Sonic hedgehog signaling in the postnatal brain

Ribes, 2009, Establishing and interpreting graded sonic hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback, Cold Spring Harbor Perspect Biol, 1, a002014, 10.1101/cshperspect.a002014 Dessaud, 2008, Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network, Development, 135, 2489, 10.1242/dev.009324 Hatton, 2006, N-myc is an essential downstream effector of Shh signaling during both normal and neoplastic cerebellar growth, Cancer Res, 66, 8655, 10.1158/0008-5472.CAN-06-1621 Fuccillo, 2006, Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development, Nat Rev Neurosci, 7, 772, 10.1038/nrn1990 McMahon, 2003, Developmental roles and clinical significance of hedgehog signaling, Curr Top Dev Biol, 53, 1, 10.1016/S0070-2153(03)53002-2 Ho, 2002, Sonic hedgehog in the nervous system: functions, modifications and mechanisms, Curr Opin Neurobiol, 12, 57, 10.1016/S0959-4388(02)00290-8 Rohatgi, 2007, Patched1 regulates hedgehog signaling at the primary cilium, Science, 317, 372, 10.1126/science.1139740 Ahn, 2005, In vivo analysis of quiescent adult neural stem cells responding to sonic hedgehog, Nature, 437, 894, 10.1038/nature03994 Machold, 2003, Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches, Neuron, 39, 937, 10.1016/S0896-6273(03)00561-0 Clement, 2007, HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity, Curr Biol, 17, 165, 10.1016/j.cub.2006.11.033 Palma, 2005, Sonic hedgehog controls stem cell behavior in the postnatal and adult brain, Development, 132, 335, 10.1242/dev.01567 Wang, 2007, Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning, Dev Biol, 305, 460, 10.1016/j.ydbio.2007.02.029 Bowers, 2012, Limb anterior–posterior polarity integrates activator and repressor functions of GLI2 as well as GLI3, Dev Biol, 370, 110, 10.1016/j.ydbio.2012.07.017 Oosterveen, 2013, SoxB1-driven transcriptional network underlies neural-specific interpretation of morphogen signals, Proc Natl Acad Sci USA, 110, 7330, 10.1073/pnas.1220010110 Cohen, 2013, Morphogen interpretation: the transcriptional logic of neural tube patterning, Curr Opin Genet Dev, 23, 423, 10.1016/j.gde.2013.04.003 Peterson, 2012, Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning, Genes Dev, 26, 2802, 10.1101/gad.207142.112 Lee, 2010, Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis, Proc Natl Acad Sci USA, 107, 9736, 10.1073/pnas.1004602107 Xu, 2010, Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates, Neuron, 65, 328, 10.1016/j.neuron.2010.01.004 Himmelstein, 2010, Balanced Shh signaling is required for proper formation and maintenance of dorsal telencephalic midline structures, BMC Dev Biol, 10, 118, 10.1186/1471-213X-10-118 Vokes, 2008, A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb, Genes Dev, 22, 2651, 10.1101/gad.1693008 Alvarez-Medina, 2008, Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression, Development, 135, 237, 10.1242/dev.012054 Xu, 2005, Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon, Development, 132, 4987, 10.1242/dev.02090 Gulacsi, 2006, Shh maintains Nkx2.1 in the MGE by a Gli3-independent mechanism, Cereb Cortex, 16, 189 Fleming, 2013, The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors, Dev Cell, 27, 278, 10.1016/j.devcel.2013.10.008 Schuller, 2008, Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma, Cancer Cell, 14, 123, 10.1016/j.ccr.2008.07.005 Kenney, 2003, Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors, Development, 130, 15, 10.1242/dev.00182 Kenney, 2000, Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors, Mol Cell Biol, 20, 9055, 10.1128/MCB.20.23.9055-9067.2000 Goodrich, 1997, Altered neural cell fates and medulloblastoma in mouse patched mutants, Science, 277, 1109, 10.1126/science.277.5329.1109 Wilson, 2012, Primary cilia and Gli3 activity regulate cerebral cortical size, Dev Neurobiol, 72, 1196, 10.1002/dneu.20985 Wang, 2011, Gli3 is required for maintenance and fate specification of cortical progenitors, J Neurosci, 31, 6440, 10.1523/JNEUROSCI.4892-10.2011 Harwell, 2012, Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation, Neuron, 73, 1116, 10.1016/j.neuron.2012.02.009 Yam, 2009, Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway, Neuron, 62, 349, 10.1016/j.neuron.2009.03.022 Suh, 2009, Signaling in adult neurogenesis, Annu Rev Cell Dev Biol, 25, 253, 10.1146/annurev.cellbio.042308.113256 Ihrie, 2008, Cells in the astroglial lineage are neural stem cells, Cell Tissue Res, 331, 179, 10.1007/s00441-007-0461-z Zhao, 2008, Mechanisms and functional implications of adult neurogenesis, Cell, 132, 645, 10.1016/j.cell.2008.01.033 Rakic, 2002, Adult neurogenesis in mammals: an identity crisis, J Neurosci, 22, 614, 10.1523/JNEUROSCI.22-03-00614.2002 Ihrie, 2011, Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain, Neuron, 70, 674, 10.1016/j.neuron.2011.05.004 Ma, 2009, Adult neural stem cells in the mammalian central nervous system, Cell Res, 19, 672, 10.1038/cr.2009.56 Luskin, 1993, Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone, Neuron, 11, 173, 10.1016/0896-6273(93)90281-U Lois, 1994, Long-distance neuronal migration in the adult mammalian brain, Science, 264, 1145, 10.1126/science.8178174 Doetsch, 1999, Subventricular zone astrocytes are neural stem cells in the adult mammalian brain, Cell, 97, 703, 10.1016/S0092-8674(00)80783-7 Doetsch, 1999, Regeneration of a germinal layer in the adult mammalian brain, Proc Natl Acad Sci USA, 96, 11619, 10.1073/pnas.96.20.11619 Spassky, 2005, Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis, J Neurosci, 25, 10, 10.1523/JNEUROSCI.1108-04.2005 Merkle, 2004, Radial glia give rise to adult neural stem cells in the subventricular zone, Proc Natl Acad Sci USA, 101, 17528, 10.1073/pnas.0407893101 Ming, 2005, Adult neurogenesis in the mammalian central nervous system, Annu Rev Neurosci, 28, 223, 10.1146/annurev.neuro.28.051804.101459 Seri, 2004, Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus, J Comp Neurol, 478, 359, 10.1002/cne.20288 Kempermann, 2003, Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice, Development, 130, 391, 10.1242/dev.00203 Breunig, 2011, Neural stem cells: historical perspective and future prospects, Neuron, 70, 614, 10.1016/j.neuron.2011.05.005 Kriegstein, 2009, The glial nature of embryonic and adult neural stem cells, Annu Rev Neurosci, 32, 149, 10.1146/annurev.neuro.051508.135600 Li, 2013, The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus, Neuron, 78, 658, 10.1016/j.neuron.2013.03.019 Chiang, 1996, Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function, Nature, 383, 407, 10.1038/383407a0 Balordi, 2007, Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons, J Neurosci, 27, 5936, 10.1523/JNEUROSCI.1040-07.2007 Balordi, 2007, Mosaic removal of hedgehog signaling in the adult SVZ reveals that the residual wild-type stem cells have a limited capacity for self-renewal, J Neurosci, 27, 14248, 10.1523/JNEUROSCI.4531-07.2007 Han, 2008, Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells, Nat Neurosci, 11, 277, 10.1038/nn2059 Breunig, 2008, Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling, Proc Natl Acad Sci USA, 105, 13127, 10.1073/pnas.0804558105 Lehtinen, 2011, The cerebrospinal fluid provides a proliferative niche for neural progenitor cells, Neuron, 69, 893, 10.1016/j.neuron.2011.01.023 Lim, 2000, Noggin antagonizes BMP signaling to create a niche for adult neurogenesis, Neuron, 28, 713, 10.1016/S0896-6273(00)00148-3 Sawamoto, 2006, New neurons follow the flow of cerebrospinal fluid in the adult brain, Science, 311, 629, 10.1126/science.1119133 Charytoniuk, 2002, Intrastriatal sonic hedgehog injection increases Patched transcript levels in the adult rat subventricular zone, Eur J Neurosci, 16, 2351, 10.1046/j.1460-9568.2002.02412.x Charytoniuk, 2002, Sonic Hedgehog signalling in the developing and adult brain, J Physiol Paris, 96, 9, 10.1016/S0928-4257(01)00075-4 Traiffort, 1999, Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system, Eur J Neurosci, 11, 3199, 10.1046/j.1460-9568.1999.00777.x Traiffort, 1998, Regional distribution of Sonic Hedgehog, patched, and smoothened mRNA in the adult rat brain, J Neurochem, 70, 1327, 10.1046/j.1471-4159.1998.70031327.x Lai, 2003, Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo, Nat Neurosci, 6, 21, 10.1038/nn983 Ihrie, 2011, Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity, Neuron, 71, 250, 10.1016/j.neuron.2011.05.018 Traiffort, 2001, High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain, Eur J Neurosci, 14, 839, 10.1046/j.0953-816x.2001.01708.x Wallace, 1999, A role for Sonic hedgehog in axon-to-astrocyte signalling in the rodent optic nerve, Development, 126, 2901, 10.1242/dev.126.13.2901 Dakubo, 2008, Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells, Brain Res, 1228, 27, 10.1016/j.brainres.2008.06.058 Gonzalez-Reyes, 2012, Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit, Neuron, 75, 306, 10.1016/j.neuron.2012.05.018 Petrova, 2013, Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions, J Neurosci, 33, 17490, 10.1523/JNEUROSCI.2042-13.2013 Merkle, 2014, Adult neural stem cells in distinct microdomains generate previously unknown interneuron types, Nat Neurosci, 17, 207, 10.1038/nn.3610 Merkle, 2007, Mosaic organization of neural stem cells in the adult brain, Science, 317, 381, 10.1126/science.1144914 Lopez-Juarez, 2013, Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone, Genes Dev, 27, 1272, 10.1101/gad.217539.113 Azim, 2012, 3-Dimensional examination of the adult mouse subventricular zone reveals lineage-specific microdomains, PLoS ONE, 7, e49087, 10.1371/journal.pone.0049087 Young, 2007, Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb, J Neurosci, 27, 8286, 10.1523/JNEUROSCI.0476-07.2007 Kohwi, 2005, Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb, J Neurosci, 25, 6997, 10.1523/JNEUROSCI.1435-05.2005 Kelsch, 2007, Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns, PLoS Biol, 5, e300, 10.1371/journal.pbio.0050300 Vokes, 2007, Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning, Development, 134, 1977, 10.1242/dev.001966 Garcia, 2010, Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain, J Neurosci, 30, 13597, 10.1523/JNEUROSCI.0830-10.2010 Sirko, 2013, Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog [corrected], Cell Stem Cell, 12, 426, 10.1016/j.stem.2013.01.019 Amankulor, 2009, Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation, J Neurosci, 29, 10299, 10.1523/JNEUROSCI.2500-09.2009 Becher, 2008, Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas, Cancer Res, 68, 2241, 10.1158/0008-5472.CAN-07-6350 Sofroniew, 2009, Molecular dissection of reactive astrogliosis and glial scar formation, Trends Neurosci, 32, 638, 10.1016/j.tins.2009.08.002 Ferent, 2013, Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination, J Neurosci, 33, 1759, 10.1523/JNEUROSCI.3334-12.2013 Gruber Filbin, 2013, Coordinate activation of Shh and, PI3K., signaling in PTEN-deficient glioblastoma: new therapeutic, opportunities, Nat Med, 19, 1518, 10.1038/nm.3328 Sarangi, 2009, Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival, Oncogene, 28, 3468, 10.1038/onc.2009.208 Monje, 2011, Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma, Proc Natl Acad Sci USA, 108, 4453, 10.1073/pnas.1101657108 Gibson, 2010, Subtypes of medulloblastoma have distinct developmental origins, Nature, 468, 1095, 10.1038/nature09587 Sanders, 2013, Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning, Nature, 497, 628, 10.1038/nature12157 Kornberg, 2014, Cytonemes as specialized signaling filopodia, Development, 141, 729, 10.1242/dev.086223 Kornberg, 2013, Cytonemes extend their reach, EMBO J, 32, 1658, 10.1038/emboj.2013.115 Ericson, 1997, Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube, Cold Spring Harb Symp Quant Biol, 62, 451, 10.1101/SQB.1997.062.01.053 Cayuso, 2006, The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity, Development, 133, 517, 10.1242/dev.02228 Persson, 2002, Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity, Genes Dev, 16, 2865, 10.1101/gad.243402