Spermidine in dementia

Wiener klinische Wochenschrift - Tập 132 - Trang 42-46 - 2019
Thomas Pekar1, Aribert Wendzel2, Walter Flak3, Alexandra Kremer4, Susanne Pauschenwein-Frantsich1, Anna Gschaider1, Felix Wantke5, Reinhart Jarisch5,6
1Biomedical Science, University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria
2Gepflegt Wohnen GmbH, Allerheiligen bei Wildon, Austria
3Federal Office for Viticulture, Eisenstadt, Austria
4Privatklinik Rudolfinerhaus GmbH, Vienna, Austria
5FAZ Floridsdorfer Allergiezentrum, Vienna, Austria
6Jarisch&Co GmbH, Vienna, Austria

Tóm tắt

Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60–96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer’s disease).

Tài liệu tham khảo

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