Statins are associated with decreased mortality in abdominal, but not in thoracic aortic aneurysm patients undergoing endovascular repair: propensity score-adjusted analysis

Vasa - European Journal of Vascular Medicine - Tập 37 Số 3 - Trang 241-249 - 2008
Diehm1, Becker2, Katzen3, Benenati3, Kovacs3, Florian Dick4
1Department of Heart and Vessel, Division of Angiology Inselspital, Bern University Hospital, and University of Bern, Switzerland.
2Department of Radiology, Vascular & Interventional Section, and the Sarver Heart Center, University of Arizona College of Medicine
3Baptist Cardiac and Vascular Institute, Miami, FL, USA
4Klinik für Herz- und Gefässchirurgie, Inselspital, Universitätsspital Bern, Schweiz

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Background: Purpose of this study was to compare the correlation of statin use with long-term mortality in patients with abdominal (AAA) and thoracic aortic aneurysm (TAA). Patients and methods: We compared long-term survival of 731 AAA and 59 TAA patients undergoing elective endovascular repair (EVAR). Kaplan-Meier survival curves were compared by the log-rank method. Propensity score-adjusted multivariable logistic regression models were used to determine independent associations of statin use on vital status after EVAR. Results: Statin use was associated with decreased long-term mortality in AAA patients in bivariate and multivariable regression analysis, in which the effect of propensity to receive a statin was considered (adjusted HR: .613, 95%-CI: .379– .993, p = .047) whereas mortality of TAA patients was not associated with use of statins (adjusted HR: 1.795, 95%-CI: .147 –21.942, p = .647). Conclusions: Use of statins is an independent predictor of decreased mortality after elective EVAR in AAA, but not in TAA patients. These findings indirectly support the concept of a distinct pathogenesis of AAA and TAA.

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Vasa - European Journal of Vascular Medicine

Tập 37 Số 3

241-249

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