Anjali Mohapatra1, Shailesh Kakde1, Vellaichamy M. Annapandian2,1, Anna T. Valson1, Neelaveni Duhli3, Anila Korula3, Smita Mary Matthai4, Anna Pulimood4, Vinoi George David1, Suceena Alexander1, Shibu Jacob1, Santosh Varughese1, Gopal Basu5,1, V Tamilarasi1, George John1,6
1Department of Nephrology, Christian Medical College and Hospital, Vellore, India
2Academic Research Department Narayana Hrudayalaya Foundations Bangalore India
3Department of Pathology, Christian Medical College and Hospital, Vellore, India
4Central Electron Microscopy Unit Christian Medical College and Hospital Vellore India
5Department of Nephrology Central Northern Adelaide Renal and Transplant Service Adelaide South Australia Australia
6Department of Renal Medicine, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, Australia
Tóm tắt
ABSTRACTAimWe report findings from a large single centre paediatric renal biopsy cohort in South Asia.MethodsWe analyzed all renal biopsies performed on children aged ≤18 years between 1996 and 2015 at our centre. The clinical characteristics and histological diagnosis pertaining to each case, distribution of renal diseases in children with various clinical presentations, and changes in the pattern of kidney disease during the study period were analyzed.ResultsA total of 1740 paediatric kidney biopsies were performed during the study period. The mean age was 12.8 ± 4.9 years (8 months to 18 years) and the male: female ratio was 1.5:1. The most common indication for renal biopsy was nephrotic syndrome (63.2%) followed by acute nephritic syndrome (13%). Minimal change disease was the most common cause of nephrotic syndrome while endocapillary proliferative glomerulonephritis (65.7% infection related), remained the commonest cause of acute nephritic syndrome. IgA nephropathy was the commonest cause of chronic kidney disease. Contrary to trends in European paediatric cohorts, the frequency of lupus nephritis increased over the two decades of the study, while that of endocapillary proliferative glomerulonephritis did not show any appreciable decline.ConclusionThis study provides the largest data on biopsy proven renal disease in children from South Asia published till date and highlights important differences in the spectrum and trends of kidney disease compared to data from other regions.
