Stem cell transplantation for Huntington's disease

Experimental Neurology - Tập 203 - Trang 279-292 - 2007
Stephen B. Dunnett1, Anne E. Rosser1
1The Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, Wales, UK

Tài liệu tham khảo

Andsberg, 1998, Amelioration of ischaemia-induced neuronal death in the rat striatum by NGF-secreting neural stem cells, Eur. J. Neurosci., 10, 2026, 10.1046/j.1460-9568.1998.00214.x Armstrong, 2000, Survival, neuronal integration and fibre outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease, Cell Transplant, 9, 55, 10.1177/096368970000900108 Bachoud-Lévi, 2000, Safety and tolerability assessment of intrastriatal neural allografts in Huntington's disease patients, Exp. Neurol., 161, 194, 10.1006/exnr.1999.7239 Bachoud-Lévi, 2000, Motor and cognitive improvements in patients with Huntington's disease after neural transplantation, Lancet, 356, 1975, 10.1016/S0140-6736(00)03310-9 Bachoud-Lévi, 2006, Persistent benefit of foetal neural transplants in patients with Huntington's disease six years after surgery, Lancet Neurol., 5, 303, 10.1016/S1474-4422(06)70381-7 Beal, 2004, Experimental therapeutics in transgenic mouse models of Huntington's disease, Nat. Rev., Neurosci., 5, 373, 10.1038/nrn1386 Björklund, 1993, Better cells for brain repair, Nature, 362, 414, 10.1038/362414a0 Björklund, 2000, Cell replacement therapies for central nervous system disorders, Nat. Neurosci., 3, 537, 10.1038/75705 Björklund, 2002, Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model, Proc. Natl. Acad. Sci. U. S. A., 99, 2344, 10.1073/pnas.022438099 Björklund, 2003, Neural transplantation for the treatment of Parkinson's disease, Lancet Neurol., 2, 437, 10.1016/S1474-4422(03)00442-3 Borlongan, 1998, Bilateral fetal striatal grafts in the 3-nitropropionic acid-induced hypoactive model of Huntington's disease, Cell Transplant, 7, 131, 10.1177/096368979800700208 Bosch, 2004, Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease, Exp. Neurol., 190, 42, 10.1016/j.expneurol.2004.06.027 Bouhon, 2005, Neural differentiation of mouse embryonic stem cells in chemically defined medium, Brain Res. Bull., 68, 62, 10.1016/j.brainresbull.2005.08.022 Bouhon, 2006, Embryonic stem cell derived neural progenitors display temporal restriction to neural patterning, Stem Cells, 24, 1908, 10.1634/stemcells.2006-0031 Brasted, 1999, Associative plasticity in striatal transplants, Proc. Natl. Acad. Sci. U. S. A., 96, 10524, 10.1073/pnas.96.18.10524 Brasted, 1999, Behavioural recovery following striatal transplantation: effects of postoperative training and P zone volume, Exp. Brain Res., 128, 535, 10.1007/s002210050877 Carter, 1999, Characterisation of progressive motor deficits in mice transgenic for the human Huntington's disease mutation, J. Neurosci., 19, 3248, 10.1523/JNEUROSCI.19-08-03248.1999 Carvey, 2001, A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease, Exp. Neurol., 171, 98, 10.1006/exnr.2001.7735 Catapano, 1999, Differentiation of transplanted neural precursors varies regionally in adult striatum, NeuroReport, 10, 3971, 10.1097/00001756-199912160-00045 Chen, 2000, Intracerebral transplantation of bone marrow with BDNF after MCAo in rat, Neuropharmacology, 39, 711, 10.1016/S0028-3908(00)00006-X Chen, 2001, Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats, Stroke, 32, 2682, 10.1161/hs1101.098367 Chu, 2004, Distribution and in situ proliferation patterns of intravenously injected immortalized human neural stem-like cells in rats with focal cerebral ischemia, Neurosci. Res., 50, 459, 10.1016/j.neures.2004.08.015 Chu, 2004, Human neural stem cells improve sensorimotor deficits in the adult rat brain with experimental focal ischemia, Brain Res., 1016, 145, 10.1016/j.brainres.2004.04.038 Clarke, 1993, Synaptic relationships between cortical and dopaminergic inputs and intrinsic GABAergic systems within intrastriatal striatal grafts, J. Chem. Neuroanat., 6, 147, 10.1016/0891-0618(93)90024-X Clarke, 1994, Internal composition of striatal grafts: light and electron microscopy, 189 Deckel, 1983, Reversal of long-term locomotor abnormalities in the kainic acid model of Huntington's disease by day 18 fetal striatal implants, Eur. J. Pharmacol., 92, 287, 10.1016/0014-2999(83)90150-4 Dihné, 2006, Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain, Stem Cells, 24, 1458, 10.1634/stemcells.2005-0413 Dinsmore, 1996, Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation, Cell Transplant, 5, 131, 10.1177/096368979600500205 Dinsmore, 1998, Embryonic stem cells as a model for studying regulation of cellular differentiation, Theriogenology, 49, 145, 10.1016/S0093-691X(97)00409-3 Döbrössy, 1998, Striatal grafts alleviate deficits in response execution in a lateralised reaction time task, Brain Res. Bull., 47, 585, 10.1016/S0361-9230(98)00129-4 Döbrössy, 2001, The influence of environment and experience on neural grafts, Nat. Rev., Neurosci., 2, 871, 10.1038/35104055 Dunnett, 1995, Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction, Behav. Brain Res., 66, 133, 10.1016/0166-4328(94)00134-2 Dunnett, 2000, Functional analysis of fronto-striatal reconstruction by striatal grafts, vol. 231, 21 Dunnett, S.B., Rosser, A.E., in press. Cell transplantation for Huntington's disease. Should we continue? Brain Res. Bull. Dunnett, 2006, Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat, Exp. Neurol., 199, 479, 10.1016/j.expneurol.2006.01.013 Dunnett, 1988, Striatal grafts in rats with unilateral neostriatal lesions. III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching, Neuroscience, 24, 813, 10.1016/0306-4522(88)90069-3 Dunnett, 1998, Striatal transplantation in a transgenic mouse model of Huntington's disease, Exp. Neurol., 154, 31, 10.1006/exnr.1998.6926 Dunnett, 2000, The integration and function of striatal grafts, Prog. Brain Res., 127, 345, 10.1016/S0079-6123(00)27017-9 Dunnett, 2005, Frontal–striatal disconnection disrupts cognitive performance of the frontal-type in the rat, Neuroscience, 155, 1055, 10.1016/j.neuroscience.2005.07.033 Emerich, 1996, Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease, J. Neurosci., 16, 5168, 10.1523/JNEUROSCI.16-16-05168.1996 Emerich, 1997, Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease, Cell Transplant, 6, 249, 10.1177/096368979700600308 Emerich, 1997, Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease, Nature, 386, 395, 10.1038/386395a0 Emerich, 1998, Cellular delivery of CNTF but not NT-4/5 prevents degeneration of striatal neurons in a rodent model of Huntington's disease, Cell Transplant, 7, 213, 10.1177/096368979800700215 Ende, 2001, Human umbilical cord blood cells ameliorate Huntington's disease in transgenic mice, J. Med., 32, 231 Erdö, 2003, Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke, J. Cereb. Blood Flow Metab., 23, 780, 10.1097/01.WCB.0000071886.63724.FB Eriksson, 2003, Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions, Exp. Neurol., 184, 615, 10.1016/S0014-4886(03)00271-1 Freeman, 2000, Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology, Proc. Natl. Acad. Sci. U. S. A., 97, 13877, 10.1073/pnas.97.25.13877 French, 2002, Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia, Immunol. Rev., 187, 22, 10.1034/j.1600-065X.2002.18703.x Fricker, 1997, The effects of donor stage on the survival and function of embryonic striatal grafts. II. Correlation between positron emission tomography and reaching behaviour, Neuroscience, 79, 711, 10.1016/S0306-4522(96)00657-4 Fricker-Gates, 2000, EGF infusion stimulates the proliferation and migration of embryonic progenitor cells transplanted in the adult rat striatum, Exp. Neurol., 165, 237, 10.1006/exnr.2000.7482 Fricker-Gates, 2004, Transplanted hNT cells (‘LBS neurons’) in a rat model of Huntington's disease: good survival, incomplete differentiation and no functional recovery, Cell Transplant, 13, 123, 10.3727/000000004773301807 Fricker-Gates, 2004, Striatal neurons in striatal grafts are derived from both post-mitotic cells and dividing progenitors, Eur. J. Neurosci., 19, 513, 10.1111/j.1460-9568.2004.03149.x Gage, 1995, Isolation, characterization, and use of stem cells from the CNS, Annu. Rev. Neurosci., 18, 159, 10.1146/annurev.ne.18.030195.001111 Grasbon-Frodl, 1997, Developmental features of human striatal tissue transplanted in a rat model of Huntington's disease, Neurobiol. Dis., 3, 299, 10.1006/nbdi.1996.0124 Graybiel, 1989, Intrastriatal grafts derived from fetal striatal primordia: 1. Phenotypy and modular organization, J. Neurosci., 9, 3250, 10.1523/JNEUROSCI.09-09-03250.1989 Helm, 1992, Descriptive morphology of developing fetal neostriatal allografts in the rhesus monkey: a correlated light and electron microscopic golgi study, Neuroscience, 50, 163, 10.1016/0306-4522(92)90390-N Herrera, 1999, Adult-derived neural precursors transplanted into multiple regions in the adult brain, Ann. Neurol., 46, 867, 10.1002/1531-8249(199912)46:6<867::AID-ANA9>3.0.CO;2-Z Hurlbert, 1999, Neural transplantation of hNT neurons for Huntington's disease, Cell Transplant, 8, 143, 10.1177/096368979900800106 Isacson, 1986, Graft-induced behavioral recovery in an animal model of Huntington disease, Proc. Natl. Acad. Sci. U. S. A., 83, 2728, 10.1073/pnas.83.8.2728 Jain, 2003, GABAergic immunoreactivity is predominant in neurons derived from expanded human neural precursor cells in vitro, Exp. Neurol., 182, 113, 10.1016/S0014-4886(03)00055-4 Jeong, 2003, Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage, Stroke, 34, 2258, 10.1161/01.STR.0000083698.20199.1F Kendall, 1998, Functional integration of striatal allografts in a primate model of Huntington's disease, Nat. Med., 4, 727, 10.1038/nm0698-727 Kim, 2002, Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease, Nature, 418, 50, 10.1038/nature00900 Kopyov, 1998, Safety of intrastriatal neurotransplantation for Huntington's disease patients, Exp. Neurol., 119, 97, 10.1006/exnr.1997.6685 Kordower, 1997, Grafts of EGF-responsive neural stem cells derived from GFAP-hNGF transgenic mice: trophic and tropic effects in a rodent model of Huntington's disease, J. Comp. Neurol., 387, 96, 10.1002/(SICI)1096-9861(19971013)387:1<96::AID-CNE8>3.0.CO;2-I Lee, 2005, Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model, Neurosci. Res., 52, 243, 10.1016/j.neures.2005.03.016 Lee, 2006, Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease, J. Neurosci. Methods, 152, 250, 10.1016/j.jneumeth.2005.09.013 Lescaudron, 2003, Autologous adult bone marrow stem cell transplantation in an animal model of huntington's disease: behavioral and morphological outcomes, Int. J. Neurosci., 113, 945, 10.1080/00207450390207759 Levivier, 2003, Human frtysl neural transplants in patients with PD: ethical considerations, Lancet Neurol., 2, 441 Lione, 1999, Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation, J. Neurosci., 19, 10428, 10.1523/JNEUROSCI.19-23-10428.1999 Lois, 1993, Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia, Proc. Natl. Acad. Sci. U. S. A., 90, 2074, 10.1073/pnas.90.5.2074 Lundberg, 1996, Conditionally immortalized neural progenitor cell lines integrate and differentiate after grafting to the adult rat striatum. A combined autoradiographic and electron microscopic study, Brain Res., 737, 295, 10.1016/0006-8993(96)00923-7 Lundberg, 1996, Conditionally immortalised neural progenitor cells grafted to the striatum exhibit site-specific neuronal differentiation and establish connections with the host globus pallidus, Neurobiol. Dis., 3, 33, 10.1006/nbdi.1996.0004 Lundberg, 1997, Survival, integration, and differentiation of neural stem cell lines after transplantation to the adult rat striatum, Exp. Neurol., 145, 342, 10.1006/exnr.1997.6503 Lundberg, 2002, Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain, Exp. Neurol., 175, 370, 10.1006/exnr.2002.7888 Martinez-Serrano, 1996, Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells, J. Neurosci., 16, 4604, 10.1523/JNEUROSCI.16-15-04604.1996 Mayer, 1992, Striatal graft-associated recovery of a lesion-induced performance deficit in the rat requires learning to use the transplant, Eur. J. Neurosci., 4, 119, 10.1111/j.1460-9568.1992.tb00858.x Mazzocchi-Jones, 2005, Striatal grafts and synaptic plasticity, 313 McBride, 2004, Human neural stem cell transplants improve motor function in a rat model of Huntington's disease, J. Comp. Neurol., 475, 211, 10.1002/cne.20176 Menalled, 2002, Mouse models of Huntington's disease, Trends Pharmacol. Sci., 23, 32, 10.1016/S0165-6147(00)01884-8 Modo, 2002, Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging, NeuroImage, 17, 803, 10.1006/nimg.2002.1194 Morton, 2000, Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation, J. Neurocytol., 29, 679, 10.1023/A:1010887421592 Nakao, 1996, DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease, Neuroscience, 74, 959, 10.1016/0306-4522(96)00238-2 Nakao, 1999, Embryonic striatal grafts restore neuronal activity of the globus pallidus in a rodent model of Huntington's disease, Neuroscience, 88, 469, 10.1016/S0306-4522(98)00197-3 Newman, 2004, Transplantation of human umbilical cord blood cells in the repair of CNS diseases, Expert Opin. Biol. Ther., 4, 121, 10.1517/14712598.4.2.121 Newman, 2005, Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells, Stem Cells Dev., 14, 29, 10.1089/scd.2005.14.29 Nishino, 2000, Restoration of function by neural transplantation in the ischaemic brain, Prog. Brain Res., 127, 461, 10.1016/S0079-6123(00)27022-2 Nishino, 1993, Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance, Brain Res. Bull., 32, 517, 10.1016/0361-9230(93)90300-Z Olsson, 1995, Projection neurons in fetal striatal transplants are predominantly derived from the lateral ganglionic eminence, Neuroscience, 69, 1169, 10.1016/0306-4522(95)00325-D Olsson, 1997, Extensive migration and target innervation by striatal precursors after grafting into the neonatal striatum, Neuroscience, 79, 57, 10.1016/S0306-4522(96)00606-9 Olsson, 1997, Specification of mouse telencephalic and mid-hindbrain progenitors following heterotopic ultrasound-guided embryonic transplantation, Neuron, 19, 761, 10.1016/S0896-6273(00)80959-9 Olsson, 1998, Incorporation of mouse neural progenitors transplanted into the rat embryonic forebrain is developmentally regulated and dependent on regional and adhesive properties, Eur. J. Neurosci., 10, 71, 10.1046/j.1460-9568.1998.00015.x Olsson, 1998, Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence, Neuroscience, 84, 867, 10.1016/S0306-4522(97)00532-0 Pakzaban, 1993, Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence, Exp. Brain Res., 97, 13, 10.1007/BF00228813 Palfi, 1998, Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington's disease, Nat. Med., 4, 963, 10.1038/nm0898-963 Reynolds, 1992, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, 255, 1707, 10.1126/science.1553558 Reynolds, 1992, A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes, J. Neurosci., 12, 4565, 10.1523/JNEUROSCI.12-11-04565.1992 Roberts, 2006, Preservation of striatal tissue and behavioral function after neural stem cell transplantation in a rat model of Huntington's disease, Neuroscience, 139, 1187, 10.1016/j.neuroscience.2006.01.025 Rodriguez, 2003, Effects of Sertoli cell transplants in a 3-nitropropionic acid model of early Huntington's disease: a preliminary study, Neurotox. Res., 5, 443, 10.1007/BF03033174 Rosser, 2002, Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no 36485475), J. Neurol. Neurosurg. Psychiatry, 73, 678, 10.1136/jnnp.73.6.678 Roy, 2006, Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes, Nat. Med., 12, 1259, 10.1038/nm1495 Rutherford, 1987, Electrophysiological demonstration of host cortical inputs to striatal grafts, Neurosci. Lett., 83, 275, 10.1016/0304-3940(87)90099-1 Ryu, 2004, Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease, Neurobiol. Dis., 16, 68, 10.1016/j.nbd.2004.01.016 Saporta, 1998, In vitro cell viability and in vivo survival of hNT neurons correlate with behavioral recovery of grafted ischemic rats, Exp. Neurol., 153, 391 Saporta, 2000, In vitro and in vivo characterization of hNT neuron neurotransmitter phenotypes, Brain Res. Bull., 53, 263, 10.1016/S0361-9230(00)00329-4 Saporta, 2001, Comparison of calcium-binding proteins expressed in cultured hNT neurons and hNT neurons transplanted into the rat striatum, Exp. Neurol., 167, 252, 10.1006/exnr.2000.7550 Schouten, 2004, A review and rationale for the use of cellular transplantation as a therapeutic strategy for traumatic brain injury, J. Neurotrauma, 21, 1501, 10.1089/neu.2004.21.1501 Shihabuddin, 1995, The adult CNS retains the potential to direct region-specific differentiation of a transplanted neuronal precursor cell line, J. Neurosci., 15, 6666, 10.1523/JNEUROSCI.15-10-06666.1995 Sinclair, 1999, Dopamine cells in nigral grafts differentiate prior to implantation, Eur. J. Neurosci., 11, 4341, 10.1046/j.1460-9568.1999.00867.x Sirinathsinghji, 1988, Striatal grafts in rats with unilateral neostriatal lesions: II. In vivo monitoring of GABA release in globus pallidus and substantia nigra, Neuroscience, 24, 803, 10.1016/0306-4522(88)90068-1 Sirinathsinghji, 1993, Cholecystokinin-dependent regulation of host dopamine inputs to striatal grafts, Neuroscience, 53, 651, 10.1016/0306-4522(93)90613-K Sramka, 1992, Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea, Stereotact. Funct. Neurosurg., 58, 79, 10.1159/000098976 Svendsen, 1996, Survival and differentiation of rat and human EGF responsive precursor cells following grafting into the lesioned adult CNS, Exp. Neurol., 137, 376, 10.1006/exnr.1996.0039 Tao, 2003, Evidence for transdifferentiation of human bone marrow-derived stem cells: recent progress and controversies, Pathology, 35, 6, 10.1080/003130202201471 Toda, 2001, Grafting neural stem cells improved the impaired spatial recognition in ischemic rats, Exp. Neurol., 165, 66, 10.1006/exnr.2000.7473 Tsai, 2002, Plasticity, niches, and the use of stem cells, Dev. Cell, 2, 707, 10.1016/S1534-5807(02)00195-8 Uchida, 2005, Potential functional neural repair with grafted neural stem cells of early embryonic neuroepithelial origin, Neurosci. Res., 52, 276, 10.1016/j.neures.2005.03.015 van Dellen, 2001, Anterior cingulate cortical transplantation in transgenic Huntington's disease mice, Brain Res. Bull., 56, 313, 10.1016/S0361-9230(01)00655-4 Vazey, 2006, Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease, Exp. Neurol., 199, 384, 10.1016/j.expneurol.2006.01.034 Vendrame, 2004, Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume, Stroke, 35, 2390, 10.1161/01.STR.0000141681.06735.9b Vendrame, 2005, Anti-inflammatory effects of human cord blood cells in a rat model of stroke, Stem Cells Dev., 14, 595, 10.1089/scd.2005.14.595 Visnyei, 2006, Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion, Exp. Neurol., 197, 465, 10.1016/j.expneurol.2005.10.023 Wagers, 2004, Plasticity of adult stem cells, Cell, 116, 639, 10.1016/S0092-8674(04)00208-9 Watts, 1997, Effect of embryonic donor age and dissection on the DARPP-32 content of cell suspensions used for intrastriatal transplantation, Exp. Neurol., 148, 271, 10.1006/exnr.1997.6646 White, 2006, Fronto-striatal disconnection disrupts operant delayed alternation performance in the rat, NeuroReport, 17, 435, 10.1097/01.wnr.0000203625.09706.5d Whittemore, 2000, Immortalized neural cell lines for CNS transplantation, Prog. Brain Res., 127, 49, 10.1016/S0079-6123(00)27005-2 Wictorin, 1992, Anatomy and connectivity of intrastriatal striatal transplants, Prog. Neurobiol., 38, 611, 10.1016/0301-0082(92)90044-F Xu, 1991, Synaptic potentials evoked in spiny neurons in rat neostriatal grafts by cortical and thalamic stimulation, J. Neurophysiol., 65, 477, 10.1152/jn.1991.65.3.477 Zhang, 2003, Migration and differentiation of adult rat subventricular zone progenitor cells transplanted into the adult rat striatum, Neuroscience, 116, 373, 10.1016/S0306-4522(02)00696-6 Zietlow, 2005, The survival of neural precursor cell grafts is influenced by in vitro expansion, J. Anat., 207, 227, 10.1111/j.1469-7580.2005.00449.x