Spatial gradients controlling spindle assembly

Biochemical Society Transactions - Tập 43 Số 1 - Trang 7-12 - 2015
Lesley N. Weaver1, Claire Walczak2
1Department of Biology, Indiana University, Bloomington, IN 47405, U.S.A.
2Medical Sciences, Indiana University, Bloomington, IN 47405, U.S.A.

Tóm tắt

The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.

Từ khóa


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