Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females

Oxford University Press (OUP) - Tập 3 Số 2 - Trang 133-144 - 1988
Robert R. Recker1, Donald B. Kimmel1, Michael A. Parfitt2, Michael K. Davies1, N.M. Keshawarz1, Sharilyn M. Hinders1
1Center for Hard Tissue Research, Dept. of Medicine, Creighton University, Omaha, NE
2Bone and Mineral Division, Henry Ford Hospital, Detroit, MI

Tóm tắt

Abstract Transilial bone biopsies were obtained from 34 healthy postmenopausal women following in vivo fluorochrome labeling. Stained and unstained undecalcified sections were evaluated using a Merz grid. Standard histomorphometric data from cancellous bone tissue were collected and the results were evaluated and presented as variables commonly used in bone histomorphometry. The normal ranges, medians, means, and standard deviations for the group of 34 are presented in tabular form for structural, surface, basic dynamic, and derived dynamic data. Similar data for individuals grouped by ages 45–54, 55–64, and 65–74 are also presented. Secular trends for the whole group are evaluated. The structural and surface data are not much different from previous reports of sudden-death accident victims, when methodologic differences are considered. The mineral apposition rate (MAR) was 0.53 ± 0.08 μm/day, similar to previous reports in cancellous bone, but one-third less than in cortical bone. MAR showed a marked decline with age. In contrast, the extent of tetracycline-labeled surfaces varied widely without a secular trend. Double-label surface (dLS/BS) ranged from 0.5 to 8.0% and single-label surface (sLS/BS), from 0.5 to 10.5%. Mineralizing osteoid surface (MS/OS) varied from 2 to 64%. Using only double-label surface to represent mineralizing surface, volumebased bone formation rate (BFR/BV) ranged from 0.7 to 28%/yr, and the remodeling period (Rm.P) varied from 0.28 to 4.5 years. Calculations using other representations of mineralizing surface [double plus one-half single label (MS/BS″); all label (MS/BS′)] are also presented. These bone histomorphometric data are important because: (1) they come from a cohort of living subjects that was recruited solely for the purpose of establishing normal bone histomorphometry; (2) they represent the age range of patients with postmenopausal osteoporosis; and (3) they markedly expand the bone histomorphometric database of healthy persons given in vivo fluorochrome labeling prior to transilial biopsy.

Từ khóa


Tài liệu tham khảo

Frost, 1969, Tetracycline-based histological analysis of bone remodeling, Calc Tiss Res, 3, 211, 10.1007/BF02058664

Parfitt, 1983, Bone Histomor-phometry: Techniques and Interpretation, 143

Beck, 1960, Histological assessment of osteoporosis by iliac crest biopsy, J Path Bact, 80, 391, 10.1002/path.1700800223

Garner, 1966, Quantitative observations on mineralized and unmineralized bone in chronic renal azotaemia and intestinal malabsorption syndrome, J Path Bact, 91, 545, 10.1002/path.1700910231

Schenk, 1969, A quantitative histological study on bone resorption in human cancellous bone, Acta Anat, 74, 44, 10.1159/000143361

Merz, 1970, A quantitative histological study on bone formation in human cancellous bone, Acta Anat, 76, 1, 10.1159/000143476

Merz, 1970, Quantitative structural analysis of human cancellous bone, Acta Anat, 76, 35, 10.1159/000143476

Bordier, 1972, Quantitative histology of metabolic bone disease, Clin Endo Metab, 1, 197, 10.1016/S0300-595X(72)80057-4

Ellis, 1972, Quantitative observations on mineralized and non-mineralized bone in the iliac crest, J Clin Path, 25, 277, 10.1136/jcp.25.4.277

Meunier, 1973, Physiological senile involution and pathological rarefaction of bone. Quantitative and comparative histological data, Clin Endo Metab, 2, 239, 10.1016/S0300-595X(73)80042-8

Garrick, 1972, Quantitative histology of bone: the use of a computer program and results in normal subjects, Clin Sci, 43, 789, 10.1042/cs0430789

Delling, 1974, Age-related bone changes, Cur Topics Pathol, 58, 118

Melsen, 1978, Histomorphometric analysis of normal bone from the iliac crest, Acta Path Micro Scan, 86A, 70

Xipell, 1979, Histology of normal bone—a computerized study in the iliac crest, Pathology, 11, 235, 10.1016/S0031-3025(16)39896-8

Hoikka, 1981, Histomorphometric normal values of the iliac crest cancellous bone in a Finnish autopsy series, Ann Clin Res, 13, 383

Malluche, 1982, Quantitative bone histoogy in 84 normal American subjects, Calc Tiss Int, 34, 449, 10.1007/BF02411283

Marcus, 1983, Age-related loss of trabecular bone in premenopausal women: a biopsy study, Calc Tiss Int, 35, 406, 10.1007/BF02405068

Perrine, 1975, Alcohol involvement in highway crashes: a review of the epidemiologic evidence, Clin Plast Surg, 2, 11, 10.1016/S0094-1298(20)30093-6

Soderstrom, 1984, Alcohol consumption among vehicular occupants injured in crashes, Alcoholism: Clin Exp Res, 8, 269, 10.1111/j.1530-0277.1984.tb05509.x

Recker, 1983, Clinical Disorders of Bone and Mineral Metabolism, 227

Vedi, 1982, Histomorphometric analysis of bone biopsies from the iliac crest of normal British subjects, Metab Bone Dis Rel Res, 4, 231, 10.1016/0221-8747(82)90032-7

Vedi, 1983, Histomorphometric analysis of dynamic parameters of trabecular bone formation in the iliac crest of normal British subjects, Metab Bone Dis Rel Res, 5, 69, 10.1016/0221-8747(83)90004-8

Melsen, 1978, Tetracycline double-labeling of iliac trabecular bone in 41 normal adults, Calc Tiss Res, 26, 99, 10.1007/BF02013242

Whyte, 1982, Postmenopausal osteoporosis: a heterogeneous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients, Am J Med, 72, 193, 10.1016/0002-9343(82)90810-5

Meunier, 1981, Osteoporosis: Recent Advances in Pathogenesis and Treatment, 293

Meunier, 1979, Osteoporosis II, 27

Eriksen, 1985, Effect of sodium fluoride, calcium, phosphate, and vitamin D2 on trabecular bone balance and remodeling in osteoporotics, Bone, 6, 381, 10.1016/8756-3282(85)90337-0

Bressot, Histomorphometric profile, pathophysiology and reversibility of corticosteroid-induced osteoporosis, Metab Bone Dis Rel Res, 1, 303, 10.1016/0221-8747(79)90024-9

Meunier, 1981, Osteoporosis: Recent Advances in Pathogenesis and Treatment, 449

Parsons, 1981, Osteoporosis: Recent Advances in Pathogenesis and Treatment, 457

Delmas, 1982, Long-term effect of dichloromethylene diphosphonate on skeletal lesions in multiple myeloma, Metab Bone Dis Rel Res, 4, 163, 10.1016/0221-8747(82)90013-3

Delmas, 1984, Osteoporosis I, 581

Lane, 1984, Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry, Orth Clin No Am, 15, 729, 10.1016/S0030-5898(20)31266-9

Treloar, 1981, Menstrual cyclicity and the pre-menopause, Maturitas, 3, 249, 10.1016/0378-5122(81)90032-3

Rao, 1983, Bone Histomorphometry: Techniques and Interpretation, 3

Baron, 1983, Bone Histomorphometry: Techniques and Interpretation, 13

Goldner, 1938, A modification of the Masson trichrome technique for routine laboratory purposes, Am J Pathol, 14, 237

Keshawarz, 1984, Expansion of the medullary cavity at the expense of cortex in postmenopausal osteoporosis, Metab Bone Dis Rel Res, 5, 233, 10.1016/0221-8747(84)90063-8

Merz, 1967, Die Streckenmessung an gerichteten Strukturen in Mikroskop und ihre Anwendung zur Bestimmung von Oberflachen-Volumen-Relationen im Knochengewebe, Mikroscopie, 22, 132

Kimmel, 1983, Bone Histomorphometry: Techniques and Interpretation, 89

Kragstrup, 1983, Thickness of bone formed at remodeling sites in normal human iliac trabecular bone: variations with age and sex, Metab Bone Dis Rel Res, 5, 17, 10.1016/0221-8747(83)90046-2

Frost, 1983, Bone Histomorphometry: Techniques and Interpretation, 109

Parfitt, 1987, Histomorphometry: standardization of nomenclature, symbols and units, J Bone Min Res, 2, 595, 10.1002/jbmr.5650020617

Parfitt, 1983, Relationships between surface, volume and thickness of iliac trabecular bone in aging and in osteoporosis, J Clin Inv, 72, 1396, 10.1172/JCI111096

Nie, 1975, SPSS

Sokal, 1969, 119

Taylor, 1966, The appositional rate of haversian and endosteal bone formation measured in tetracycline labeled human ribs, J Lab Clin Med, 67, 633

Chavassieux

Meunier, 1975, Vitamin D and Problems Related to Uremic Bone Disease, 149

Ettinger, 1985, Long-term estrogen replacement therapy prevents bone loss and fractures, Ann Int Med, 102, 319, 10.7326/0003-4819-102-3-319

Recker, 1977, Effects of estrogens and calcium carbonate on bone loss in postmenopausal women, Ann Intern Med, 87, 649, 10.7326/0003-4819-87-6-649

Christiansen, 1980, Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females, Eur J Clin Invest, 10, 273, 10.1111/j.1365-2362.1980.tb00033.x

Richelson, 1984, Relative contributions of aging and estrogen deficiency to postmenopausal bone loss, New Eng J Med, 311, 1273, 10.1056/NEJM198411153112002

Riis, 1986, The role of serum concentrations of sex steroids and bone turnover in the development and occurrence of postmenopausal osteoporosis, Calc Tiss Int, 38, 318, 10.1007/BF02555743

Dequeker, 1985, Contributions of aging and estrogen deficiency to postmenopausal bone loss, New Engl J Med, 313, 453, 10.1056/NEJM198508153130715

Thomsen, 1986, Is postmenopausal bone loss an age-related phenomenon?, Calc Tiss Int, 39, 123, 10.1007/BF02555106

Wronski, 1985, Skeletal alterations in ovariectomized rats, Calc Tiss Int, 37, 324, 10.1007/BF02554882

Jerome, 1986, Effects of ovariectomy on iliac trabecular bone in baboons (Papio anubis), Calc Tiss Int, 39, 206, 10.1007/BF02555119

Lips, 1978, Mean wall thickness of trabecular bone packets in the human iliac crest: changes with age, Calc Tiss Res, 26, 13, 10.1007/BF02013227

Courpron, 1981, Bone Histomorphometry III, 323

Eriksen, 1984, Reconstruction of the resorptive site in iliac trabecular bone: a kinetic model for bone resorption in 20 normal individuals, Bone, 5, 235

Kleerekoper, 1985, The role of three dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures, Calc Tiss Int, 37, 594, 10.1007/BF02554913

Uhthoff, 1986, Current Concepts of Bone Fragility, 10.1007/978-3-642-70709-4

Rao, 1983, Clinical Disorders of Bone and Mineral Metabolism, 224

Thông tin
Thông tin xuất bản

Oxford University Press (OUP)

Tập 3 Số 2

133-144

Thông tin tác giả