Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis

Golnar Karimian1, Manon Buist-Homan1, Martina Schmidt2, Uwe J.F. Tietge3, Jan Freark de Boer3, Karin Klappe4, Jan Willem Kok4, Laurent Combettes5, Thierry Tordjmann5, Klaas Nico Faber1, Han Moshage1
1Dept. of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
2Dept. of Molecular Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
3Dept. of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
4Department of Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
5Institut National de la Santé et de la Recherche Médicale (INSERM) UMR-S 757, Université Paris-sud, Orsay, France

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