Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells

Cutler, 1991, Antioxidants and aging, Am. J. Clin. Nutr. Suppl., 53, 373S, 10.1093/ajcn/53.1.373S Zs.-nagy, 1991, The horizons of an interdisciplinary synthesis in experimental gerontology, Arch. Gerontol. Geriatr., 12, 329, 10.1016/0167-4943(91)90038-R Ames, 1983, Dietary carcinogens and anticarcinogens, Science, 221, 1256, 10.1126/science.6351251 Vanella, 1982, Superoxide dismutase activity and reduced glutathione content in red blood cells as a function of age, IRCS Med. Sci. Biochem., 10, 235 Vanella, 1982, Superoxide dismutase activities in aging rat brain, Gerontology, 28, 108, 10.1159/000212519 Ames, 1993, Oxidants, antioxidants, and the degenerative diseases of aging, 90, 7915 Enesco, 1980, α-Tocopherol increases life span in the rotifer Philodina, Exp. Gerontol., 15, 335, 10.1016/0531-5565(80)90039-X Hazelton, 1980, Glutathione contents of tissues in the aging mouse, Biochem. J., 188, 25, 10.1042/bj1880025 Ames, 1981, Uric acid provides an antioxidant defense in humans against oxidant-and radical-caused ageing and cancer: A hypothesis, 78, 6858 Comfort, 1971, Effect of ethoxyquin on the longevity of C3H mice, Nature, 229, 254, 10.1038/229254a0 Lovaas, 1991, Antioxidative effects of polyamines, J. Am. Oil Chem. Soc., 68, 353, 10.1007/BF02663749 Lovaas, 1991, Spermine: An anti-oxidant and anti-inflammatory agent, Free Radic. Biol. Med., 11, 455, 10.1016/0891-5849(91)90061-7 Tadolini, 1988, Polyamine inhibition of lipoperoxidation, Biochem. J., 249, 33, 10.1042/bj2490033 Schuber, 1989, Influence of polyamines on membrane function, Biochem. J., 260, 1, 10.1042/bj2600001 Tabor, 1984, Polyamines, Annu. Rev. Biochem., 53, 749, 10.1146/annurev.bi.53.070184.003533 Heby, 1981, Role of polyamines in the control of cell proliferation and differentiation, Differentiation, 19, 1, 10.1111/j.1432-0436.1981.tb01123.x Bueb, 1994, Modulation of extracellular signal by polyamines through their interactions with receptors, ion channels and G-proteins, 97 Bueb, 1992, Natural polyamines stimulate G-proteins, Biochem. J., 282, 545, 10.1042/bj2820545 Shigematsu, 1994, Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N′-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278), Mutagenesis, 9, 355, 10.1093/mutage/9.4.355 Held, 1991, Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA, Int. J. Radiat. Biol., 59, 699, 10.1080/09553009114550611 Gerner, 1988, Inhibition of ionizing radiation recovery process in polyamine-depleted chinese hamster cells, Cancer Res., 48, 4881 Schaich, 1980, Free radical initiation in proteins and amino acids by ionizing and ultraviolet radiations and lipid oxidation-Part III: Free radical transfer from oxidizing lipids, CRC Crit. Rev. Food Sci. Nutr., 13, 188 Davies, 1987, Protein damage and degradation by oxygen radicals. I. General aspects, J. Biol. Chem., 262, 9895, 10.1016/S0021-9258(18)48018-0 Wolff, 1986, Free radicals, lipids, and protein degradation, Trends Biochem. Sci., 11, 27, 10.1016/0968-0004(86)90228-8 Brawn, 1981, DNA strand scission by enzymatically generated oxygen radicals, Arch. Biochem. Biophys., 206, 414, 10.1016/0003-9861(81)90108-9 Richter, 1992, Reactive oxygen and DNA damage in mitochondria, Mutat. Res. DNAging Genet. Instability Aging, 275, 249, 10.1016/0921-8734(92)90029-O Fridovich, 1978, The biology of oxygen radicals, Science, 201, 875, 10.1126/science.210504 Grisham, 1992, Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects, Dig. Dis. Sci., 37, 1383, 10.1007/BF01296008 Sevanian, 1985, Mechanisms and consequences of lipid peroxidation in biological systems, Annu. Rev. Nutr., 5, 365, 10.1146/annurev.nu.05.070185.002053 Kanner, 1987, Initiation of lipid peroxidation in biological systems, CRC Crit. Rev. Food Sci. Nutr., 25, 317, 10.1080/10408398709527457 Esterbaner, 1993, Lipid peroxidation and its role in atherosclerosis, Br. Med. Bull., 49, 566, 10.1093/oxfordjournals.bmb.a072631 Donato, 1981, Age pigments, 63 Lovaas, 1974, Evidence for a proteolytic system i rat liver mitochondria, FEBS Lett., 45, 244, 10.1016/0014-5793(74)80853-7 Glees, 1982, Electron microscopic studies on neural lipofuscin: Accumulation and removal, 385 Dillard, 1971, Fluorescent products of lipid peroxidation of mitochondria and microsomes, Lipids, 6, 715, 10.1007/BF02531296 Tappel, 1973, Effects of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse, J. Gerontol., 28, 415, 10.1093/geronj/28.4.415 Kikugawa, 1987, Involvement of lipid oxidation products in the formation of fluorescent and cross-linked proteins, Chem. Phys. Lipids, 44, 277, 10.1016/0009-3084(87)90054-5 Gey, 1990, The antioxidant hypothesis of cardiovascular disease: Epidemiology and mechanisms, Biochem. Soc. Trans., 18, 1041, 10.1042/bst0181041 Janero, 1991, Therapeutic potential of vitamin E against myocardial ischemic-reperfusion injury, Free Radic. Biol. Med., 10, 315, 10.1016/0891-5849(91)90038-5 Bast, 1991, Oxidants and antioxidants: State of the art, Am. J. Med., 91, 2S, 10.1016/0002-9343(91)90278-6 Galaris, 1980, Improved methods for automatic monitoring of contracting heart cells in culture, J. Biochem. Biophys. Methods, 2, 213, 10.1016/0165-022X(80)90036-6 Sohal, 1989, Effect of ambient oxygen concentration on lipofuscin accumulation in cultures rat heart myocytes-A novel in vitro model of lipofuscinogenesis, Free Radic. Biol. Med., 6, 23, 10.1016/0891-5849(89)90155-X Zdolsek, 1993, Visualization of iron in cultured macrophages: A cytochemical light and electron microscopic study using autometallography, Free Radic. Biol. Med., 15, 1, 10.1016/0891-5849(93)90120-J Danscher, 1981, Localization of gold in biological tissues, Histochemistry, 71, 81, 10.1007/BF00592572 Thaw, 1987, Optimal conditions for measurement of lipid peroxidation products (lipofuscin) in individual cultivated human glial and glioma cells, Mech. Ageing Dev., 38, 79, 10.1016/0047-6374(87)90112-6 Marzabadi, 1990, Effect of a-tocopherol and some metal chelators on lipofuscin accumulation in cultured neonatal rat cardiac myocytes, Anal. Cell Pathol., 2, 333 Rundquist, 1981, A flexible system for microscope fluoremetry served by a personal computer, Histochemistry, 70, 151, 10.1007/BF00493207 Thaw, 1983, A versatile system for multiparametric analysis of cells, Microscopica Acta, 87, 159 Rundquist, 1985, A simple microcomputer system for microscope fluorometry, 335 Brunk, 1981, Lysosomes and age pigments in cultured cells, 243 Deamer, 1974, Autofluorescence structures in cultures WI-38 cells, Arch. Biochem. Biophys., 165, 421, 10.1016/0003-9861(74)90181-7 Jongkind, 1982, Isolation of autofluorescent “aged” human fibroblasts by flow sorting, Exp. Cell Res., 138, 409, 10.1016/0014-4827(82)90189-6 Poot, 1985, Autofluorescence of human skin fibroblasts during growth inhibition and in vitro ageing, Gerontology, 31, 158, 10.1159/000212697 Marzabadi, 1991, Effect of ferric iron and desferrioxamine on lipofuscin accumulation in cultured rat heart myocytes, Mech. Ageing Dev. Von Zglinicki, 1993, Intracellular interactions under oxidative stress and aging: A hypothesis, Z. Gerontol., 26, 215 Brunk, 1992, A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis, Mutat. Res., 275, 395, 10.1016/0921-8734(92)90042-N Palmer, 1974, Complex formation between 4,9-diazadodecane-1,12-diamine (spermine) and copper(II) ions and protons in aqueous solution, J. C. S. Dalton, 2086, 10.1039/dt9740002086 Lovaas, 1994, Antiinflammatory and metal chelating effect of polyamines, 161 Boggs, 1975, Spermine copper(II) perchlorate, Acta Cryst., B31, 320, 10.1107/S0567740875002658 Halliwell, 1986, Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts, Arch. Biochem. Biophys., 246, 501, 10.1016/0003-9861(86)90305-X Holt, 1986, Myocardial tissue iron delocalization and evidence for lipid peroxidation after two hours of ischemia, Ann. Emerg. Med., 15, 1155, 10.1016/S0196-0644(86)80857-5 Koster, 1986, Ferritin: A physiological iron donor for microsomal lipid peroxidation, FEBS Lett., 199, 85, 10.1016/0014-5793(86)81228-5 Boucher, 1992, Evidence of cytosolic iron release during post-ischaemic reperfusion of isolated rat hearts. Influence on spin-trapping experiments with DMPO, FEBS Lett., 302, 261, 10.1016/0014-5793(92)80455-P Biemond, 1988, Superoxide dependent iron release from ferritin in inflammatory diseases, Free Radic. Biol. Med., 4, 185, 10.1016/0891-5849(88)90026-3 Jenkins, 1993, Influence of exercise on clearance of oxidant stress products and loosely bound iron, Med. Sci. Sports Exerc., 25, 213, 10.1249/00005768-199302000-00009 Voogd, 1992, Low molecular weight iron and the oxygen paradox in isolated rat hearts, J. Clin. Invest., 90, 2050, 10.1172/JCI116086 Puchea, 1993, Effect of iron overload in the isolated ischemic and reperfused rat heart, Cardiovasc. Drugs Ther., 7, 701, 10.1007/BF00877824 Karwatowska-Prokopczuk, 1992, Iron availability and free radical induced injury in the isolated ischaemic reperfused rat heart, Cardiovasc. Res., 26, 58, 10.1093/cvr/26.1.58 Magnusson, 1994, Low iron-binding capacity as a risk factor for myocardial infarction, Circulation, 89, 102, 10.1161/01.CIR.89.1.102 Bernier, 1986, Reperfusion-induced arrhythmias and oxygen-derived free radicals, Circ. Res., 58, 331, 10.1161/01.RES.58.3.331 Jenner, 1992, New insights into the cause of Parkinson's disease, Neurology, 42, 2241, 10.1212/WNL.42.12.2241 Palmer, 1994, Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease, Brain Res., 645, 338, 10.1016/0006-8993(94)91670-5 delemos, 1990, Toxic effects associated with the administration of deferoxamine in the premature baboon with hyaline membrane disease, Am. J. Dis. Child, 144, 915 Davis, 1990, Management of polyamine pools and the regulation of ornithine decarboxylase, J. Cell. Biochem., 44, 199, 10.1002/jcb.240440402 Khan, 1991, Polyamine membrane transport regulation, Cell Biol. Int. Rep., 15, 9, 10.1016/0309-1651(91)90078-W Gilad, 1991, Polyamine uptake, binding and release in rat brain, Eur. I. Pharmacol., 193, 41, 10.1016/0014-2999(91)90198-Y Colombatto, 1991, Difference in polyamine transport in human B and T lymphocytes, Biol. Chem. Hoppe Seyler, 372, 75, 10.1515/bchm3.1991.372.1.75 Iseki, 1991, Spermine uptake by rat intestinal brush-border membrane vesicles, Biochim. Biophys. Acta Biol-membr., 1068, 105, 10.1016/0005-2736(91)90067-I