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Biểu hiện tự phát ở bệnh nhân nhồi máu cơ tim ST đoạn chênh tạm thời—Tỷ lệ, tầm quan trọng và phương pháp quản lý
Tóm tắt
Bệnh nhân mắc nhồi máu cơ tim ST đoạn chênh tạm thời (STEMI) hoặc tự phát hồi phục (SpR) của đoạn ST trên điện tâm đồ có thể đại diện cho một nhóm bệnh nhân đặc biệt, gây ra những khó khăn trong quản lý điều trị. Trong bài tổng quan này, chúng tôi thảo luận về các cơ chế tiềm năng liên quan đến SpR, mối quan hệ của nó với các kết quả lâm sàng và các tùy chọn quản lý đề xuất cho bệnh nhân mắc STEMI tạm thời, chú trọng vào can thiệp động mạch vành qua da ngay lập tức so với sớm. Chúng tôi đã thực hiện một tìm kiếm tài liệu có cấu trúc từ cơ sở dữ liệu PubMed và Thư viện Cochrane từ khi thành lập đến tháng 12 năm 2020. Các nghiên cứu tập trung vào SpR ở bệnh nhân mắc hội chứng động mạch vành cấp tính đã được chọn. Dữ liệu hiện có cho thấy việc hoãn chụp động mạch và phục hồi trong vòng 24–48 giờ ở những bệnh nhân này là hợp lý và liên quan đến kết quả tương tự hoặc có thể tốt hơn so với chụp động mạch ngay lập tức. Cần có thêm các thử nghiệm ngẫu nhiên để làm sáng tỏ các chiến lược dược lý và xâm lấn tốt nhất cho nhóm bệnh nhân này.
Từ khóa
#nhồi máu cơ tim ST đoạn chênh tạm thời #hồi phục tự phát #can thiệp động mạch vành qua da #hội chứng động mạch vành cấp tínhTài liệu tham khảo
Bainey KR, Fu Y, Wagner GS, et al. Spontaneous reperfusion in ST-elevation myocardial infarction: comparison of angiographic and electrocardiographic assessments. Am Heart J. 2008;156:248–55.
Bellandi B, Zocchi C, Xanthopoulou I, et al. Morphine use and myocardial reperfusion in patients with acute myocardial infarction treated with primary PCI. Int J Cardiol. 2016;221:567–71.
Rentoukas I, Giannopoulos G, Kaoukis A, et al. Cardioprotective role of remote ischemic periconditioning in primary percutaneous coronary intervention. JACC Cardiovasc Interv. 2010;3:49–55.
Schröder R, Dissmann R, Brüggemann T, et al. Extent of early ST segment elevation resolution: a simple but strong predictor of outcome in patients with acute myocardial infarction. J Am Coll Cardiol. 1994;24:384–91.
Rouleau F, Asfar P, Boulet S, et al. Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome. J Cardiovasc Electrophysiol. 2001;12:61–5.
Yasue H, Mizuno Y, Harada E. Coronary artery spasm-clinical features, pathogenesis and treatment. Proc Jpn Acad Ser B Phys Biol Sci. 2019;95:53–66.
Zelinger AB, Falk RH, Hood WB. Electrical-induced sustained myocardial depolarization as a possible cause for transient ST elevation post-DC elective cardioversion. Am Heart J. 1982;103:1073–4.
Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155:408–17.
Golzar J, Mustafa SJ, Movahed A. Chest pain and ST-segment elevation 3 minutes after completion of adenosine pharmacologic stress testing. J Nucl Cardiol. 2004;11:744–6.
Birnbaum Y, Fiol M, Nikus K, et al. A counterpoint paper: Comments on the electrocardiographic part of the 2018 Fourth Universal Definition of Myocardial Infarction. J Electrocardiol. 2020;60:142–7.
Rimar D, Crystal E, Battler A, et al. Improved prognosis of patients presenting with clinical markers of spontaneous reperfusion during acute myocardial infarction. Heart. 2002;88:352–6.
DeWood MA, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980;303:897–902.
Fefer P, Hod H, Hammerman H, Boyko V, Behar S, Matetzky S. Relation of clinically defined spontaneous reperfusion to outcome in ST-elevation myocardial infarction. Am J Cardiol. 2009;103:149–53.
Farag M, Spinthakis N, Gue YX, et al. Impaired endogenous fibrinolysis in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention is a predictor of recurrent cardiovascular events: the RISK PPCI study. Eur Heart J. 2019;40:295–305.
Blondheim DS, Kleiner-Shochat M, Asif A, et al. Characteristics, management, and outcome of transient ST-elevation versus persistent ST-elevation and non–ST-elevation myocardial infarction. Am J Cardiol. 2018;121:1449–55.
Meisel SR, Dagan Y, Blondheim DS, et al. Transient ST-elevation myocardial infarction: clinical course with intense medical therapy and early invasive approach, and comparison with persistent ST-elevation myocardial infarction. Am Heart J. 2008;155:848–54.
Badings EA, Remkes WS, The SHK, et al. Early or late intervention in patients with transient ST-segment elevation acute coronary syndrome: subgroup analysis of the ELISA-3 trial. Catheter Cardiovasc Interv. 2016;88:755–64.
Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 2018;39:119–77.
O’Gara PT, Kushner FG, Ascheim DD, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127:e362–425.
Collet J-P, Thiele H, Barbato E, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2021;42:1289–367.
Amsterdam EA, Wenger NK, Brindis RG, et al. 2014 AHA/ACC guideline for the management of patients with non-st-elevation acute coronary syndromes: a report of the American college of cardiology/American heart association task force on practice guidelines. Circulation. 2014;130:e344–426.
Lemkes JS, Janssens GN, van der Hoeven NW, et al. Timing of revascularization in patients with transient ST-segment elevation myocardial infarction: a randomized clinical trial. Eur Heart J. 2019;40:283–91.
Shavadia JS, Granger CB, Alemayehu W, et al. High-throughput targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction. Am Heart J. 2020;220:137–44.
Terkelsen CJ, Nørgaard BL, Lassen JF, et al. Potential significance of spontaneous and interventional ST-changes in patients transferred for primary percutaneous coronary intervention: observations from the ST-MONitoring in Acute Myocardial Infarction study (The MONAMI study). Eur Heart J. 2006;27:267–75.
Hashimoto T, Ako J, Nakao K, et al. Pre-procedural thrombolysis in myocardial infarction flow in patients with ST-segment elevation myocardial infarction a j-minuet substudy. Int Heart J. 2018;59:920–5.
Stone GW, Cox D, Garcia E, et al. Normal flow (TIMI-3) before mechanical reperfusion therapy is an independent determinant of survival in acute myocardial infarction: analysis from the Primary Angioplasty in Myocardial Infarction Trials. Circulation. 2001;104:636–41.
Steg PG, Himbert D, Benamer H, et al. Conservative management of patients with acute myocardial infarction and spontaneous acute patency of the infarct-related artery. Am Heart J. 1997;134:248–52.
Lee CW, Hong MK, Lee JH, et al. Determinants and prognostic significance of spontaneous coronary recanalization in acute myocardial infarction. Am J Cardiol. 2001;87:951–4.
Brener SJ, Mehran R, Brodie BR, et al. Predictors and implications of coronary infarct artery patency at initial angiography in patients with acute myocardial infarction (from the CADILLAC and HORIZONS-AMI Trials). Am J Cardiol. 2011;108:918–23.
Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317–25.
Gomez D, Owens G. Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc Res. 2012;95:156–64.
Falk E, Nakano M, Bentzon JF, Finn AV, Virmani R. Update on acute coronary syndromes: the pathologists’ view. Eur Heart J. 2013;34:719–28.
Falk E. Coronary thrombosis: pathogenesis and clinical manifestations. Am J Cardiol. 1991;68:28B-35B.
Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol. 2010;55:1147–58.
Falk E. Dynamics in thrombus formation. Ann N Y Acad Sci. 1992;667:204–23.
Ruggeri ZM. Platelets in atherothrombosis. Nat Med. 2002;8:1227–34.
Verouden NJ, Kramer MC, Li X, et al. Histopathology of aspirated thrombus and its association with ST-segment recovery in patients undergoing primary percutaneous coronary intervention with routine thrombus aspiration. Catheter Cardiovasc Interv. 2011;77:35–42.
Kramer MC, van der Wal AC, Koch KT, et al. Histopathological features of aspirated thrombi after primary percutaneous coronary intervention in patients with ST-Elevation myocardial infarction. PLoS One. 2009;4:2–7.
Sumaya W, Wallentin L, James SK, et al. Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy. Eur Heart J. 2018;39:1078–85.
Alam SR, Newby DE, Henriksen PA. Role of the endogenous elastase inhibitor, elafin, in cardiovascular injury: from epithelium to endothelium. Biochem Pharmacol. 2012;83:695–704.
Rijken DC, Lijnen HR. New insights into the molecular mechanisms of the fibrinolytic system. J Thromb Haemost. 2009;7:4–13.
Drew BJ, Pelter MM, Adams MG. Frequency, characteristics, and clinical significance of transient ST segment elevation in patients with acute coronary syndromes. Eur Heart J. 2002;23:941–7.
Arroyo Úcar E, Domínguez-Rodríguez A, Juárez Prera R, et al. Differential characteristics of patients with acute coronary syndrome without ST-segment elevation compared to those with transient ST-segment elevation. Med intensiva. 2011;35:270–3.
Patel JH, Gupta R, Roe MT, Peng SA, Wiviott SD, Saucedo JF. Influence of presenting electrocardiographic findings on the treatment and outcomes of patients with non-ST-segment elevation myocardial infarction. Am J Cardiol. 2014;113:256–61.
Ownbey M, Suffoletto B, Frisch A, Guyette FX, Martin-Gill C. Prevalence and interventional outcomes of patients with resolution of ST-segment elevation between prehospital and in-hospital ECG. Prehosp Emerg Care. 2014;18:174–9.
Leibowitz D, Gerganski P, Nowatzky J, Weiss AT, Rott D. Relation of spontaneous reperfusion in ST-elevation myocardial infarction to more distal coronary culprit narrowings. Am J Cardiol. 2008;101:308–10.
Sakariassen KS, Orning L, Turitto VT. The impact of bloosd shear rate on arterial thrombus formation. Futur Sci OA. 2015;1:FSO30.
Nesbitt WS, Westein E, Tovar-Lopez FJ, et al. A shear gradient-dependent platelet aggregation mechanism drives thrombus formation. Nat Med. 2009;15:665–73.
Gorog DA. Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications. J Thromb Thrombolysis. 2018;45:593–602.
Savage B, Almus-Jacobs F, Ruggeri ZM. Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell. 1998;94:657–66.
Huang P, Hellums J. Aggregation and disaggregation kinetics of human blood platelets: part II Shear-induced platelet aggregation. Biophys J. 1993;65:344–53.
Shi X, Yang J, Huang J, et al. Effects of different shear rates on the attachment and detachment of platelet thrombi. Mol Med Rep. 2016;13:2447–56.
Gorog D, Fayad Z, Fuster V. Arterial thrombus stability: does it matter and can we detect it? J Am Coll Cardiol. 2017;70:2036–47.
Li M, Hotaling N, Ku D, Forest C. Microfluidic thrombosis under multiple shear rates and antiplatelet therapy doses. PLoS One. 2014;9:e82493.
Basmadjian D. Embolization: critical thrombus height, shear rates, and pulsatility. patency of blood vessels. J Biomed Mater Res. 1989;23:1315–26.
Rich J, Cannon C, Murphy S, Qin J, Giugliano R, Braunwald E. Prior aspirin use and outcomes in acute coronary syndromes. J Am Coll Cardiol. 2010;56:1376–85.
Yonetsu T, Lee T, Murai T, et al. Association between prior aspirin use and morphological features of culprit lesions at first presentation of acute coronary syndrome assessed by optical coherence tomography. Circ J. 2017;81:511–9.
Zeymer U, Mochmann H-C, Mark B, et al. Double-blind, randomized, prospective comparison of loading doses of 600 mg clopidogrel versus 60 mg prasugrel in patients with acute ST-segment elevation myocardial infarction scheduled for primary percutaneous intervention. JACC Cardiovasc Interv. 2015;8:147–54.
Bailleul C, Puymirat E, Aissaoui N, et al. Factors associated with infarct-related artery patency before primary percutaneous coronary intervention for ST-elevation myocardial infarction (from the FAST-MI 2010 Registry). Am J Cardiol. 2016;117:17–21.
Montalescot G, Barragan P, Wittenberg O, et al. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med. 2001;344:1895–903.
Montalescot G, Borentain M, Payot L, Collet JP, Thomas D. Early vs late administration of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction a meta-analysis. JAMA. 2004;292:362–6.
Gyöngyösi M, Domanovits H, Benzer W, et al. Use of abciximab prior to primary angioplasty in STEMI results in early recanalization of the infarct-related artery and improved myocardial tissue reperfusion - results of the Austrian multi-centre randomized ReoPro-BRIDGING Study. Eur Heart J. 2004;25:2125–33.
Maioli M, Bellandi F, Leoncini M, Toso A, Dabizzi RP. Randomized early versus late abciximab in acute myocardial infarction treated with primary coronary intervention (RELAx-AMI Trial). J Am Coll Cardiol. 2007;49:1517–24.
Gödicke J, Flather M, Noc M, et al. Early versus periprocedural administration of abciximab for primary angioplasty: a pooled analysis of 6 studies. Am Heart J. 2005;150:1015.
Ellis SG, Tendera M, de Belder MA, et al. Facilitated PCI in patients with ST-elevation myocardial infarction. N Engl J Med. 2008;358:2205–17.
Heestermans T, van’t Hof A, ten Berg JM, et al. The golden hour of prehospital reperfusion with triple antiplatelet therapy: a sub-analysis from the Ongoing Tirofiban in Myocardial Evaluation 2 (On-TIME 2) trial early initiation of triple antiplatelet therapy. Am Heart J. 2010;160:1079–84.
Van’t Hof AWJ, Ten Berg J, Heestermans T, et al. Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial. Lancet. 2008;372:537–46.
De Luca G, Ucci G, Cassetti E, Marino P. Benefits from small molecule administration as compared with abciximab among patients with ST-segment elevation myocardial infarction treated with primary angioplasty: a meta-analysis. J Am Coll Cardiol. 2009;53:1668–73.
Zijlstra F, Ernst N, De Boer MJ, et al. Influence of prehospital administration of aspirin and heparin on initial patency of the infarct-related artery in patients with acute ST elevation myocardial infarction. J Am Coll Cardiol. 2002;39:1733–7.
Chung WY, Han MJ, Cho YS, et al. Effects of the early administration of heparin in patients with ST-elevation myocardial infarction treated by primary angioplasty. Circ J. 2007;71:862–7.
Giralt T, Carrillo X, Rodriguez-Leor O, et al. Time-dependent effects of unfractionated heparin in patients with ST-elevation myocardial infarction transferred for primary angioplasty. Int J Cardiol. 2015;198:70–4.
Karlsson S, Andell P, Mohammad MA, Koul S, Olivecrona GK, James SK, Fröbert O, Erlinge D. Editor’s Choice- Heparin pre-treatment in patients with ST-segment elevation myocardial infarction and the risk of intracoronary thrombus and total vessel occlusion. Insights from the TASTE trial. Eur Heart J Acute Cardiovasc Care. 2019;8:15–23.
Sejersten M, Nielsen SL, Engstrøm T, Jørgensen E, Clemmensen P. Feasibility and safety of prehospital administration of bivalirudin in patients with ST-elevation myocardial infarction. Am J Cardiol. 2009;103:1635–40.
Kubica J, Adamski P, Ostrowska M, et al. Morphine delays and attenuates ticagrelor exposure and action in patients with myocardial infarction: the randomized, double-blind, placebo-controlled IMPRESSION trial. Eur Heart J. 2016;37:245–52.
Silvain J, Storey RF, Cayla G, et al. P2Y12 receptor inhibition and effect of morphine in patients undergoing primary PCI for ST-segment elevation myocardial infarction. Thromb Haemost. 2016;116:369–78.
Montalescot G, Van’t Hof AW, Lapostolle F, et al. Prehospital ticagrelor in ST-segment elevation myocardial infarction. N Engl J Med. 2014;371:1016–27.
de Waha S, Eitel I, Desch S, et al. Intravenous morphine administration and reperfusion success in ST-elevation myocardial infarction: insights from cardiac magnetic resonance imaging. Clin Res Cardiol. 2015;104:727–34.
Farag M, Spinthakis N, Srinivasan M, Sullivan K, Wellsted D, Gorog D. Morphine analgesia pre-PPCI is associated with prothrombotic state, reduced spontaneous reperfusion and greater infarct size. Thromb Haemost. 2018;118:601–12.
Fefer P, Beigel R, Atar S, et al. Outcomes of patients presenting with clinical indices of spontaneous reperfusion in ST-elevation acute coronary syndrome undergoing deferred angiography. J Am Heart Assoc. 2017;6:e004552.
Uriel N, Moravsky G, Blatt A, et al. Acute myocardial infarction with spontaneous reperfusion: clinical characteristics and optimal timing for revascularization. Isr Med Assoc J. 2007;9:243–6.
Meneveau N, Séronde MF, Descotes-Genon V, et al. Immediate versus delayed angioplasty in infarct-related arteries with TIMI III flow and ST segment recovery: a matched comparison in acute myocardial infarction patients. Clin Res Cardiol. 2009;98:257–64.
Janssens GN, van der Hoeven NW, Lemkes JS, et al. 1-year outcomes of delayed versus immediate intervention in patients with transient ST-segment elevation myocardial infarction. JACC Cardiovasc Interv. 2019;12:2272–82.
Christian TF, Milavetz JJ, Miller TD, Clements IP, Holmes DR, Gibbons RJ. Prevalence of spontaneous reperfusion and associated myocardial salvage in patients with acute myocardial infarction. Am Heart J. 1998;135:421–7.
Ross AM, Coyne KS, Reiner JS, et al. A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: The PACT trial. J Am Coll Cardiol. 1999;34:1954–62.