Specific alterations of regional myocardial work in strength-trained athletes using anabolic androgenic steroids compared to athletes with genetic hypertrophic cardiomyopathy

Weiner, 2012, Exercise-induced cardiac remodeling, Prog Cardiovasc Dis, 54, 380, 10.1016/j.pcad.2012.01.006 Utomi, 2013, Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athlete's heart, Heart, 99, 1727, 10.1136/heartjnl-2012-303465 Sheikh, 2015, Clinical profile of athletes with hypertrophic cardiomyopathy, Circ Cardiovasc Imaging, 8, 10.1161/CIRCIMAGING.114.003454 Baggish, 2017, Cardiovascular toxicity of illicit anabolic-androgenic steroid use, Circulation, 135, 1991, 10.1161/CIRCULATIONAHA.116.026945 Maron, 2006, The heart of trained athletes, Circulation, 114, 1633, 10.1161/CIRCULATIONAHA.106.613562 Pope, 2014, The lifetime prevalence of anabolic-androgenic steroid use and dependence in Americans: Current best estimates, Am J Addict, 23, 371, 10.1111/j.1521-0391.2013.12118.x Fineschi, 2007, Sudden cardiac death during anabolic steroid abuse: Morphologic and toxicologic findings in two fatal cases of bodybuilders, Int J Legal Med, 121, 48, 10.1007/s00414-005-0055-9 Montisci, 2012, Anabolic androgenic steroids abuse and cardiac death in athletes: Morphological and toxicological findings in four fatal cases, Forensic Sci Int, 217, e13, 10.1016/j.forsciint.2011.10.032 Angell, 2012, Anabolic steroids and cardiovascular risk, Sports Med, 42, 119, 10.2165/11598060-000000000-00000 Baggish, 2010, Long term anabolic-androgenic steroid use is associated with left ventricular dysfunction, Circ Heart Fail, 3, 472, 10.1161/CIRCHEARTFAILURE.109.931063 Dickerman, 1997, Left ventricular size and function in elite bodybuilders using anabolic steroids, Clin J Sport Med, 7, 90, 10.1097/00042752-199704000-00003 Nottin, 2006, Cardiovascular effects of androgenic anabolic steroids in male bodybuilders determined by tissue Doppler imaging, Am J Cardiol, 97, 912, 10.1016/j.amjcard.2005.10.026 D'Andrea, 2007, Left ventricular early myocardial dysfunction after chronic misuse of anabolic androgenic steroids: A Doppler myocardial and strain imaging analysis, Br J Sports Med, 41, 149, 10.1136/bjsm.2006.030171 Luijkx, 2013, Anabolic androgenic steroid use is associated with ventricular dysfunction on cardiac MRI in strength trained athletes, Int J Cardiol, 167, 664, 10.1016/j.ijcard.2012.03.072 Pirompol, 2016, Supra-physiological dose of testosterone induces pathological cardiac hypertrophy, J Endocrinol, 229, 13, 10.1530/JOE-15-0506 De Mello, 2000, Angiotensin II and the Heart, Hypertension, 35, 1183, 10.1161/01.HYP.35.6.1183 Maron, 2006, Abstract 3872: Profile and frequency of sudden deaths in 1463 young competitive athletes: From a 25-year U.S. National Registry, 1980–2005, Circulation, 114 Yang, 2003, Use of strain imaging in detecting segmental dysfunction in patients with hypertrophic cardiomyopathy, J Am Soc Echocardiogr, 16, 233, 10.1067/mje.2003.60 Maron, 2012, Genetics of hypertrophic cardiomyopathy after 20 years: Clinical perspectives, J Am Coll Cardiol, 60, 705, 10.1016/j.jacc.2012.02.068 Russell, 2012, A novel clinical method for quantification of regional left ventricular pressure–strain loop area: A non-invasive index of myocardial work, Eur Heart J, 33, 724, 10.1093/eurheartj/ehs016 Russell, 2013, Assessment of wasted myocardial work: A novel method to quantify energy loss due to uncoordinated left ventricular contractions, Am J Physiol Heart Circ Physiol, 305, H996, 10.1152/ajpheart.00191.2013 Smiseth, 2021, How to measure left ventricular myocardial work by pressure–strain loops, Eur Heart J Cardiovasc Imaging, 22, 259, 10.1093/ehjci/jeaa301 Elliott, 2014, 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: The task force for the diagnosis and management of hypertrophic cardiomyopathy of the European Society of Cardiology (ESC), Eur Heart J, 35, 2733, 10.1093/eurheartj/ehu284 Lang, 2015, Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging, Eur Heart J Cardiovasc Imaging, 16, 233, 10.1093/ehjci/jev014 Maufrais, 2014, Endurance training minimizes age-related changes of left ventricular twist-untwist mechanics, J Am Soc Echocardiogr, 27, 1208, 10.1016/j.echo.2014.07.007 Nagueh, 2009, Echocardiographic assessment of left ventricular relaxation and cardiac filling pressures, Curr Heart Fail Rep, 6, 154, 10.1007/s11897-009-0022-8 Purushottam, 2011, Dyssynchrony in obese subjects without a history of cardiac disease using velocity vector imaging, J Am Soc Echocardiogr, 24, 98, 10.1016/j.echo.2010.10.003 Grandperrin, 2021, Left ventricular dyssynchrony and post-systolic shortening in young bodybuilders using anabolic-androgenic steroids, Am J Physiol Heart Circ Physiol, 321, H509, 10.1152/ajpheart.00136.2021 Hubert, 2018, Estimation of myocardial work from pressure–strain loops analysis: An experimental evaluation, Eur Heart J Cardiovasc Imaging, 19, 1372, 10.1093/ehjci/jey024 Rocha, 2007, Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats, Am J Physiol Heart Circ Physiol, 293, H3575, 10.1152/ajpheart.01251.2006 Reant, 2015, Clinical and imaging description of the Maron subtypes of hypertrophic cardiomyopathy, Int J Cardiovasc Imaging, 31, 47, 10.1007/s10554-014-0529-2 Pelliccia, 2012, Assessment of left ventricular hypertrophy in a trained athlete: Differential diagnosis of physiologic athlete's heart from pathologic hypertrophy, Prog Cardiovasc Dis, 54, 387, 10.1016/j.pcad.2012.01.003 Richand, 2007, An ultrasound speckle tracking (two-dimensional strain) analysis of myocardial deformation in professional soccer players compared with healthy subjects and hypertrophic cardiomyopathy, Am J Cardiol, 100, 128, 10.1016/j.amjcard.2007.02.063 Serri, 2006, Global and regional myocardial function quantification by two-dimensional strain, J Am Coll Cardiol, 47, 1175, 10.1016/j.jacc.2005.10.061 Caselli, 2014, Differentiating left ventricular hypertrophy in athletes from that in patients with hypertrophic cardiomyopathy, Am J Cardiol, 114, 1383, 10.1016/j.amjcard.2014.07.070 Stokke, 2017, Geometry as a confounder when assessing ventricular systolic function: Comparison between ejection fraction and strain, J Am Coll Cardiol, 70, 942, 10.1016/j.jacc.2017.06.046 Montisci, 2012, Anabolic androgenic steroids abuse and cardiac death in athletes: Morphological and toxicological findings in four fatal cases, Forensic Sci Int, 217, e13, 10.1016/j.forsciint.2011.10.032 Kirk, 2013, Electromechanical dyssynchrony and resynchronization of the failing heart, Circ Res, 113, 765, 10.1161/CIRCRESAHA.113.300270 Tigen, 2010, Diffuse late gadolinium enhancement by cardiovascular magnetic resonance predicts significant intraventricular systolic dyssynchrony in patients with non-ischemic dilated cardiomyopathy, J Am Soc Echocardiogr, 23, 416, 10.1016/j.echo.2009.12.022 Galli, 2019, Myocardial constructive work is impaired in hypertrophic cardiomyopathy and predicts left ventricular fibrosis, Echocardiography, 36, 74, 10.1111/echo.14210 D'Andrea, 2020, Speckle tracking evaluation in endurance Athletes: The “optimal” myocardial work, Int J Cardiovasc Imaging, 36, 1679, 10.1007/s10554-020-01871-z Hiemstra, 2020, Myocardial work in nonobstructive hypertrophic cardiomyopathy: Implications for outcome, J Am Soc Echocardiogr, 33, 1201, 10.1016/j.echo.2020.05.010 Vecera, 2016, Wasted septal work in left ventricular dyssynchrony: A novel principle to predict response to cardiac resynchronization therapy, Eur Heart J Cardiovasc Imaging, 17, 624, 10.1093/ehjci/jew019 Limongelli, 2021, Yield and clinical significance of genetic screening in elite and amateur athletes, Eur J Prev Cardiol, 28, 1081, 10.1177/2047487320934265