Spatially Global Representations in Human Primary Visual Cortex during Working Memory Maintenance

Journal of Neuroscience - Tập 29 Số 48 - Trang 15258-15265 - 2009
Edward F. Ester1, John T. Serences, Edward Awh2
1Department of Psychology University of Oregon Eugene, Oregon 97403, USA
2University of Oregon

Tóm tắt

Recent studies suggest that visual features are stored in working memory (WM) via sensory recruitment or sustained stimulus-specific patterns of activity in cortical regions that encode memoranda. One important question concerns the spatial extent of sensory recruitment. One possibility is that sensory recruitment is restricted to neurons that are retinotopically mapped to the positions occupied by the remembered items. Alternatively, specific feature values could be represented via a spatially global recruitment of neurons that encode the remembered feature, regardless of the retinotopic position of the remembered stimulus. Here, we evaluated these alternatives by requiring subjects to remember the orientation of a grating presented in the left or right visual field. Functional magnetic resonance imaging and multivoxel pattern analysis were then used to examine feature-specific activations in early visual regions during memory maintenance. Activation patterns that discriminated the remembered feature were found in regions of contralateral visual cortex that corresponded to the retinotopic position of the remembered item, as well as in ipsilateral regions that were not retinotopically mapped to the position of the stored stimulus. These results suggest that visual details are held in WM through a spatially global recruitment of early sensory cortex. This spatially global recruitment may enhance memory precision by facilitating robust population coding of the stored information.

Từ khóa


Tài liệu tham khảo

10.1016/S1364-6613(00)01593-X

10.1111/j.1467-9280.2007.01949.x

10.1037/a0015792

10.1126/science.1109676

Boynton, 1996, Linear systems analysis of functional magnetic resonance imaging in human V1, J Neurosci, 16, 4207, 10.1523/JNEUROSCI.16-13-04207.1996

10.1163/156856897X00357

10.1073/pnas.93.24.13494

10.1098/rstb.2007.2086

10.3758/BF03211918

10.1038/369525a0

10.1038/nature07832

10.1126/science.1063736

10.1038/nn1445

10.1037/0278-7393.32.1.58

10.1037/0096-1523.33.1.31

10.1111/j.0963-7214.2005.00323.x

10.1038/nn1444

10.1016/j.cub.2006.04.003

10.1038/nn1790

10.1016/j.cub.2004.04.028

Miller, 1996, Neural mechanisms of visual working memory in prefrontal cortex of the macaque, J Neurosci, 16, 5154, 10.1523/JNEUROSCI.16-16-05154.1996

10.1016/j.tics.2006.07.005

10.1016/j.visres.2007.12.022

10.1038/nrn1603

10.1016/j.tics.2006.10.009

10.1163/156856897X00366

10.1016/j.neuroscience.2005.06.005

10.1038/35039062

10.1146/annurev.neuro.26.041002.131112

10.1038/31235

10.1093/cercor/bhp001

10.1038/nn876

10.1016/j.neuron.2007.06.015

10.1523/JNEUROSCI.4021-07.2007

10.1111/j.1467-9280.2009.02276.x

10.1016/j.neuroimage.2008.07.043

10.1126/science.7754376

10.1523/JNEUROSCI.4657-08.2009

10.1126/science.1060496

10.1038/21176

10.1152/jn.00505.2005

Zaksas, 2001, Motion information is spatially localized in a visual working-memory task, J Neurophysiol, 86, 912, 10.1152/jn.2001.86.2.912

10.1038/nature06860

Thông tin
Thông tin xuất bản

Journal of Neuroscience

Tập 29 Số 48

15258-15265

Thông tin tác giả