Specific class of intrapartum antibiotics relates to maturation of the infant gut microbiota: a prospective cohort study

BJOG: An International Journal of Obstetrics and Gynaecology - Tập 127 Số 2 - Trang 217-227 - 2020
Modupe O. Coker1, AG Hoen2,1, Erika F. Dade1, Sara Lundgren1, Z Li3, Athena Wong4, Michael S. Zens1, Thomas J. Palys1, HG Morrison5, ML Sogin5, Emily Baker6, MR Karagas2,1, Juliette C. Madan1,6
1Department of Epidemiology The Geisel School of Medicine at Dartmouth Hanover NH USA
2Center for Molecular Epidemiology The Geisel School of Medicine at Dartmouth Hanover NH USA
3Department of Biostatistics, University of Florida, Gainesville, FL, USA
4The Dartmouth Institute Lebanon NH USA
5Josephine Bay Paul Center, Marine Biological Laboratory, Woods Hole, MA, USA
6Division of Neonatology Department of Pediatrics Children's Hospital at Dartmouth Lebanon NH USA

Tóm tắt

ObjectiveTo evaluate the potential impact of intrapartum antibiotics, and their specific classes, on the infant gut microbiota in the first year of life.DesignProspective study of infants in the New Hampshire Birth Cohort Study (NHBCS).SettingsRural New Hampshire, USA.Population or sampleTwo hundred and sixty‐six full‐term infants from the NHBCS.MethodsIntrapartum antibiotic use during labour and delivery was abstracted from medical records. Faecal samples collected at 6 weeks and 1 year of age were characterised by 16S rRNA sequencing, and metagenomics analysis in a subset of samples.ExposuresMaternal exposure to antibiotics during labour and delivery.Main outcome measureTaxonomic and functional profiles of faecal samples.ResultsInfant exposure to intrapartum antibiotics, particularly to two or more antibiotic classes, was independently associated with lower microbial diversity scores as well as a unique bacterial community at 6 weeks (GUnifrac, P = 0.02). At 1 year, infants in the penicillin‐only group had significantly lower α diversity scores than infants not exposed to intrapartum antibiotics. Within the first year of life, intrapartum exposure to penicillins was related to a significantly lower increase in several taxa including Bacteroides, use of cephalosporins was associated with a significantly lower rise over time in Bifidobacterium and infants in the multi‐class group experienced a significantly higher increase in Veillonella dispar.ConclusionsOur findings suggest that intrapartum antibiotics alter the developmental trajectory of the infant gut microbiome, and specific antibiotic types may impact community composition, diversity and keystone immune training taxa.Tweetable abstractClass of intrapartum antibiotics administered during delivery relates to maturation of infant gut microbiota.

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BJOG: An International Journal of Obstetrics and Gynaecology

Tập 127 Số 2

217-227

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