Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Sự liên kết giữa tốc độ phát âm và độ khuếch tán chất trắng tiểu não ở người lớn mắc chứng ợn ngực phát triển kéo dài
Tóm tắt
Tốc độ phát âm là một đặc điểm cơ bản của sản xuất ngôn ngữ, ảnh hưởng đến khả năng hiểu và hiệu quả giao tiếp của người nói. Nhiều rối loạn lời nói, bao gồm chứng ợn ngực phát triển kéo dài, có tốc độ phát âm thay đổi. Cụ thể, người lớn mắc chứng ợn ngực (AWS) thường thể hiện tốc độ phát âm chậm hơn so với những người nói lưu loát. Bằng chứng từ các nghiên cứu hình ảnh cho thấy tiểu não có vai trò trong việc kiểm soát tốc độ sản xuất lời nói. Những người mắc chứng ợn ngực cho thấy sự bất thường về cấu trúc và chức năng trong tiểu não. Tuy nhiên, sự tham gia của các đường dẫn tiểu não trong việc kiểm soát tốc độ phát âm vẫn chưa được khám phá. Ở đây, chúng tôi đánh giá mối liên kết của các cuống tiểu não với tốc độ phát âm ở AWS và các diễn giả đối chứng. Dữ liệu MRI khuếch tán và tốc độ phát âm đã được thu thập từ 42 người tham gia (23 AWS, 19 người đối chứng). Chúng tôi đã sử dụng phương pháp theo dõi đường định hướng với phân đoạn và định lượng sợi tự động (AFQ) để xác định các cuống tiểu não trên, giữa và dưới (SCP, MCP, ICP) ở cả hai bên, và định lượng độ dị hướng phân tử (FA) và độ khuếch tán trung bình (MD) dọc theo mỗi đường dẫn. Không có sự khác biệt đáng kể nào giữa AWS và người đối chứng trong các giá trị khuếch tán của các cuống tiểu não. Tuy nhiên, AWS cho thấy một mối liên hệ tiêu cực đáng kể giữa tốc độ phát âm và FA trong ICP bên trái, một đường dẫn chính của tiểu não truyền tải tín hiệu phản hồi cảm giác từ nhân olivary vào tiểu não. Sự tham gia của ICP trong việc kiểm soát sản xuất lời nói ở AWS tương thích với quan điểm cho rằng chứng ợn ngực bắt nguồn từ việc giám sát lời nói quá mức, nơi ngay cả những sai lệch nhỏ so với kế hoạch phát âm cũng được coi là lỗi. Kết luận, những phát hiện của chúng tôi gợi ý một cơ chế thần kinh khả thi cho sự giảm tốc độ phát âm được quan sát ở AWS.
Từ khóa
#tốc độ phát âm; chứng ợn ngực; tiểu não; khuếch tán chất trắng; người lớnTài liệu tham khảo
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