Spatial learning in preweanling rats trained in a Morris water maze
Tóm tắt
In three experiments, spatial learning in preweanling rats was examined, using the Morris water maze (MWM). Contrary to previous findings, Experiment 1 revealed that rat pups younger than 20 days of age showed good spatial learning. Experiment 2 revealed that spatial learning in preweanlings was influenced by the nature of the training procedure; a spaced distribution of trials resulted in good spatial learning, but a massed distribution of trials did not. Despite evidence that preweanlings have the capacity for spatial learning, Experiment 3 indicated that they are not as proficient as adults. These results are discussed in terms of procedural variables that may influence MWM performance in immature rats.
Tài liệu tham khảo
Brandeis, R., Brandys, Y., & Yehuda, S. (1989). The use of the Morris water maze in the study of memory and learning. International Journal of Neuroscience, 48, 29–69.
Fanselow, M. S., & Tighe, T. J. (1988). Contextual conditioning with massed versus distributed unconditional stimuli. Journal of Experimental Psychology: Animal Behavior Processes, 14, 187–199.
Houston, J. P. (1991). Fundamentals of learning and memory. New York: Harcourt Brace Jovanovich.
Kail, R., & Spear, N. E. (1984). Comparative perspectives on the development of memory. Hillsdale, NJ: Erlbaum.
McNaughton, B. L., Chen, L. L., & Markus, E. J. (1991). “Dead reckoning,” landmark learning, and the sense of direction: A neuropsychological and computational hypothesis. Journal of Cognitive Neuroscience, 3, 190–202.
Munn, N. L. (1950). Handbook of psychological research on rat. Boston: Houghton Mifflin.
O’Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. Oxford: Oxford University Press, Clarendon Press.
Prasad, M. R., Ramaiah, C., Baldwin, S. A., Kraemer, P. J., & Scheff, S W. (1994). Characterization of lateral cortical impact brain injury in the rat. Manuscript submitted for publication.
Rudy, J. W., & Paylor, R. (1988). Reducing the temporal demands of the Morris place-learning task fails to ameliorate the place-learning impairment of preweanling rats. Psychobiology, 16, 152–156.
Rudy, J. W., Stadler-Morris, S., & Albert, P. (1987). Ontogeny of spatial navigation behaviors in the rat: Dissociation of “proximal”- and “distal”-cue-based behaviors. Behavioral Neuroscience, 101, 62–73.
Smith, D. H., Okiyama, K., Thomas, M., Claussen, B., & McIntosh, T. (1991). Evaluation of memory dysfunction following experimental brain injury using the Morris water maze. Journal of Neurotrauma, 8, 259–269.
Spear, N. E., & Campbell, B. A. (1979). Ontogeny of learning and memory. Hillsdale, NJ: Erlbaum.
Sutherland, R. J., & Rudy, J. W. (1989). Configurai association theory: The role of the hippocampal formation in learning, memory and amnesia. Psychobiology, 17, 129–144.