Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer

Llovet, 2003, Hepatocellular carcinoma., Lancet, 362, 1907, 10.1016/S0140-6736(03)14964-1

Rubin, 2006, Targeting the Hedgehog pathway in cancer., Nat. Rev. Drug Discov., 5, 1026, 10.1038/nrd2086

Katoh, 2006, Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review)., Int. J. Mol. Med., 18, 1019

Ruiz i Altaba, 2002, Gli and hedgehog in cancer: tumours, embryos and stem cells, Nat. Rev. Cancer, 2, 361, 10.1038/nrc796

Pasca di Magliano, 2003, Hedgehog signalling in cancer formation and maintenance, Nat. Rev. Cancer, 3, 903, 10.1038/nrc1229

Thayer, 2003, Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis., Nature, 425, 851, 10.1038/nature02009

Evangelista, 2006, The hedgehog signaling pathway in cancer, Clin. Cancer Res., 12, 5924, 10.1158/1078-0432.CCR-06-1736

Yang, 2010, Activation of the hedgehog-signaling pathway in human cancer and the clinical implications., Oncogene, 29, 469, 10.1038/onc.2009.392

Sicklick, 2006, Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis., Carcinogenesis, 27, 748, 10.1093/carcin/bgi292

Patil, 2006, Hedgehog signaling in human hepatocellular carcinoma., Cancer Biol. Ther ., 5, 111, 10.4161/cbt.5.1.2379

Huang, 2006, Activation of the hedgehog pathway in human hepatocellular carcinomas., Carcinogenesis, 27, 1334, 10.1093/carcin/bgi378

Karhadkar, 2004, Hedgehog signalling in prostate regeneration, neoplasia and metastasis., Nature, 431, 707, 10.1038/nature02962

Yoo, 2008, Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway., Carcinogenesis, 29, 480, 10.1093/carcin/bgm281

Mori, 2006, Gli-1 expression is associated with lymph node metastasis and tumor progression in esophageal squamous cell carcinoma., Oncology, 70, 378, 10.1159/000098111

Feldmann, 2007, Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers., Cancer Res ., 67, 2187, 10.1158/0008-5472.CAN-06-3281

Nagai, 2008, Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation., Cancer Sci ., 99, 1377, 10.1111/j.1349-7006.2008.00822.x

Liao, 2009, Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis, 30, 131, 10.1093/carcin/bgn230

Vihinen, 2005, Matrix metalloproteinases as therapeutic targets in cancer., Curr. Cancer Drug Targets, 5, 203, 10.2174/1568009053765799

Freije, 2003, Matrix metalloproteinases and tumor progression., Adv. Exp. Med. Biol., 532, 91, 10.1007/978-1-4615-0081-0_9

Chen, 2009, Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: association with MMP-9., Hepatol. Res., 39, 177, 10.1111/j.1872-034X.2008.00449.x

Chen, 2010, FAK is involved in invasion and metastasis of hepatocellular carcinoma., Clin. Exp. Metastasis, 27, 71, 10.1007/s10585-010-9306-3

Chen, 1994, Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase., Proc. Natl. Acad. Sci. U.S.A ., 91, 10148, 10.1073/pnas.91.21.10148

Xia, 2004, Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway., J. Biol. Chem., 279, 33024, 10.1074/jbc.M313265200

Reif, 2003, The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression., J. Biol. Chem ., 278, 8083, 10.1074/jbc.M212927200

Tokunaga, 2008, Deregulation of the Akt pathway in human cancer., Curr. Cancer Drug Targets, 8, 27, 10.2174/156800908783497140

Cheng, 2006, Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway., Oncogene, 25, 7009, 10.1038/sj.onc.1209706

Chung, 2004, Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential., FASEB J., 18, 1123, 10.1096/fj.03-1429fje

Park, 2006, Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways., Cancer Res ., 66, 8511, 10.1158/0008-5472.CAN-05-4340

Huang, 2011, miR-338-3p suppresses invasion of liver cancer cell by targeting smoothened., J. Pathol ., 225, 463, 10.1002/path.2877

Vihinen, 2002, Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets., Int. J. Cancer, 99, 157, 10.1002/ijc.10329

Bode, 1999, Insights into MMP-TIMP interactions., Ann. N. Y. Acad. Sci ., 878, 73, 10.1111/j.1749-6632.1999.tb07675.x

Tian, 2010, PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway., Oncol. Rep., 23, 1593

Elia, 2007, Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways., Biochim. Biophys. Acta, 1773, 1438, 10.1016/j.bbamcr.2007.06.006

Riobó, 2006, Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling., Proc. Natl. Acad. Sci. U.S.A., 103, 4505, 10.1073/pnas.0504337103

Schaller, 2001, Biochemical signals and biological responses elicited by the focal adhesion kinase., Biochim. Biophys. Acta, 1540, 1, 10.1016/S0167-4889(01)00123-9

Schlaepfer, 1999, Signaling through focal adhesion kinase., Prog. Biophys. Mol. Biol ., 71, 435, 10.1016/S0079-6107(98)00052-2

Xie, 2008, Hedgehog signaling pathway: development of antagonists for cancer therapy., Curr. Oncol. Rep., 10, 107, 10.1007/s11912-008-0018-7

Deutsch, 2001, A bipotential precursor population for pancreas and liver within the embryonic endoderm., Development, 128, 871, 10.1242/dev.128.6.871

Giannelli, 2002, Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma., Int. J. Cancer, 97, 425, 10.1002/ijc.1635

Arii, 1996, Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential., Hepatology, 24, 316, 10.1002/hep.510240206

Hayasaka, 1996, Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma., Hepatology, 24, 1058, 10.1002/hep.510240513

Bussink, 2008, Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer., Lancet Oncol., 9, 288, 10.1016/S1470-2045(08)70073-1

Fang, 2007, PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis., Cell. Signal ., 19, 2487, 10.1016/j.cellsig.2007.07.025

Yoo, 2011, Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer., Cancer Res ., 71, 7061, 10.1158/0008-5472.CAN-11-1338

Han, 2007, Role of focal adhesion kinase in human cancer: a potential target for drug discovery., Anticancer. Agents Med. Chem ., 7, 681, 10.2174/187152007784111296

McLean, 2005, The role of focal-adhesion kinase in cancer—a new therapeutic opportunity., Nat. Rev. Cancer, 5, 505, 10.1038/nrc1647

Siesser, 2006, The signaling and biological implications of FAK overexpression in cancer., Clin. Cancer Res., 12, 3233, 10.1158/1078-0432.CCR-06-0456

McLean, 2003, Focal adhesion kinase as a potential target in oncology., Expert Opin. Pharmacother., 4, 227, 10.1517/14656566.4.2.227

van Nimwegen, 2007, Focal adhesion kinase: a potential target in cancer therapy., Biochem. Pharmacol ., 73, 597, 10.1016/j.bcp.2006.08.011