro assays, compounds 3 and 4 exhibited the vascular-activities against phenylephrine-induced vasoconstriction with the relaxing rates of 11.0 % and 7.0 % at 3 × 10−4 M, respectively.

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