Spermidine in dementia
Tóm tắt
Previous studies have highlighted that spermidine has the ability to trigger the
important process of dissolving amyloid-beta plaques by autophagy. This manuscript
focuses on the correlation of serum spermidine levels between age and between
performance in mini-mental state examinations. It will serve as a premise for an ongoing
multicentric placebo-controlled study, which focuses on the effect of oral spermidine
supplementation on memory performance. Memory tests were carried out on 80 subjects aged
60–96 years old in 6 nursing homes in Styria. Blood samples were taken for the
determination of spermidine concentration. The results showed a significant correlation
between the spermidine concentration and the mini-mental state examination score
(p = 0.025). On the basis of the dependence
demonstrated it can be concluded that spermidine might be suitable as a biomarker for
the diagnosis of neurocognitive changes (senile dementia or Alzheimer’s disease).
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