Harit Desai1, Wilbert S. Aronow1, Fausan S. Tsai1, Chul Ahn2, Hoang M. Lai1, Harshad Amin1, Kaushang Gandhi1, William H. Frishman1, Martin Cohen1, Carmine Sorbera1
1Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York
2Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas
Tóm tắt
Of 209 patients with heart failure treated with combined cardiac resynchronization therapy and implantable cardioverter-defibrillator therapy, appropriate cardioverter-defibrillator shocks occurred at 34-month follow-up in 22 of 121 patients (18%) on statins and in 30 of 88 patients (34%) not on statins (P = .009). Deaths occurred in 3 of 121 patients (2%) on statins and in 9 of 88 patients (10%) not on statins (P = .017). Stepwise Cox regression analysis showed that significant independent prognostic factors for appropriate shocks were use of statins (risk ratio = 0.46), smoking (risk ratio = 3.5), and diabetes (risk ratio = 0.34). Significant independent prognostic factors for the time to mortality were use of statins (risk ratio = 0.05), use of digoxin (risk ratio = 4.2), systemic hypertension (risk ratio = 14.2), diabetes (risk ratio = 4.3), and left ventricular ejection fraction (risk ratio = 1.1).
