Spatio-Temporal Regulation of Rac1 Localization and Lamellipodia Dynamics during Epithelial Cell-Cell Adhesion

Developmental Cell - Tập 3 Số 2 - Trang 259-270 - 2002
Jason S. Ehrlich1, Marc D.H. Hansen1, W. James Nelson1
1Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA

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Adams, 1998, Cytomechanics of cadherin-mediated cell-cell adhesion, Curr. Opin. Cell Biol., 10, 572, 10.1016/S0955-0674(98)80031-8

Adams, 1998, Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein, J. Cell Biol., 142, 1105, 10.1083/jcb.142.4.1105

Ahmari, 2000, Assembly of presynaptic active zones from cytoplasmic transport packets, Nat. Neurosci., 3, 445, 10.1038/74814

Akhtar, 2001, RAC1 regulates adherens junctions through endocytosis of E-cadherin, Mol. Biol. Cell, 12, 847, 10.1091/mbc.12.4.847

Akhtar, 2000, Co-localization of Rac1 and E-cadherin in human epidermal keratinocytes, Cell Adhes. Commun., 7, 465, 10.3109/15419060009040304

Allen, 1997, Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages, J. Cell Sci., 110, 707, 10.1242/jcs.110.6.707

Bishop, 2000, Rho GTPases and their effector proteins, Biochem. J., 348, 241, 10.1042/bj3480241

Braga, 1997, The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts, J. Cell Biol., 137, 1421, 10.1083/jcb.137.6.1421

Braga, 2000, Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes, Mol. Biol. Cell, 11, 3703, 10.1091/mbc.11.11.3703

Chamberlain, 2000, Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR, Methods Enzymol., 325, 389, 10.1016/S0076-6879(00)25460-8

Espada, 1999, H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of β-catenin in epidermal keratinocytes, J. Cell Biol., 146, 967, 10.1083/jcb.146.5.967

Farnsworth, 1991, Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP, Mol. Cell. Biol., 11, 4822

Fukata, 2001, Rho-family GTPases in cadherin-mediated cell-cell adhesion, Nat. Rev. Mol. Cell Biol., 2, 887, 10.1038/35103068

Fukata, 1999, Cdc42 and Rac1 regulate the interaction of IQGAP1 with β-catenin, J. Biol. Chem., 274, 26044, 10.1074/jbc.274.37.26044

Gumbiner, 2000, Regulation of cadherin adhesive activity, J. Cell Biol., 148, 399, 10.1083/jcb.148.3.399

Hansen, 2001, Serum-activated assembly and membrane translocation of an endogenous Rac1:effector complex, Curr. Biol., 11, 356, 10.1016/S0960-9822(01)00091-4

Haugh, 2000, Spatial sensing in fibroblasts mediated by 3′ phosphoinositides, J. Cell Biol., 151, 1269, 10.1083/jcb.151.6.1269

Hordijk, 1997, Inhibition of invasion of epithelial cells by Tiam1-Rac signaling, Science, 278, 1464, 10.1126/science.278.5342.1464

Jacinto, 2000, Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure, Curr. Biol., 10, 1420, 10.1016/S0960-9822(00)00796-X

Jou, 1998, Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity, J. Cell Biol., 142, 85, 10.1083/jcb.142.1.85

Jou, 1998, Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases, J. Cell Biol., 142, 101, 10.1083/jcb.142.1.101

Kim, 2000, N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility, J. Cell Biol., 151, 1193, 10.1083/jcb.151.6.1193

Kim, 2000, E-cadherin-mediated cell-cell attachment activates Cdc42, J. Biol. Chem., 275, 36999, 10.1074/jbc.M003430200

Kovacs, 2002, E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts, J. Biol. Chem., 277, 6708, 10.1074/jbc.M109640200

Kraynov, 2000, Localized Rac activation dynamics visualized in living cells, Science, 290, 333, 10.1126/science.290.5490.333

Krendel, 1999, Analysis of actin filament bundle dynamics during contact formation in live epithelial cells, Cell Motil. Cytoskeleton, 43, 296, 10.1002/(SICI)1097-0169(1999)43:4<296::AID-CM3>3.0.CO;2-U

Kuroda, 1998, Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion, Science, 281, 832, 10.1126/science.281.5378.832

Marshall, 2001, Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc γ receptor-mediated phagocytosis, J. Cell Biol., 153, 1369, 10.1083/jcb.153.7.1369

Mochizuki, 2001, Spatio-temporal images of growth-factor-induced activation of Ras and Rap1, Nature, 411, 1065, 10.1038/35082594

Nakagawa, 2001, Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites, J. Cell Sci., 114, 1829, 10.1242/jcs.114.10.1829

Nobes, 1995, Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia, Cell, 81, 53, 10.1016/0092-8674(95)90370-4

Nobes, 1999, Rho GTPases control polarity, protrusion, and adhesion during cell movement, J. Cell Biol., 144, 1235, 10.1083/jcb.144.6.1235

Noren, 2001, Cadherin engagement regulates Rho family GTPases, J. Biol. Chem., 276, 33305, 10.1074/jbc.C100306200

Pece, 1999, Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex, J. Biol. Chem., 274, 19347, 10.1074/jbc.274.27.19347

Ridley, 1992, The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors, Cell, 70, 389, 10.1016/0092-8674(92)90163-7

Ridley, 1992, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling, Cell, 70, 401, 10.1016/0092-8674(92)90164-8

Sander, 1998, Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase, J. Cell Biol., 143, 1385, 10.1083/jcb.143.5.1385

Spaargaren, 1999, Rab5 induces Rac-independent lamellipodia formation and cell migration, Mol. Biol. Cell, 10, 3239, 10.1091/mbc.10.10.3239

Stacey, 1991, Dominant inhibitory Ras mutants selectively inhibit the activity of either cellular or oncogenic Ras, Mol. Cell. Biol., 11, 4053

Subauste, 2000, Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas, J. Biol. Chem., 275, 9725, 10.1074/jbc.275.13.9725

Takaishi, 1997, Regulation of cell-cell adhesion by rac and rho small G proteins in MDCK cells, J. Cell Biol., 139, 1047, 10.1083/jcb.139.4.1047

Vasioukhin, 2001, Actin dynamics and cell-cell adhesion in epithelia, Curr. Opin. Cell Biol., 13, 76, 10.1016/S0955-0674(00)00177-0

Vasioukhin, 2000, Directed actin polymerization is the driving force for epithelial cell-cell adhesion, Cell, 100, 209, 10.1016/S0092-8674(00)81559-7

Watton, 1999, Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction, Curr. Biol., 9, 433, 10.1016/S0960-9822(99)80192-4

West, 2000, Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation, Curr. Biol., 10, 839, 10.1016/S0960-9822(00)00595-9

Woodfield, 2001, The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex, Biochem. J., 360, 335, 10.1042/bj3600335

Yonemura, 1995, Cell-to-cell adherens junction formation and actin filament organization, J. Cell Sci., 108, 127, 10.1242/jcs.108.1.127