Specific targeting to B cells by lipid-based nanoparticles conjugated with a novel CD22-ScFv

Experimental and Molecular Pathology - Tập 88 - Trang 238-249 - 2010
Kristin Loomis1, Brandon Smith1, Yang Feng1, Himanshu Garg1, Amichai Yavlovich1, Ryan Campbell-Massa1, Dimiter S. Dimitrov1, Robert Blumenthal1, Xiaodong Xiao1, Anu Puri1
1Center for Cancer Research Nanobiology Program, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA

Tài liệu tham khảo

Tedder, 1997, CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling, Annu. Rev. Immunol., 15, 481, 10.1146/annurev.immunol.15.1.481 Shan, 1995, Constitutive endocytosis and degradation of CD22 by human B cells, J. Immunol., 154, 4466, 10.4049/jimmunol.154.9.4466 Sato, 1998, CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor, Semin. Immunol., 10, 287, 10.1006/smim.1998.0121 Dorken, 1986, HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes, J. Immunol., 136, 4470, 10.4049/jimmunol.136.12.4470 Schwarting, 1985, The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia, Blood, 65, 974, 10.1182/blood.V65.4.974.974 Sliedregt, 2001, Design and synthesis of a multivalent homing device for targeting to murine CD22, Bioorg. Med. Chem., 9, 85, 10.1016/S0968-0896(00)00224-8 Siegel, 2003, CD22-directed monoclonal antibody therapy for lymphoma, Semin. Oncol., 30, 457, 10.1016/S0093-7754(03)00240-9 Leonard, 2003, Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma, J. Clin. Oncol., 21, 3051, 10.1200/JCO.2003.01.082 Leonard, 2004, Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: phase I/II clinical trial results, Clin. Cancer Res., 10, 5327, 10.1158/1078-0432.CCR-04-0294 Leonard, 2005, Combination antibody therapy with epratuzumab and rituximab in relapsed or refractory non-Hodgkin's lymphoma, J. Clin. Oncol., 23, 5044, 10.1200/JCO.2005.13.821 Furman, 2004, Epratuzumab in non-Hodgkin's lymphomas, Curr. Treat. Options Oncol., 5, 283, 10.1007/s11864-004-0019-1 Coleman, 2003, Epratuzumab: targeting B-cell malignancies through CD22, Clin. Cancer Res., 9, 3991S Carnahan, 2003, Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties, Clin. Cancer Res., 9, 3982S Carnahan, 2007, Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab, Mol. Immunol., 44, 1331, 10.1016/j.molimm.2006.05.007 Krauss, 2005, Targeting malignant B-cell lymphoma with a humanized anti-CD22 scFv-angiogenin immunoenzymedouble dagger, Br. J. Haematol., 128, 602, 10.1111/j.1365-2141.2005.05356.x Ho, 2005, In vitro antibody evolution targeting germline hot spots to increase activity of an anti-CD22 immunotoxin, J. Biol. Chem., 280, 607, 10.1074/jbc.M409783200 DiJoseph, 2004, Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies, Blood, 103, 1807, 10.1182/blood-2003-07-2466 DiJoseph, 2005, Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22, Cancer Immunol. Immunother., 54, 11, 10.1007/s00262-004-0572-2 DiJoseph, 2006, Antitumor efficacy of a combination of CMC-544 (inotuzumab ozogamicin), a CD22-targeted cytotoxic immunoconjugate of calicheamicin, and rituximab against non-Hodgkin's B-cell lymphoma, Clin. Cancer Res., 12, 242, 10.1158/1078-0432.CCR-05-1905 Weldon, 2009, A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity, Blood, 113, 3792, 10.1182/blood-2008-08-173195 Onda, 2008, An immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes, Proc. Natl. Acad. Sci. U. S. A., 105, 11311, 10.1073/pnas.0804851105 Li, 2006, Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma, Cancer Res., 66, 10586, 10.1158/0008-5472.CAN-06-1981 Bang, 2005, HA22 (R490A) is a recombinant immunotoxin with increased antitumor activity without an increase in animal toxicity, Clin. Cancer Res., 11, 1545, 10.1158/1078-0432.CCR-04-1939 Allen, 2002, Ligand-targeted therapeutics in anticancer therapy, Nat. Rev. Cancer, 2, 750, 10.1038/nrc903 Torchilin, 2007, Targeted pharmaceutical nanocarriers for cancer therapy and imaging, AAPS J., 9, E128, 10.1208/aapsj0902015 Sapra, 2004, Improved outcome when B-cell lymphoma is treated with combinations of immunoliposomal anticancer drugs targeted to both the CD19 and CD20 epitopes, Clin. Cancer Res., 10, 2530, 10.1158/1078-0432.CCR-03-0376 Sapra, 2004, Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab′ fragments, Clin. Cancer Res., 10, 1100, 10.1158/1078-0432.CCR-03-0041 Nellis, 2005, Preclinical manufacture of anti-HER2 liposome-inserting, scFv-PEG-lipid conjugate. 2. Conjugate micelle identity, purity, stability, and potency analysis, Biotechnol. Prog., 21, 221, 10.1021/bp049839z Laginha, 2008, Bioavailability and therapeutic efficacy of HER2 scFv-targeted liposomal doxorubicin in a murine model of HER2-overexpressing breast cancer, J. Drug Target., 16, 605, 10.1080/10611860802229978 Xu, 2001, Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFv, Mol. Med., 7, 723, 10.1007/BF03401962 Xu, 2002, Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes, Mol. Cancer Ther., 1, 337 Zhang, 2008, Tumor targeting of vincristine by mBAFF-modified PEG liposomes in B lymphoma cells, Cancer Lett., 269, 26, 10.1016/j.canlet.2008.04.024 O'Donnell, 2009, Development and characterization of CD22-targeted pegylated-liposomal doxorubicin (IL-PLD), Invest. New Drugs Sapra, 2003, Ligand-targeted liposomal anticancer drugs, Prog. Lipid Res., 42, 439, 10.1016/S0163-7827(03)00032-8 Lian, 2001, Trends and developments in liposome drug delivery systems, J. Pharm. Sci., 90, 667, 10.1002/jps.1023 Kirpotin, 2006, Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models, Cancer Res., 66, 6732, 10.1158/0008-5472.CAN-05-4199 de, 1996, Biosynthetically lipid-modified human scFv fragments from phage display libraries as targeting molecules for immunoliposomes, FEBS Lett., 399, 232, 10.1016/S0014-5793(96)01335-X Dekruif, 1995, Rapid selection of cell subpopulation-specific human monoclonal-antibodies from a synthetic phage antibody library, Proc. Natl Acad. Sci. U. S. A., 92, 3938, 10.1073/pnas.92.9.3938 Gupta, 1981, Carbamyl analogs of phosphatidylcholines. Synthesis, interaction with phospholipases and permeability behavior of their liposomes, Biochim. Biophys. Acta, 663, 506, 10.1016/0005-2760(81)90178-8 Goswami, 1971, Spray detection of phospholipids on thin-layer chromatograms, J. Lipid Res., 12, 509, 10.1016/S0022-2275(20)39502-X Puri, 2008, HER2-specific affibody-conjugated thermosensitive liposomes (Affisomes) for improved delivery of anticancer agents, J. Liposome Res., 18, 293, 10.1080/08982100802457377 Ames, 1960, The role of polyamines in the neutralization of bacteriophage deoxyribonucleic acid, J. Biol. Chem., 235, 769, 10.1016/S0021-9258(19)67936-6 Haran, 1993, Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases, Biochim. Biophys. Acta, 1151, 201, 10.1016/0005-2736(93)90105-9 Zhu, 2005, Surface modification of liposomes by saccharides: vesicle size and stability of lactosyl liposomes studied by photon correlation spectroscopy, J. Colloid. Interface Sci., 289, 542, 10.1016/j.jcis.2005.03.088 Rawat, 2004, Functional expression of CD4, CXCR4, and CCR5 in glycosphingolipid-deficient mouse melanoma GM95 cells and susceptibility to HIV-1 envelope glycoprotein-triggered membrane fusion, Virology, 318, 55, 10.1016/j.virol.2003.08.042 Xiong, 2010, The therapeutic response to multifunctional polymeric nano-conjugates in the targeted cellular and subcellular delivery of doxorubicin, Biomaterials, 31, 757, 10.1016/j.biomaterials.2009.09.080 Marty, 2005, Cytotoxic tumor targeting with scFv antibody-modified liposomes, Methods Mol. Med., 109, 389 Yatvin, 1978, Design of liposomes for enhanced local release of drugs by hyperthermia, Science, 202, 1290, 10.1126/science.364652 Nellis, 2005, Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification, Biotechnol. Prog., 21, 205, 10.1021/bp049840y Houck, 1987, The role of multivalency in antibody mediated liposome targeting, Biochem. Biophys. Res. Commun., 145, 1205, 10.1016/0006-291X(87)91565-8 Park, 2004, Future directions of liposome- and immunoliposome-based cancer therapeutics, Semin. Oncol., 31, 196, 10.1053/j.seminoncol.2004.08.009 Dimitrov, 2009, Therapeutic antibodies: current state and future trends—is a paradigm change coming soon?, Methods Mol. Biol., 525, 1, 10.1007/978-1-59745-554-1_1