Spread of a Methicillin-Resistant Staphylococcus aureus ST80-IV Clone in a Danish Community

Infection Control and Hospital Epidemiology - Tập 26 Số 2 - Trang 144-149 - 2005
Tinna Ravnholt Urth1, Gitte Juul1, Robert Skov2, Henrik Carl Schønheyder3,1
1Department of Clinical Microbiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
2National Center for Antimicrobials and Infection Control, Statens Serum Institut, Copenhagen, Denmark
3Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

Tóm tắt

AbstractObjective:We report a community cluster of methicillin-resistant Staphylococcus aureus (MRSA) in Denmark with emphasis on routes of transmission and infection control measures. The objective is to extend knowledge of MRSA in a community setting where a nosocomial link could effectively be ruled out.Design:Population-based observational study from November 1997 until June 2003.Setting:North Jutland County, with approximately 495,000 inhabitants.Subjects:The cluster encompassed 46 individuals and 26 households.Interventions:Infection control measures included repeated visits to affected households by an infection control nurse who undertook screening for carriage among all household members and provided a program for decolonization.Results:The causal strain was identical to a newly described international clone, ST80; SSCmec type IV; and Panton–Valentine leukocidin positive. Plausible routes of transmission included household contact and contact at work, kindergarten, and school. We did not detect a nosocomial source or any secondary cases in hospitals. Transmission by healthcare contact outside the hospital was plausible for three cases. We found evidence that the clone was introduced on more than one occasion to immigrant families from the Middle East. A 5-day decolonization program was successful at first attempt in 15 of 16 households that could be evaluated.Conclusions:Despite the described infection control measures, we continued to see new cases, underlining a need for a national policy to contain MRSA in the community.

Từ khóa


Tài liệu tham khảo

2003, Use of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Bacteria From Food Animals, Foods and Humans in Denmark

10.1086/345436

10.1097/00001432-200304000-00007

10.1128/JCM.41.5.2027-2032.2003

10.1086/517478

10.1001/jama.279.8.593

10.1001/jama.282.11.1038

Skov R , Eisberg CS , Moller JK , Gahrn-Hansen B , Schenheyder HC , Westh H . Dissemination of a MRSA clone in Denmark. Presented at the 9th International Symposium on Staphylococci and Staphylococcal Infections; June 14-17, 2000; Kolding, Denmark. Abstract 221.

10.1086/502221

10.1097/00006454-200105000-00023

10.1086/502225

10.3201/eid0801.010174

10.1086/502228

10.2307/30147049

Faria NA , Oliveira DC , Westh H , et al. Epidemiology of emerging methicillin-resistant Staphylococcus aureus in Denmark: a nationwide study in a low prevalence country. J Clin Microbiol. In press.

10.1111/j.1699-0463.1994.tb04891.x

Witte, 2004, Emergence of a new community acquired MRSA strain in Germany, Euro Surveillance, 9, 1

Zimakoff, 1989, Supplementary treatment of recurrent familial furunculosis [in Danish], Maanedsskrifl for Praktisk Laegegerning, 67, 343

10.1001/archinte.1994.00420130101013

10.1007/BF02026130

10.1086/342196

10.1001/archinte.158.8.895

Rosdahl, 1994, Staphylococcus aureus: 33-year epidemiology in Denmark. From hospital epidemics to endogenous infections [in Danish]?, Ugeskr Laeger, 156, 2057

Thông tin
Thông tin xuất bản

Infection Control and Hospital Epidemiology

Tập 26 Số 2

144-149

Thông tin tác giả