Sphingosine 1-phosphate receptor agonists attenuate relapsing–remitting experimental autoimmune encephalitis in SJL mice

Brinkmann, 2000, FTY720: a novel transplantation drug that modulates lymphocyte traffic rather than activation, Trends Pharmacol. Sci., 21, 49, 10.1016/S0165-6147(99)01419-4

Brinkmann, 2001, FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression, Transplant. Proc., 33, 530, 10.1016/S0041-1345(00)02126-6

Brinkmann, 2001, FTY720: altered lymphocyte traffic results in allograft protection, Transplantation, 72, 764, 10.1097/00007890-200109150-00002

Brinkmann, 2002, The immune modulator FTY720 targets sphingosine 1-phosphate receptors, J. Biol. Chem., 277, 21453, 10.1074/jbc.C200176200

Brown, 1982, Chronologic neuropathology of relapsing experimental allergic encephalomyelitis in the mouse, Lab. Invest., 46, 171

Chiba, 1996, FTY720, a novel immunosuppressant possessing unique mechanisms: I. Prolongation of skin allograft survival and synergistic effect in combination with cyclosporine in rats, Transplant. Proc., 28, 1056

Chiba, 1998, FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats: I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing, J. Immunol., 160, 5037, 10.4049/jimmunol.160.10.5037

Chun, 1999, Lysophospholipid receptors: implications for neural signaling, Crit. Rev. Neurobiol., 13, 151, 10.1615/CritRevNeurobiol.v13.i2.20

Forrest, 2004, Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes, J. Pharmacol. Exp. Ther., 309, 758, 10.1124/jpet.103.062828

Fujino, 2003, Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment, J. Pharmacol. Exp. Ther., 305, 70, 10.1124/jpet.102.045658

Fukushima, 2001, Lysophospholipid receptors, Annu. Rev. Pharmacol. Toxicol., 41, 507, 10.1146/annurev.pharmtox.41.1.507

Goetzl, 1998, Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine-1-phosphate, FASEB J., 12, 1589, 10.1096/fasebj.12.15.1589

Graler, 2004, The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors, FASEB J., 18, 551, 10.1096/fj.03-0910fje

Hutchings, 1986, Immunological defects in SJL mice, Immunology, 59, 445

Liu, 2002, Estrogen inhibition of EAE involves effects on dendritic cell function, J. Neurosci. Res., 70, 238, 10.1002/jnr.10409

Mandala, 2002, Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists, Science, 296, 346, 10.1126/science.1070238

Matloubian, 2004, Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1, Nature, 427, 355, 10.1038/nature02284

Marracci, 2002, Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis, J. Neuroimmunol., 131, 104, 10.1016/S0165-5728(02)00269-2

Marusic, 2002, Local delivery of granulocyte macrophage colony-stimulating factor by retrovirally transduced antigen-specific T cells leads to severe, chronic experimental autoimmune encephalomyelitis in mice, Neurosci. Lett., 332, 185, 10.1016/S0304-3940(02)00947-3

Masubuchi, 1996, FTY720, a novel immunosuppressant, possessing unique mechanisms: IV. Prevention of graft versus host reactions in rats, Transplant. Proc., 28, 1064

Matsuura, 2000, Effect of FTY720, a novel immunosuppressant, on adjuvant-induced arthritis in rats, Inflamm. Res., 49, 404, 10.1007/s000110050608

McQualter, 2001, Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis, J. Exp. Med., 194, 873, 10.1084/jem.194.7.873

McRae, 1992, Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein, J. Neuroimmunol., 38, 229, 10.1016/0165-5728(92)90016-E

McRae, 1995, Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis, J. Exp. Med., 182, 75, 10.1084/jem.182.1.75

Nagahara, 2000, Evidence that FTY720 induces T cell apoptosis in vivo, Immunopharmacology, 48, 75, 10.1016/S0162-3109(00)00181-8

Pinschewer, 2000, FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory, J. Immunol., 164, 5761, 10.4049/jimmunol.164.11.5761

Re, 2002, Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation, J. Immunol., 169, 2264, 10.4049/jimmunol.169.5.2264

Sanchez, 2003, Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability, J. Biol. Chem., 278, 47281, 10.1074/jbc.M306896200

Sanna, 2004, Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate, J. Biol. Chem., 279, 13839, 10.1074/jbc.M311743200

Sewell, 1989, Inhibition of lymphocyte circulation in mice by pertussis toxin, Immunol. Cell Biol., 67, 291, 10.1038/icb.1989.43

Sobel, 1990, Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein, J. Neuropathol. Exp. Neurol., 49, 468, 10.1097/00005072-199009000-00002

Stevens, 1999, Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice, J. Immunol., 162, 7501, 10.4049/jimmunol.162.12.7501

Suzuki, 1996, A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation, Transplantation, 61, 200, 10.1097/00007890-199601270-00006

Suzuki, 1996, A new immunosuppressant, FTY720, induces bcl-2-associated apoptotic cell death in human lymphocytes, Immunology, 89, 518, 10.1046/j.1365-2567.1996.d01-777.x

Suzuki, 1997, The in vivo induction of lymphocyte apoptosis in MRL-lpr/lpr mice treated with FTY720, Clin. Exp. Immunol., 107, 103, 10.1046/j.1365-2249.1997.d01-885.x

Suzuki, 1998, Prevention of experimentally induced autoimmune type I diabetes in rats by the new immunosuppressive reagent FTY720, Transplant. Proc., 30, 1044, 10.1016/S0041-1345(98)00143-2

Trapp, 1998, Axonal transection in the lesions of multiple sclerosis, N. Engl. J. Med., 338, 278, 10.1056/NEJM199801293380502

Trapp, 1999, Axonal pathology in multiple sclerosis: relationship to neurologic disability, Curr. Opin. Neurol., 12, 295, 10.1097/00019052-199906000-00008

Wujek, 2002, Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis, J. Neuropathol. Exp. Neurol., 61, 23, 10.1093/jnen/61.1.23

Yanagawa, 1998, FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats: II. FTY720 prolongs skin allograft survival by decreasing T cell infiltration into grafts but not cytokine production in vivo, J. Immunol., 160, 5493, 10.4049/jimmunol.160.11.5493

Xie, 2003, Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells, J. Immunol., 170, 3662, 10.4049/jimmunol.170.7.3662