Sonic Hedgehog signaling regulates vascular differentiation and function in human CD34 positive cells

Stem Cell Research - Tập 14 - Trang 165-176 - 2015
Kurando Kanaya1, Masaaki2, Teiji Okazaki1, Toru Nakamura3, Miki Horii-Komatsu4, Cantas Alev5, Hiroshi Akimaru5, Atsuhiko Kawamoto4, Hidetoshi Akashi1, Hiroyuki Tanaka1, Michio Asahi2, Takayuki Asahara6
1Department of Surgery, Kurume University School of Medicine, Fukuoka, Japan
2Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Osaka, Japan
3Department of Gastroenterology, Kurume University School of Medicine, Fukuoka, Japan
4Group of Vascular Regeneration Research, Institute of Biomedical Research and Innovation, Kobe, Japan
5RIKEN Center for Developmental Biology, Kobe, Japan
6Department of Regenerative Medicine Science, Tokai University School of Medicine, Kanagawa, Japan

Tài liệu tham khảo

Asahara, 1997, Isolation of putative progenitor endothelial cells for angiogenesis, Science, 275, 964, 10.1126/science.275.5302.964 Asai, 2006, Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling, Circulation, 113, 2413, 10.1161/CIRCULATIONAHA.105.603167 Bhardwaj, 2001, Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation, Nat. Immunol., 2, 172, 10.1038/84282 Blank, 2008, Signaling pathways governing stem-cell fate, Blood, 111, 492, 10.1182/blood-2007-07-075168 Carmeliet, 2005, Common mechanisms of nerve and blood vessel wiring, Nature, 436, 193, 10.1038/nature03875 Cohen, 2003, The hedgehog signaling network, Am. J. Med. Genet. A, 123A, 5, 10.1002/ajmg.a.20495 Ergun, 2011, Vascular wall as a reservoir for different types of stem and progenitor cells, Antioxid. Redox Signal., 15, 981, 10.1089/ars.2010.3507 Ferrari, 2009, Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis, J. Cell. Physiol., 219, 449, 10.1002/jcp.21706 Gordon, 1987, Compartmentalization of a haematopoietic growth factor (GM-CSF) by glycosaminoglycans in the bone marrow microenvironment, Nature, 326, 403, 10.1038/326403a0 Ii, 2005, Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via “imported” nitric oxide synthase activity, Circulation, 111, 1114, 10.1161/01.CIR.0000157144.24888.7E Iwasaki, 2006, Dose-dependent contribution of CD34-positive cell transplantation to concurrent vasculogenesis and cardiomyogenesis for functional regenerative recovery after myocardial infarction, Circulation, 113, 1311, 10.1161/CIRCULATIONAHA.105.541268 Johnson, 1997, Molecular models for vertebrate limb development, Cell, 90, 979, 10.1016/S0092-8674(00)80364-5 Jujo, 2010, CXCR4 blockade augments bone marrow progenitor cell recruitment to the neovasculature and reduces mortality after myocardial infarction, Proc. Natl. Acad. Sci. U. S. A., 107, 11008, 10.1073/pnas.0914248107 Kanda, 2003, Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase, J. Biol. Chem., 278, 8244, 10.1074/jbc.M210635200 Kawamoto, 2009, Intramuscular transplantation of G-CSF-mobilized CD34(+) cells in patients with critical limb ischemia: a phase I/IIa, multicenter, single-blinded, dose-escalation clinical trial, Stem Cells, 27, 2857, 10.1002/stem.207 Korbling, 1995, Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts, Blood, 85, 1659, 10.1182/blood.V85.6.1659.bloodjournal8561659 Kudo, 2003, Autologous transplantation of peripheral blood endothelial progenitor cells (CD34+) for therapeutic angiogenesis in patients with critical limb ischemia, Int. Angiol., 22, 344 Kusano, 2004, Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy, Arterioscler. Thromb. Vasc. Biol., 24, 2102, 10.1161/01.ATV.0000144813.44650.75 Kusano, 2005, Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling, Nat. Med., 11, 1197, 10.1038/nm1313 Link, 1996, Transplantation of allogeneic CD34+ blood cells, Blood, 87, 4903, 10.1182/blood.V87.11.4903.bloodjournal87114903 Losordo, 2011, Intramyocardial, autologous CD34+ cell therapy for refractory angina, Circ. Res., 109, 428, 10.1161/CIRCRESAHA.111.245993 Mackie, 2012, Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction, Circ. Res., 111, 312, 10.1161/CIRCRESAHA.112.266015 Madeddu, 2004, Transplantation of low dose CD34+KDR+ cells promotes vascular and muscular regeneration in ischemic limbs, FASEB J., 18, 1737, 10.1096/fj.04-2192fje Manginas, 2007, Pilot study to evaluate the safety and feasibility of intracoronary CD133(+) and CD133(−) CD34(+) cell therapy in patients with nonviable anterior myocardial infarction, Catheter. Cardiovasc. Interv., 69, 773, 10.1002/ccd.21023 Masuda, 2012, Development of serum-free quality and quantity control culture of colony-forming endothelial progenitor cell for vasculogenesis, Stem Cell Transl. Med., 1, 160, 10.5966/sctm.2011-0023 O, 2011, Efficient nonadhesive ex vivo expansion of early endothelial progenitor cells derived from CD34+ human cord blood fraction for effective therapeutic vascularization, FASEB J., 25, 159, 10.1096/fj.10-162040 Palladino, 2012, Combined therapy with sonic hedgehog gene transfer and bone marrow-derived endothelial progenitor cells enhances angiogenesis and myogenesis in the ischemic skeletal muscle, J. Vasc. Res., 49, 425, 10.1159/000337921 Pola, 2001, The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors, Nat. Med., 7, 706, 10.1038/89083 Pola, 2003, Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia, Circulation, 108, 479, 10.1161/01.CIR.0000080338.60981.FA Rajantie, 2004, Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells, Blood, 104, 2084, 10.1182/blood-2004-01-0336 Renault, 2010, Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells, J. Mol. Cell. Cardiol., 49, 490, 10.1016/j.yjmcc.2010.05.003 Scherz, 2007, Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb, Dev. Biol., 308, 343, 10.1016/j.ydbio.2007.05.030 St-Jacques, 1998, Sonic hedgehog signaling is essential for hair development, Curr. Biol., 8, 1058, 10.1016/S0960-9822(98)70443-9 St-Jacques, 1999, Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation, Genes Dev., 13, 2072, 10.1101/gad.13.16.2072 Sutherland, 1993, CD34 antigen: molecular features and potential clinical applications, Stem Cells, 11, 50, 10.1002/stem.5530110914 Tomblyn, 2007, Difficult stem cell mobilization despite adequate CD34+ cell dose predicts shortened progression free and overall survival after autologous HSCT for lymphoma, Bone Marrow Transplant., 40, 111, 10.1038/sj.bmt.1705708 van Royen, 2002, Exogenous application of transforming growth factor beta 1 stimulates arteriogenesis in the peripheral circulation, FASEB J., 16, 432, 10.1096/fj.01-0563fje Wang, 2010, Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action, Circ. Res., 106, 1904, 10.1161/CIRCRESAHA.110.221762 Yamazaki, 2008, Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells, Cancer Sci., 99, 1131, 10.1111/j.1349-7006.2008.00795.x Zhou, 2007, The therapeutic efficacy for limb ischemia by transplantation of mobilized peripheral blood cells before and after CD34+ cell depletion, Zhonghua Xue Ye Xue Za Zhi, 28, 194