Squamous cell carcinoma with rhabdoid features of the gingiva: a case report with unusual histology

Medical Molecular Morphology - Tập 47 - Trang 240-245 - 2013
Kimihide Kusafuka1, Tetsuro Onitsuka2, Tomoko Miki1, Chika Murai3, Toshihito Suda2, Tomohito Fuke2, Tomoyuki Kamijo2, Yoshiyuki Iida2, Takashi Nakajima1
1Pathology Division, Shizuoka Cancer Center, Sunto-gun, Japan
2Division of Head and Neck Surgery, Shizuoka Cancer Center, Shizuoka, Japan
3Division of Dentistry and Oral Surgery, Shizuoka Cancer Center, Shizuoka, Japan

Tóm tắt

Squamous cell carcinoma (SCC) with rhabdoid features (SCCRF) is extremely rare in the oral cavity. We report herein a case of oral SCCRF. The patient was a 69-year-old Japanese woman who had been suffering from a mass in the right lower gingiva. Right hemi-mandibulectomy was performed. The gingival tumor was composed of pleomorphic, non-cohesive ovoid tumor cells with abundant cytoplasm and eccentric nuclei, which were positive for both pan-cytokeratin and vimentin. In another portion, moderately differentiated SCC and carcinoma in situ were also seen. A transition zone existed between the components. Finally, we diagnosed SCCRF. Four months after the operation, multiple bone metastases, lung and skin metastases and marked hypercalcemia were found. SCCRF, therefore, might be more aggressive than the usual type of oral SCC.

Tài liệu tham khảo

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