Stem Cell Therapy for Erectile Dysfunction: Progress and Future Directions

Sexual Medicine Reviews - Tập 1 - Trang 50-64 - 2013
Maarten Albersen1, Emmanuel Weyne1, Trinity J. Bivalacqua2
1Laboratory for Experimental Urology, Gene and Stem Cells Applications, Department of Development and Regeneration, University of Leuven, Leuven, Belgium
2The James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA

Tài liệu tham khảo

NIH Consensus Conference, 1993, Impotence. NIH Consensus Development Panel on Impotence, JAMA, 270, 83, 10.1001/jama.1993.03510010089036 Gratzke, 2010, Anatomy, physiology, and pathophysiology of erectile dysfunction, J Sex Med, 7, 445, 10.1111/j.1743-6109.2009.01624.x Shin, 2011, Erectile dysfunction: A disease marker for cardiovascular disease, Cardiol Rev, 19, 5, 10.1097/CRD.0b013e3181fb7eb8 Mulhall, 2013, Standard operating procedure for the preservation of erectile function outcomes after radical prostatectomy, J Sex Med, 10, 195, 10.1111/j.1743-6109.2012.02885.x Guay, 2001, Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors, J Androl, 22, 793 Hanson‐Divers, 1998, Health outcomes variables important to patients in the treatment of erectile dysfunction, J Urol, 159, 1541, 10.1097/00005392-199805000-00037 Becker, 1963, Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells, Nature, 197, 452, 10.1038/197452a0 Thomson, 1998, Embryonic stem cell lines derived from human blastocysts, Science, 282, 1145, 10.1126/science.282.5391.1145 Albersen, 2012, Multipotent stromal cell therapy for cavernous nerve injury‐induced erectile dysfunction, J Sex Med, 9, 385, 10.1111/j.1743-6109.2011.02556.x Friedenstein, 1968, Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues, Transplantation, 6, 230, 10.1097/00007890-196803000-00009 Dominici, 2006, Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement, Cytotherapy, 8, 315, 10.1080/14653240600855905 Zhang, 2011, Stem cells: Novel players in the treatment of erectile dysfunction, Asian J Androl, 14, 145, 10.1038/aja.2011.79 Zuk, 2002, Human adipose tissue is a source of multipotent stem cells, Mol Biol Cell, 13, 4279, 10.1091/mbc.E02-02-0105 Corselli, 2010, Perivascular ancestors of adult multipotent stem cells, Arterioscler Thromb Vasc Biol, 30, 1104, 10.1161/ATVBAHA.109.191643 Gimble, 2011, Concise review: Adipose‐derived stromal vascular fraction cells and stem cells: Let's not get lost in translation, Stem Cells, 29, 749, 10.1002/stem.629 Casteilla, 2011, Adipose‐derived stromal cells: Their identity and uses in clinical trials, an update, World J Stem Cells, 3, 25, 10.4252/wjsc.v3.i4.25 Qiu, 2012, Both immediate and delayed intracavernous injection of autologous adipose‐derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury, Eur Urol, 62, 720, 10.1016/j.eururo.2012.02.003 Albersen, 2008, Preclinical evidence for the benefits of penile rehabilitation therapy following nerve‐sparing radical prostatectomy, Adv Urol, 594868 Leungwattanakij, 2003, Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum, J Androl, 24, 239, 10.1002/j.1939-4640.2003.tb02668.x Bochinski, 2004, The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury, BJU Int, 94, 904, 10.1111/j.1464-410X.2003.05057.x Kim, 2006, Injection of skeletal muscle‐derived cells into the penis improves erectile function, Int J Impot Res, 18, 329, 10.1038/sj.ijir.3901434 Fall, 2009, Apoptosis and effects of intracavernous bone marrow cell injection in a rat model of postprostatectomy erectile dysfunction, Eur Urol, 56, 716, 10.1016/j.eururo.2008.09.059 Kendirci, 2010, Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury, J Urol, 184, 1560, 10.1016/j.juro.2010.05.088 Albersen, 2010, Injections of adipose tissue‐derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury, J Sex Med, 7, 3331, 10.1111/j.1743-6109.2010.01875.x Fandel, 2011, Recruitment of intracavernously injected adipose‐derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury, Eur Urol, 61, 201, 10.1016/j.eururo.2011.07.061 Woo, 2011, Transplantation of muscle‐derived stem cells into the corpus cavernosum restores erectile function in a rat model of cavernous nerve injury, Korean J Urol, 52, 359, 10.4111/kju.2011.52.5.359 Lin, 2011, Tracking intracavernously injected adipose‐derived stem cells to bone marrow, Int J Impot Res, 23, 268, 10.1038/ijir.2011.38 Qiu, 2012, Effects of intravenous injection of adipose‐derived stem cells in a rat model of radiation therapy‐induced erectile dysfunction, J Sex Med, 9, 1834, 10.1111/j.1743-6109.2012.02753.x Kim, 2012, Effect of mesenchymal stem cells associated to matrixen on the erectile function in the rat model with bilateral cavernous nerve crushing injury, Int Braz J Urol, 38, 833, 10.1590/1677-553820133806833 Piao, 2012, Therapeutic effect of adipose‐derived stem cells and BDNF‐immobilized PLGA membrane in a rat model of cavernous nerve injury, J Sex Med, 10.1111/j.1743-6109.2012.02760.x Ying, 2013, Effects of intracavernous injection of adipose‐derived stem cells on cavernous nerve regeneration in a rat model, Cell Mol Neurobiol, 33, 233, 10.1007/s10571-012-9890-7 Kim, 2013, Effect of an adipose‐derived stem cell and nerve growth factor‐incorporated hydrogel on recovery of erectile function in a rat model of cavernous nerve injury, Tissue Eng Part A, 19, 14, 10.1089/ten.tea.2011.0654 You, 2013, Periprostatic implantation of human bone marrow‐derived mesenchymal stem cells potentiates recovery of erectile function by intracavernosal injection in a rat model of cavernous nerve injury, Urology, 81, 104, 10.1016/j.urology.2012.08.046 You, 2013, Comparative analysis of periprostatic implantation and intracavernosal injection of human adipose tissue‐derived stem cells for erectile function recovery in a rat model of cavernous nerve injury, Prostate, 73, 278, 10.1002/pros.22567 Albersen, 2011, Re: Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. M. Kendirci, L. Trost, B. Bakondi, M. J. Whitne, J Urol, 185, 1158, 10.1016/j.juro.2010.10.073 Zhang, 2011, Adipose tissue‐derived stem cells secrete CXCL5 cytokine with neurotrophic effects on cavernous nerve regeneration, J Sex Med, 8, 437, 10.1111/j.1743-6109.2010.02128.x Lin, 2009, Labeling and tracking of mesenchymal stromal cells with EdU, Cytotherapy, 11, 864, 10.3109/14653240903180084 Baek, 2011, In vitro migration capacity of human adipose tissue‐derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors, Exp Mol Med, 43, 596, 10.3858/emm.2011.43.10.069 Augello, 2010, Mesenchymal stem cells: A perspective from in vitro cultures to in vivo migration and niches, Eur Cells Mater, 20, 121, 10.22203/eCM.v020a11 Lin, 2011, Cavernous nerve repair with allogenic adipose matrix and autologous adipose‐derived stem cells, Urology, 77, 1509, 10.1016/j.urology.2010.12.076 Bivalacqua, 2007, Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age‐associated erectile dysfunction, Am J Physiol Heart Circ Physiol, 292, H1278, 10.1152/ajpheart.00685.2006 Abdel Aziz, 2010, Effect of mesenchymal stem cell penile transplantation on erectile signaling of aged rats, Andrologia, 42, 187, 10.1111/j.1439-0272.2009.00977.x Nolazco, 2008, Effect of muscle‐derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat, BJU Int, 101, 1156, 10.1111/j.1464-410X.2008.07507.x Garcia, 2010, Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue‐derived stem cells, J Sex Med, 7, 89, 10.1111/j.1743-6109.2009.01541.x Huang, 2010, The effect of intracavernous injection of adipose tissue‐derived stem cells on hyperlipidemia‐associated erectile dysfunction in a rat model, J Sex Med, 7, 1391, 10.1111/j.1743-6109.2009.01697.x Qiu, 2011, Intracavernous transplantation of bone marrow‐derived mesenchymal stem cells restores erectile function of streptozocin‐induced diabetic rats, J Sex Med, 8, 427, 10.1111/j.1743-6109.2010.02118.x Sun, 2012, Neurotrophic effect of bone marrow mesenchymal stem cells for erectile dysfunction in diabetic rats, Int J Androl, 35, 601, 10.1111/j.1365-2605.2012.01250.x Qiu, 2012, Combined strategy of mesenchymal stem cell injection with vascular endothelial growth factor gene therapy for the treatment of diabetes‐associated erectile dysfunction, J Androl, 33, 37, 10.2164/jandrol.110.012666 Ryu, 2012, Intracavernous delivery of freshly isolated stromal vascular fraction rescues erectile function by enhancing endothelial regeneration in the streptozotocin‐induced diabetic mouse, J Sex Med, 9, 3051, 10.1111/j.1743-6109.2012.02962.x Nishimatsu, 2012, Adrenomedullin mediates adipose tissue‐derived stem cell‐induced restoration of erectile function in diabetic rats, J Sex Med, 9, 482, 10.1111/j.1743-6109.2011.02469.x Castiglione, 2013, Intratunical injection of human adipose tissue‐derived stem cells prevents fibrosis and is associated with improved erectile function in a rat model of Peyronie's disease, Eur Urol, 63, 551, 10.1016/j.eururo.2012.09.034 Salgado, 2010, Adipose tissue derived stem cells secretome: Soluble factors and their roles in regenerative medicine, Curr Stem Cell Res Ther, 5, 103, 10.2174/157488810791268564 Ferretti, 2012, Stem cell therapy for Peyronie's disease: Morphological and functional outcomes of intraplaque injection of adipose‐derived stem cells on a rat model of Peyronie's disease, J Sex Med., 9, 311 An, 2012, The therapeutic role of VEGF‐expressing muscle‐derived stem cells in acute penile cavernosal injury, J Sex Med, 10.1111/j.1743-6109.2012.02827.x Kim, 2012, Allogenic adipose derived stem cell transplantation in rats with erectile dysfunction induced by bilateral cavernous nerve crushing injury, J Sex Med, 9, 375 Hakim, 2012, Emerging tools for erectile dysfunction: A role for regenerative medicine, Nat Rev Urol, 9, 520, 10.1038/nrurol.2012.143 Cellek, 2012, Common pitfalls in some of the experimental studies in erectile function and dysfunction: A consensus article, J Sex Med, 9, 2770, 10.1111/j.1743-6109.2012.02916.x Bahk, 2010, Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: Preliminary report of 7 cases, Exp Clin Transplant, 8, 150 Ning, 2013, Effects of EdU labeling on mesenchymal stem cells, Cytotherapy, 15, 57, 10.1016/j.jcyt.2012.10.010