Spatiotemporal Patterns of Ozone and Cardiovascular and Respiratory Disease Mortalities Due to Ozone in Shenzhen

Sustainability - Tập 9 Số 4 - Trang 559
Li Wang1, Yu Bai2, Fengying Zhang2,1, Sheng Wang3, Xiaojian Liu4, Thomas Krafft1
1Faculty of Health, Medicine and Life Sciences, Maastricht University, MD 6200 Maastricht, The Netherlands
2China National Environmental Monitoring Centre, Beijing 100012, China
3Key Laboratory of Land Surface Pattern and Simulation, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China
4Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China

Tóm tắt

In order to explore the temporal-spatial patterns and possible health effects of ozone in Shenzhen, daily concentrations of ozone and the daily mortality caused by cardiovascular and respiratory diseases were collected. Using Geographic Information System (GIS) and SPSS, the spatial and temporal patterns of ozone in Shenzhen were illustrated. Using a generalized additive model (GAM), the associations between ozone and cardiovascular and respiratory diseases causing mortality were analyzed, adjusted for meteorological factors and other major air pollutants including fine particulate matter (PM2.5), nitrogen dioxide (NO2) and carbon monoxide (CO), and stratified by lag, age, and gender. The results showed that, during 2013, ozone was the second main air pollutant in Shenzhen apart from PM2.5, with average daily concentrations of 95.9 µg/m3 and 76.8 µg/m3 for the ozone 1-h mean and the daily ozone 8-h maximum concentration, respectively. The daily level of ozone had a higher concentration from September to October, and relatively low concentration from May to June. Obviously, a higher concentration was found in central parts of Shenzhen with the largest population, indicating higher risks. The excess risk (ER) percentage of the cardio-respiratory mortality rate showed a clearly accumulative effect at L03, with the highest ER percentage of 1.08 (0.88–1.27) per 10 µg/m3 increase in the ozone 8-h maximum concentration for all the population. Males were found to be more sensitive to ozone compared with females, and the elderly were more susceptible to ozone exposure than younger people.

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Tài liệu tham khảo

Hao, 2015, Ozone, fine particulate matter, and chronic lower respiratory disease mortality in the United States, Am. J. Respir. Crit. Care Med., 192, 337, 10.1164/rccm.201410-1852OC

Peng, 2013, Acute effects of ambient ozone on mortality in Europe and North America: Results from the APHENA study, Air Qual. Atmos. Health, 6, 445, 10.1007/s11869-012-0180-9

Pride, 2015, Association of short-term exposure to ground-level ozone and respiratory outpatient clinic visits in a rural location—Sublette County, Wyoming, 2008–2011, Environ. Res., 137, 1, 10.1016/j.envres.2014.10.033

Shahi, 2014, The effects of air pollution on cardiovascular and respiratory causes of emergency admission, Emergency, 2, 107

Petito, 2015, Providing perspective for interpreting cardiovascular mortality risks associated with ozone exposures, Regul. Toxicol. Pharmacol., 72, 107, 10.1016/j.yrtph.2015.03.009

Arjomandi, 2015, Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects, Am. J. Physiol. Heart Circ. Physiol., 308, H1499, 10.1152/ajpheart.00849.2014

Brook, 2004, Air pollution and cardiovascular disease: A statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association, Circulation, 109, 2655, 10.1161/01.CIR.0000128587.30041.C8

Cole, 2009, Promotion of cardiovascular disease by exposure to the air pollutant ozone, Am. J. Physiol. Lung Cell. Mol. Physiol., 297, L205, 10.1152/ajplung.00187.2009

Devlin, 2012, Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects, Circulation, 126, 104, 10.1161/CIRCULATIONAHA.112.094359

Hazucha, 1989, Mechanism of action of ozone on the human lung, J. Appl. Physiol., 67, 1535, 10.1152/jappl.1989.67.4.1535

The United States Environmental Protection Agency (EPA) (2013). 2013 Final Report Integrated Science Assessment of Ozone and Related Photochemical Oxidants.

Adams, 1987, Effects of ozone exposure at ambient air pollution episode levels on exercise performance, Sports Med., 4, 395, 10.2165/00007256-198704060-00002

Kahle, 2015, Interaction effects of temperature and ozone on lung function and markers of systemic inflammation, coagulation, and fibrinolysis: A crossover study of healthy young volunteers, Environ. Health Perspect., 123, 310, 10.1289/ehp.1307986

Gryparis, 2004, Acute effects of ozone on mortality from the “air pollution and health: A European approach” project, Am. J. Respir. Crit. Care Med., 170, 1080, 10.1164/rccm.200403-333OC

Chen, 2013, Evidence on the impact of sustained exposure to air pollution on life expectancy from China’s Huai River policy, Proc. Natl. Acad. Sci. USA, 110, 12936, 10.1073/pnas.1300018110

Lee, 2015, Short-term exposure to fine and coarse particles and mortality: A multicity time-series study in East Asia, Environ. Pollut., 207, 43, 10.1016/j.envpol.2015.08.036

Wang, 2014, A study of air pollutants influencing life expectancy and longevity from spatial perspective in China, Sci. Total Environ., 487, 57, 10.1016/j.scitotenv.2014.03.142

Xiong, 2015, Fine Particulate Matter Pollution and Hospital Admissions for Respiratory Diseases in Beijing, China, Int. J. Environ. Res. Public Health, 12, 11880, 10.3390/ijerph120911880

Yang, 2014, Acute effect of ambient air pollution on heart failure in Guangzhou, China, Int. J. Cardiol., 177, 436, 10.1016/j.ijcard.2014.09.003

Zhang, 2011, Study on the association between ambient air pollution and daily cardiovascular and respiratory mortality in an urban district of Beijing, Int. J. Environ. Res. Public Health, 8, 2109, 10.3390/ijerph8062109

Zhang, 2011, Time-series studies on air pollution and daily outpatient visits for allergic rhinitis in Beijing, China, Sci. Total Environ., 409, 2486, 10.1016/j.scitotenv.2011.04.007

Anger, 2016, China’s air pollution reduction efforts may result in an increase in surface ozone levels in highly polluted areas, Ambio, 45, 254, 10.1007/s13280-015-0700-6

Bhaskaran, 2013, Time series regression studies in environmental epidemiology, Int. J. Epidemiol., 42, 1187, 10.1093/ije/dyt092

Wood, S. (2006). Gerneralized Additive Models: An Introduction with R, Chapman &Hall/CRC.

Austin, 2015, Ozone trends and their relationship to characteristic weather patterns, J. Expo. Sci. Environ. Epidemiol., 25, 532, 10.1038/jes.2014.45

Zhang, F., Liu, X., Zhou, L., Yu, Y., Wang, L., Lu, J., Wang, W., and Krafft, T. (2016). Spatiotemporal patterns of particulate matter (PM) and associations between PM and mortality in Shenzhen, China. BMC Public Health, 16.

Lacour, S.A., de Monte, M., Diot, P., Brocca, J., Veron, N., Colin, P., and Leblond, V. (2006). Relationship between ozone and temperature during the 2003 heat wave in France: Consequences for health data analysis. BMC Public Health, 6.

Farhat, 2013, Ozone is associated with an increased risk of respiratory exacerbations in patients with cystic fibrosis, Chest, 144, 1186, 10.1378/chest.12-2414

Mudway, 2000, Ozone and the lung: A sensitive issue, Mol. Aspects Med., 21, 1, 10.1016/S0098-2997(00)00003-0

Paffett, 2015, Ozone Inhalation Impairs Coronary Artery Dilation via Intracellular Oxidative Stress: Evidence for Serum-Borne Factors as Drivers of Systemic Toxicity, Toxicol. Sci., 146, 244, 10.1093/toxsci/kfv093

Casimiro, 2011, Short-term association between exposure to ozone and mortality in Oporto, Portugal, Environ. Res., 111, 406, 10.1016/j.envres.2011.01.024

Goudarzi, 2015, Cardiovascular and respiratory mortality attributed to ground-level ozone in Ahvaz, Iran, Environ. Monit. Assess., 187, 487, 10.1007/s10661-015-4674-4

Jia, 2011, Acute effect of ambient ozone on heart rate variability in healthy elderly subjects, J. Expo. Sci. Environ. Epidemiol., 21, 541, 10.1038/jes.2011.18

Xu, 2013, Association between ozone exposure and onset of stroke in Allegheny County, Pennsylvania, USA, 1994–2000, Neuroepidemiology, 41, 2, 10.1159/000345138

Bell, 2014, Who is more affected by ozone pollution? A systematic review and meta-analysis, Am. J. Epidemiol., 180, 15, 10.1093/aje/kwu115

Cabello, 2015, Sex differences in the expression of lung inflammatory mediators in response to ozone, Am. J. Physiol. Lung Cell. Mol. Physiol., 309, L1150, 10.1152/ajplung.00018.2015

Sanderson, M.G. (2003). Effect of Climate Change on Isoprene Emissions and Surface Ozone Levels. Geophys. Res. Lett.

Welty, 2005, Are the Acute Effects of Particulate Matter on Mortality in the National Morbidity, Mortality, and Air Pollution Study the Result of Inadequate Control for Weather and Season? A Sensitivity Analysis using Flexible Distributed Lag Models, Am. J. Epidemiol., 162, 80, 10.1093/aje/kwi157