Santos, 2012, Design and production of sintered β-tricalcium phosphate 3D scaffolds for bone tissue regeneration, Mater Sci Eng C, 32, 1293, 10.1016/j.msec.2012.04.010
O'Brien, 2011, Biomaterials & scaffolds for tissue engineering, Mater Today, 14, 88, 10.1016/S1369-7021(11)70058-X
Wang, 2018, Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: a review, Eur J Pharm Biopharm, 127, 223, 10.1016/j.ejpb.2018.02.023
Basu, 2017
Langer, 1993, Tissue engineering, Science, 260, 920, 10.1126/science.8493529
Thavornyutikarn B, Chantarapanich N, Sitthiseripratip K, Thouas GA, Chen Q. Bone tissue engineering scaffolding: computer-aided scaffolding techniques, 2014;3(2–4).
Gu, 2012, Inkjet printed antibiotic- and calcium-eluting bioresorbable nanocomposite micropatterns for orthopedic implants, Acta Biomater, 8, 424, 10.1016/j.actbio.2011.08.006
Sapkal, 2016, Rapid prototyping assisted scaffold fabrication for bone tissue regeneration, J Mater Sci Res, 5, 79, 10.5539/jmsr.v5n4p79
Mourino, 2010, Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds, J R Soc Interface, 7, 209, 10.1098/rsif.2009.0379
Canale, 2008
Bikramjit, 2009
Butscher, 2011, Structural and material approaches to bone tissue engineering in powder-based three-dimensional printing, Acta Biomater, 7, 907, 10.1016/j.actbio.2010.09.039
Liu, 2006, Less harmful acidic degradation of poly(lactic-co-glycolic acid) bone tissue engineering scaffolds through titania nanoparticle addition, Int J Nanomed, 1, 541, 10.2147/nano.2006.1.4.541
O'Brien, 2011, Biomaterials and scaffolds for tissue engineering, Mater Today, 14, 32, 10.1016/S1369-7021(11)70058-X
Wieding, 2012, The effect of structural design on mechanical properties and cellular response of additive manufactured titanium scaffolds, Materials (Basel), 5, 1336, 10.3390/ma5081336
Caplan, 2000, Bone regeneration through cellular engg, 683
Basu, B. Ghosh, S. Indian Institute of Metals series Biomaterials for musculoskeletal regeneration applications, 2017.
Van Landuyt, 1995, The influence of high sintering temperatures on the mechanical properties of hydroxylapatite, J Mater Sci, Mater Med, 6, 8, 10.1007/BF00121239
Tancred, 1998, A synthetic bone implant macroscopically identical to cancellous bone, Biomaterials, 19, 2303, 10.1016/S0142-9612(98)00141-0
Wang, 2003, Developing bioactive composite materials for tissue replacement, Biomaterials, 24, 2133, 10.1016/S0142-9612(03)00037-1
Yuan, 2015, The preliminary performance study of the 3D printing of a tricalcium phosphate scaffold for the loading of sustained release anti-tuberculosis drugs, J Mater Sci, 50, 2138, 10.1007/s10853-014-8776-0
Martínez-Vázquez, 2015, Fabrication of novel Si-doped hydroxyapatite/gelatine scaffolds by rapid prototyping for drug delivery and bone regeneration, Acta Biomater, 15, 200, 10.1016/j.actbio.2014.12.021
Bose, 2013, Bone tissue engineering using 3D printing, Mater Today, 16, 496, 10.1016/j.mattod.2013.11.017
Liu, 2013, Review: Development of clinically relevant scaffolds for vascularised bone tissue engineering, Biotechnol Adv, 31, 688, 10.1016/j.biotechadv.2012.10.003
Babensee, 1998, Host response to tissue engineered devices, Adv Drug Deliv Rev, 33, 111, 10.1016/S0169-409X(98)00023-4
Ueng, 2000, Biodegradable alginate antibiotic beads, Clin Orthop Relat Res, 380, 250, 10.1097/00003086-200011000-00034
Yeong, 2004, Rapid prototyping in tissue engineering: challenges and potential, Trends Biotechnol, 22, 643, 10.1016/j.tibtech.2004.10.004
Sapkal, 2016, Indirect fabrication of hydroxyapatite/β-tricalcium phosphate scaffold for osseous tissue formation using additive manufacturing technology, J Porous Mater, 23, 1567, 10.1007/s10934-016-0217-9
Makarov, 2014, In vitro elution of vancomycin from biodegradable osteoconductive calcium phosphate-polycaprolactone composite beads for treatment of osteomyelitis, Eur Rev Med Pharmacol Sci, 62, 49, 10.1016/j.ejps.2014.05.008
Ginebra, 2006, Calcium phosphate cements as bone drug delivery systems: a review, J Control Release, 113, 102, 10.1016/j.jconrel.2006.04.007
Liebschner, 2003, Optimization of bone scaffold engineering for load bearing applications, Top Tissue Eng, 1
Domingo-Espin, 2015, Mechanical property characterization and simulation of fused deposition modeling Polycarbonate parts, Mater Des, 83, 670, 10.1016/j.matdes.2015.06.074
Wang, 2016, A novel approach to improve mechanical properties of parts fabricated by fused deposition modeling, Mater Des, 105, 152, 10.1016/j.matdes.2016.05.078
Kaveh, 2015, Optimization of the printing parameters affecting dimensional accuracy and internal cavity for HIPS material used in fused deposition modeling processes, J Mater Process Technol, 226, 280, 10.1016/j.jmatprotec.2015.07.012
Karageorgiou, 2005, Porosity of 3D biomaterial scaffolds and osteogenesis, Biomaterials, 26, 5474, 10.1016/j.biomaterials.2005.02.002
Hollister, 2005, Porous scaffold design for tissue engineering, Nat Mater, 4, 518, 10.1038/nmat1421
Ahearne, 2008, Mechanical characterisation of hydrogels for tissue engineering applications, Tissue Eng, 4, 1
Sapkal, 2016, Rapid prototyping assisted fabrication of patient specific β-tricalciumphosphate scaffolds for bone tissue regeneration, J Porous Mater, 23, 927, 10.1007/s10934-016-0150-y
Temenoff, 2000, Injectable biodegradable materials for orthopedic tissue engineering, Biomaterials, 21, 2405, 10.1016/S0142-9612(00)00108-3
Chia, 2015, Recent advances in 3D printing of biomaterials, J Biol Eng, 9, 4, 10.1186/s13036-015-0001-4
Leukers, 2005, Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing, J Mater, 6, 1121
Stoppato, 2013, Influence of scaffold pore size on collagen I development: a new in vitro evaluation perspective, J Bioact Compat Polym, 28, 16, 10.1177/0883911512470885
Guan, 2004, Preparation and characterization of a highly macroporous biodegradable composite tissue engineering scaffold, J Biomed Mater Res, Part A, 71, 480, 10.1002/jbm.a.30173
Nemati Hayati, 2011, Preparation of poly(3-hydroxybutyrate)/nano-hydroxyapatite composite scaffolds for bone tissue engineering, Mater Lett, 65, 736, 10.1016/j.matlet.2010.11.004
Puppi, 2010, Polymeric materials for bone and cartilage repair, Prog Polym Sci, 35, 403, 10.1016/j.progpolymsci.2010.01.006
Morsi, 2008, Virtual Prototyping of Biomanufacturing in Medical Applications, Virtual Prototyp. Bio-manufacturing Med. Appl., 129, 10.1007/978-0-387-68831-2_7
Harris, 1998, Open pore biodegradable matrices formed with gas foaming, J Biomed Mater Res, 42, 396, 10.1002/(SICI)1097-4636(19981205)42:3<396::AID-JBM7>3.0.CO;2-E
Chen, 2011, Foaming technology of tissue engineering scaffolds - a review, Bubble Sci Eng Technol, 3, 34, 10.1179/1758897911Y.0000000003
Cao, 2010, A biodegradable porous composite scaffold of PGA/β-TCP for bone tissue engineering, Bone, 46, 386, 10.1016/j.bone.2009.09.031
Roseti, 2017, Scaffolds for bone tissue engineering: state of the art and new perspectives, Mater Sci Eng C, 78, 1246, 10.1016/j.msec.2017.05.017
Mooney, 1996, Novel approach to fabricate porous sponges of poly (l,d-lactic-co-glycolic acid) without the use of organic solvents, Biomaterials, 17, 1417, 10.1016/0142-9612(96)87284-X
Grimm, 2004
Leong, 2003, Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs, Biomaterials, 24, 2363, 10.1016/S0142-9612(03)00030-9
Pham, 2006, Electrospinning of polymeric nanofibers for tissue engineering applications: a review, Tissue Eng, 12, 1197, 10.1089/ten.2006.12.1197
Grimm T. Prototyping.
Crouch, 2009, Correlation of anisotropic cell behaviors with topographic aspect ratio, Biomaterials, 30, 1560, 10.1016/j.biomaterials.2008.11.041
Chua, 2011, Selective laser sintering of functionally graded tissue scaffolds, Mater Res Soc Bull, 36, 1006, 10.1557/mrs.2011.271
Hutmacher, 2004, Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems, Trends Biotechnol, 22, 354, 10.1016/j.tibtech.2004.05.005
Jammalamadaka, 2018, Recent advances in biomaterials for 3D printing and tissue engineering, J Funct Biomater, 9, 10.3390/jfb9010022
Wen, 2017, 3D printed porous ceramic scaffolds for bone tissue engineering: a review, Biomater Sci, 5, 1690, 10.1039/C7BM00315C
Peltola, 2008, A review of rapid prototyping techniques for tissue engineering purposes, Ann Med, 40, 268, 10.1080/07853890701881788
Park, 1998, Integration of surface modification and 3D fabrication technique to prepare patterned poly (L-lactide) substrates allowing regionally selective cell adhesion, J Biomater Sci, Polym Ed, 9, 89, 10.1163/156856298X00451
Hutmacher, 2001, Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling, J Biomed Mater Res, 55, 203, 10.1002/1097-4636(200105)55:2<203::AID-JBM1007>3.0.CO;2-7
Fisher, 2002, Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials, Biomaterials, 23, 4333, 10.1016/S0142-9612(02)00178-3
Minna, 2008, A review of rapid prototyping techniques for tissue engineering purposes, Ann Med, 40, 268, 10.1080/07853890701881788
Sapkal, 2016, Indirect casting of patient-specific tricalcium phosphate zirconia scaffolds for bone tissue regeneration using rapid prototyping methodology, J Porous Mater, 24, 1013, 10.1007/s10934-016-0341-6
Sachs, 1990, Three-dimensional printing: rapid tooling and prototypes directly form a CAD model, CIRP Ann, 39, 201, 10.1016/S0007-8506(07)61035-X
Warnke, 2010, Ceramic scaffolds produced by computer-assisted 3D printing and sintering: characterization and biocompatibility investigations, J Biomed Mater Res, Part B, Appl Biomater, 93, 212
Downes, 1989, Mechanism of antibiotic release from poly(methyl methacrylate) bone cement, Clin Mater, 4, 109, 10.1016/0267-6605(89)90002-4
Ferracini, 2018, Scaffolds as structural tools for bone-targeted drug delivery, Pharmaceutics, 10, 1, 10.3390/pharmaceutics10030122
Ambrose, 2004, Effective treatment of osteomyelitis with biodegradable microspheres in a rabbit model, Clin Orthop Relat Res, 421, 293, 10.1097/01.blo.0000126303.41711.a2
Liu, 2012, Steady antibiotic release from biodegradable beads in the pleural cavity: an in vitro and in vivo study, Chest, 141, 1197, 10.1378/chest.11-1254
Mader, 1993, Antimicrobial treatment of osteomyelitis, Clin Orthop Relat Res, 295, 87, 10.1097/00003086-199310000-00013
Dorati, 2017, Biodegradable scaffolds for bone regeneration combined with drug-delivery systems in osteomyelitis therapy, Pharmaceuticals, 10, 10.3390/ph10040096
Higuchi, 1963, Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices, J Pharm Sci, 52, 1145, 10.1002/jps.2600521210
Tung, 1995, In vitro drug release of antibiotic-loaded porous hydroxyapatite cement, Artif Cells, Blood Substitutes, Biotechnol, 23, 81, 10.3109/10731199509117669
Suzuki, 2002, Dissolution tests for self-setting calcium phosphate cement-containing nifedipine, Chem Pharm Bull (Tokyo), 50, 741, 10.1248/cpb.50.741
Joly, 1997, Survival, proliferation, and functions of porcine hepatocytes encapsulated in coated alginate beads: a step toward a reliable bioartificial liver, Transplantation, 63, 795, 10.1097/00007890-199703270-00002
Kendall, 1996, Persistence of bacteria on antibiotic loaded acrylic depots. A reason for caution, Clin Orthop Relat Res, 329, 273, 10.1097/00003086-199608000-00034
Kanellakopoulou K, et al. JAC Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system. 2000, pp. 311–314.
Jain, 2000, Skeletal drug delivery systems, Int J Pharm, 206, 1
Nelson, 2004, The current status of material used for depot delivery of drugs, Clin Orthop Relat Res, 427, 72, 10.1097/01.blo.0000143741.92384.18
Bayston, 1990, Production of extra-cellular slime by Staphylococcus epidermidis during stationary phase of growth: its association with adherence to implantable devices, J Clin Pathol, 43, 866, 10.1136/jcp.43.10.866
Ethell, 2000, In vitro elution of gentamicin, amikacin, and ceftiofur from polymethylmethacrylate and hydroxyapatite cement, Vet Surg, 29, 375, 10.1053/jvet.2000.7535
Otsuka, 1994, A novel skeletal drug-delivery system using self-setting calcium phosphate cement. 4. Effects of the mixing solution volume on the drug-release rate of heterogeneous aspirin-loaded cement, J Pharm Sci, 83, 259, 10.1002/jps.2600830230
Musson, 2013, The need for thorough in vitro testing of biomaterial scaffolds: two case studies, Proc Eng, 59, 138, 10.1016/j.proeng.2013.05.103
Monaco, 2015, Microstructural study of microwave sintered zirconia for dental applications, Ceram Int, 41, 1255, 10.1016/j.ceramint.2014.09.055
Ginebra, 2001, Mechanical and rheological improvement of a calcium phosphate cement by the addition of a polymeric drug, J Biomed Mater Res, 57, 113, 10.1002/1097-4636(200110)57:1<113::AID-JBM1149>3.0.CO;2-5
Kim, 2010, Polyoxalate nanoparticles as a biodegradable and biocompatible drug delivery vehicle, Biomacromolecules, 11, 555, 10.1021/bm901409k
Wang, 2004, The release of cefazolin and gentamicin from biodegradable PLA/PGA beads, Int J Pharm, 273, 203, 10.1016/j.ijpharm.2004.01.010
Ambrose, 2003, Antibiotic microspheres: preliminary testing for potential treatment of osteomyelitis, Clin Orthop Relat Res, 415, 279, 10.1097/01.blo.0000093920.26658.ae
Sugawara, 2013, Calcium phosphate-based cements: clinical needs and recent progress, J Mater Chem B, 1, 1081, 10.1039/C2TB00061J
Heijink, 2006, Local antibiotic delivery with OsteoSet, DBX, and Collagraft, Clin Orthop Relat Res, 451, 29, 10.1097/01.blo.0000229319.45416.81
Liu, 2005, A novel solvent-free method for the manufacture of biodegradable antibiotic-capsules for a long-term drug release using compression sintering and ultrasonic welding techniques, Biomaterials, 26, 4662, 10.1016/j.biomaterials.2004.11.053
Charlton-Ouw, 2015, In vitro efficacy of antibiotic beads in treating abdominal vascular graft infections, J Vasc Surg, 62, 1048, 10.1016/j.jvs.2014.03.241
Agarwal, 2014, ScienceDirect The use of antibiotic impregnated absorbable calcium sulphate beads in management of infected joint replacement prostheses, J Arthrosc Jt Surg, 1, 72, 10.1016/j.jajs.2014.06.005
Huttner, 2012, Beads vs bugs?, Chest, 141, 1136, 10.1378/chest.11-2637
Klemm, 2001, The use of antibiotic-containing bead chains in the treatment of chronic bone infections, Clin Microbiol Infect, 7, 28, 10.1046/j.1469-0691.2001.00186.x
Li, 2015, Three-dimensionally plotted MBG/PHBHHx composite scaffold for antitubercular drug delivery and tissue regeneration, J Mater Sci, Mater Med, 26, 10.1007/s10856-015-5455-x
Stigter, 2002, Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium, Biomaterials, 23, 4143, 10.1016/S0142-9612(02)00157-6
Zilberman, 2008, Antibiotic-eluting medical devices for various applications, J Control Release, 130, 202, 10.1016/j.jconrel.2008.05.020
Neut, 2009, A biodegradable antibiotic delivery system based on poly-(trimethylene carbonate) for the treatment of osteomyelitis, Acta Orthop, 80, 514, 10.3109/17453670903350040
Calhoun, 2005, Adult osteomyelitis, Infect Dis Clin North Am, 19, 765, 10.1016/j.idc.2005.07.009
Antonialli, 2011, Numerical evaluation of reduction of stress shielding in laser coated hip prostheses, Mater Res, 14, 331, 10.1590/S1516-14392011005000043
Heckman, 2008, Campbell's operative orthopaedics. 11th ed., J Bone Jt Surg, Am, 90, 943
Shirtliff, 2002, Experimental osteomyelitis treatment with antibiotic-impregnated hydroxyapatite, Clin Orthop Relat Res, 401, 239, 10.1097/00003086-200208000-00027
Kanellakopoulou, 2009, Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a synthetic carrier of calcium sulphate (Stimulan®) releasing moxifloxacin, Int J Antimicrob Agents, 33, 354, 10.1016/j.ijantimicag.2008.09.008
Anguita-Alonso, 2006, Comparative study of antimicrobial release kinetics from polymethylmethacrylate, Clin Orthop Relat Res, 445, 239, 10.1097/01.blo.0000201167.90313.40
Kalita, 2003, Development of controlled porosity polymer-ceramic composite scaffolds via fused deposition modeling, Mater Sci Eng C, 23, 611, 10.1016/S0928-4931(03)00052-3
Liu, 2013, Selective laser sintering of bio-metal scaffold, Procedia CIRP, 5, 83, 10.1016/j.procir.2013.01.017
Laine, 2011, Effects of mixing techniques on vancomycin-impregnated polymethylmethacrylate, J Arthroplast, 26, 1562, 10.1016/j.arth.2011.02.011
Buranapanitkit, 2004, The efficacy of a hydroxyapatite composite as a biodegradable antibiotic delivery system, Clin Orthop Relat Res, 424, 244, 10.1097/01.blo.0000130268.27024.c1
De Mori, 2018, 3D printing and electrospinning of composite hydrogels for cartilage and bone tissue engineering, Polymers (Basel), 10, 1, 10.3390/polym10030285
Niinomi, 2011, Titanium-based biomaterials for preventing stress shielding between implant devices and bone, Int J Biomater, 2011, 10.1155/2011/836587
Rezwan, 2006, Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering, Biomaterials, 27, 3413, 10.1016/j.biomaterials.2006.01.039
Mourino, 2010, Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds, J R Soc Interface, 7, 209, 10.1098/rsif.2009.0379
Chai, 2012, Current views on calcium phosphate osteogenicity and the translation into effective bone regeneration strategies, Acta Biomater, 8, 3876, 10.1016/j.actbio.2012.07.002
Dong, 2018, Three-dimensional printing of β-tricalcium phosphate/calcium silicate composite scaffolds for bone tissue engineering, Bio-Design Manuf, 1, 146, 10.1007/s42242-018-0010-5
García-Alvarez, 2017, 3D scaffold with effective multidrug sequential release against bacteria biofilm, Acta Biomater, 49, 113, 10.1016/j.actbio.2016.11.028
O'Brien, 2011, Biomaterials and scaffolds for tissue engineering, Mater Today, 14, 32, 10.1016/S1369-7021(11)70058-X
Place, 2009, Complexity in biomaterials for tissue engineering, Nat Mater, 8, 457, 10.1038/nmat2441