Stereoselective activation of dibenzo[<i>a,l</i>]pyrene to (—)-<i>anti</i>(11<i>R</i>, 12<i>S</i>, 13<i>S</i>, 14<i>R</i>)- and (+)-<i>syn</i>(11<i>S</i>, 12<i>R</i>, 13<i>S</i>, 14<i>R</i>)- 11, 12-diol-13, 14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7

Carcinogenesis - Tập 16 Số 12 - Trang 2899-2907 - 1995
Sherry L. Ralston1, Albrecht Seidel2, Andreas Luch2, Karl L. Platt2, William M. Baird
1Department of Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907 USA
2Institute of Toxicology, University of MainzObere Zahlbacher Str. 67, D-55131 Mainz, Germany

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