Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function

Rigg, 1996, Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node, Exp. Physiol., 81, 877, 10.1113/expphysiol.1996.sp003983 Li, 1997, Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node, Am. J. Physiol., 273, H2481 Bogdanov, 2001, Sinoatrial nodal cell ryanodine receptor and Na+–Ca2+ exchanger: molecular partners in pacemaker regulation, Circ. Res., 88, 1254, 10.1161/hh1201.092095 Sanders, 2006, Fundamental importance of Na+–Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node, J. Physiol., 571, 639, 10.1113/jphysiol.2005.100305 Vinogradova, 2002, beta-Adrenergic stimulation modulates ryanodine receptor Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells, Circ. Res., 90, 73, 10.1161/hh0102.102271 Lakatta, 2002, Beta-adrenergic stimulation modulation of heart rate via synchronization of ryanodine receptor Ca2+ release, J. Card. Surg., 17, 451, 10.1111/j.1540-8191.2001.tb01177.x Vinogradova, 2004, Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization, Circ. Res., 94, 802, 10.1161/01.RES.0000122045.55331.0F Maltsev, 2004, Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process, Biophys. J., 86, 2596, 10.1016/S0006-3495(04)74314-3 Ju, 2001, Does Ca2+ release from the sarcoplasmic reticulum influence heart rate?, Clin. Exp. Pharmacol. Physiol., 28, 703, 10.1046/j.1440-1681.2001.03506.x Zhou, 1993, Na+–Ca2+ exchange current in latent pacemaker cells isolated from cat right atrium, J. Physiol., 466, 263 Huser, 2000, Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells, J. Physiol., 524, 415, 10.1111/j.1469-7793.2000.00415.x Convery, 2000, Na+–Ca2+ exchange current from rabbit isolated atrioventricular nodal and ventricular myocytes compared using action potential and ramp waveforms, Acta Physiol. Scand., 168, 393, 10.1046/j.1365-201x.2000.00681.x Hancox, 1994, Intracellular calcium transients recorded with Fura-2 in spontaneously active myocytes isolated from the atrioventricular node of the rabbit heart, Proc. Biol. Sci., 255, 99, 10.1098/rspb.1994.0014 Nikmaram, 2007, Characterization of the effects of Ryanodine, TTX, E-4031 and 4-AP on the sinoatrial and atrioventricular nodes, Prog. Biophys. Mol. Biol., 96, 452, 10.1016/j.pbiomolbio.2007.07.003 Meijler, 1988, Morphology and electrophysiology of the mammalian atrioventricular node, Physiol. Rev., 68, 608, 10.1152/physrev.1988.68.2.608 Hancox, 1993, A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function, Am. J. Physiol., 265, H755 Hancox, 1994, The hyperpolarisation-activated current, If, is not required for pacemaking in single cells from the rabbit atrioventricular node, Pflugers Arch., 427, 121, 10.1007/BF00585950 Howarth, 1996, Characteristics of the delayed rectifier K current compared in myocytes isolated from the atrioventricular node and ventricle of the rabbit heart, Pflugers Arch., 431, 713, 10.1007/BF02253834 Isenberg, 1982, Calcium tolerant ventricular myocytes prepared by preincubation in a “KB medium”, Pflugers Arch., 395, 6, 10.1007/BF00584963 Nisbet, 2007, Acidosis delays conduction through the atrioventricular node (abstract), PC12 Brette, 2005, Spatiotemporal characteristics of SR Ca2+ uptake and release in detubulated rat ventricular myocytes, J. Mol. Cell Cardiol., 39, 804, 10.1016/j.yjmcc.2005.08.005 Cheng, 1999, Amplitude distribution of calcium sparks in confocal images: theory and studies with an automatic detection method, Biophys. J., 76, 606, 10.1016/S0006-3495(99)77229-2 Levi, 1996, A method for making rapid changes of superfusate whilst maintaining temperature at 37°C, Pflugers Arch., 432, 930, 10.1007/s004240050217 Leach, 2005, Effect of cytoskeleton disruptors on L-type Ca channel distribution in rat ventricular myocytes, Cell Calcium, 38, 515, 10.1016/j.ceca.2005.07.006 Rigg, 2000, Localisation and functional significance of ryanodine receptors during beta-adrenoceptor stimulation in the guinea-pig sino-atrial node, Cardiovasc. Res., 48, 254, 10.1016/S0008-6363(00)00153-X Wilders, 1993, Beating irregularity of single pacemaker cells isolated from the rabbit sinoatrial node, Biophys. J., 65, 2601, 10.1016/S0006-3495(93)81289-X Hancox, 2003, Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node, Int. J. Bifurcation Chaos, 13, 3675, 10.1142/S021812740300879X Marino, 1979, The atrioventricular node and bundle in the ferret heart: a light and quantitative electron microscopic study, Am. J. Anat., 154, 365, 10.1002/aja.1001540305 Brette, 2003, T-tubule function in mammalian cardiac myocytes, Circ. Res., 92, 1182, 10.1161/01.RES.0000074908.17214.FD Shannon, 2000, Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes, Biophys. J., 78, 322, 10.1016/S0006-3495(00)76595-7 Shattock, 1989, Rat vs. rabbit ventricle: Ca flux and intracellular Na assessed by ion-selective microelectrodes, Am. J. Physiol., 256, C813, 10.1152/ajpcell.1989.256.4.C813 Matthes, 2004, Disturbed atrio-ventricular conduction and normal contractile function in isolated hearts from Cav1.3-knockout mice, Naunyn Schmiedebergs Arch. Pharmacol., 369, 554, 10.1007/s00210-004-0940-7 Ho, 1994, High selectivity of the If channel to Na+ and K+ in rabbit isolated sinoatrial node cells, Pflugers Arch., 426, 68, 10.1007/BF00374672 Nakayama, 1984, Action potential and membrane currents of single pacemaker cells of the rabbit heart, Pflugers Arch., 402, 248, 10.1007/BF00585507 Hagiwara, 1992, Background current in sino-atrial node cells of the rabbit heart, J. Physiol., 448, 53, 10.1113/jphysiol.1992.sp019029 Kang, 2004, Multiple transport modes of the cardiac Na+/Ca2+ exchanger, Nature, 427, 544, 10.1038/nature02271 Ju, 2007, Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node, Circ. Res., 100, 1605, 10.1161/CIRCRESAHA.107.152181