Sphingosine impairs mitochondrial function by opening permeability transition pore

Basso, 2005, Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D, J. Biol. Chem., 280, 18558, 10.1074/jbc.C500089200 Cuvillier, 2000, Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells, J. Biol. Chem., 275, 15691, 10.1074/jbc.M000280200 da Silva, 1998, The use of the mitochondrial transmembrane electric potential as an effective biosensor in ecotoxicological research, Chemosphere, 36, 2375, 10.1016/S0045-6535(97)10206-5 Dangel, 2005, Effect of sphingosine on Ca2+ entry and mitochondrial potential of jurkat T cells—interaction with Bcl2, Cell Physiol. Biochem., 16, 9, 10.1159/000087726 Di, 2000, Ceramide interaction with the respiratory chain of heart mitochondria, Biochemistry, 39, 6660, 10.1021/bi9924415 Di, 2004, Ceramide induces release of pro-apoptotic proteins from mitochondria by either a Ca2+ -dependent or a Ca2+ -independent mechanism, J. Bioenerg. Biomembr., 36, 165, 10.1023/B:JOBB.0000023619.97392.0c Favory, 2004, Endotoxin-induced myocardial dysfunction: evidence for a role of sphingosine production, Crit. Care Med., 32, 495, 10.1097/01.CCM.0000109452.36271.FA Garcia-Ruiz, 1997, Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione, J. Biol. Chem., 272, 11369, 10.1074/jbc.272.17.11369 Green, 2004, The pathophysiology of mitochondrial cell death, Science, 305, 626, 10.1126/science.1099320 Gudz, 1997, Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide, J. Biol. Chem., 272, 24154, 10.1074/jbc.272.39.24154 Halestrap, 2002, The permeability transition pore complex: another view, Biochimie, 84, 153, 10.1016/S0300-9084(02)01375-5 Kamo, 1979, Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state, J. Membr. Biol., 49, 105, 10.1007/BF01868720 Kuznetsov, 2004, ‘Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion’, Am. J. Physiol. Heart Circ. Physiol., 286, H1633, 10.1152/ajpheart.00701.2003 McDonough, 1994, Control of cardiac Ca2+ levels. Inhibitory actions of sphingosine on Ca2+ transients and L-type Ca2+ channel conductance, Circ. Res., 75, 981, 10.1161/01.RES.75.6.981 Oral, 1997, Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte, J. Biol. Chem., 272, 4836, 10.1074/jbc.272.8.4836 Plonne, 1999, Separation of the intracellular secretory compartment of rat liver and isolated rat hepatocytes in a single step using self-generating gradients of iodixanol, Anal. Biochem., 276, 88, 10.1006/abio.1999.4311 Prabhu, 2004, Cytokine-induced modulation of cardiac function, Circ. Res., 95, 1140, 10.1161/01.RES.0000150734.79804.92 Rapizzi, 2002, Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria, J. Cell. Biol., 159, 613, 10.1083/jcb.200205091 Renner, 2003, Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells, Biochim. Biophys. Acta, 1642, 115, 10.1016/S0167-4889(03)00105-8 Sabbadini, 1992, The effects of sphingosine on sarcoplasmic reticulum membrane calcium release, J. Biol. Chem., 267, 15475, 10.1016/S0021-9258(19)49559-8 Siskind, 2005, Sphingosine forms channels in membranes that differ greatly from those formed by ceramide, J. Bioenerg. Biomembr., 37, 227, 10.1007/s10863-005-6632-2 Storrie, 1990, Isolation of subcellular organelles, Methods Enzymol., 182, 203, 10.1016/0076-6879(90)82018-W