Somatostatin receptor-3 mediated intracellular signaling and apoptosis is regulated by its cytoplasmic terminal

Milligan, 1998, New aspects of G-protein-coupled receptor signalling and regulation, Trends Endocrinol. Metab., 9, 13, 10.1016/S1043-2760(98)00004-6 Pierce, 2002, Seven-transmembrane receptors, Nat. Rev. Mol. Cell Biol., 3, 639, 10.1038/nrm908 Blois, 2009, G-protein-coupled receptor structures were not built in a day, Protein Sci., 18, 1335, 10.1002/pro.165 Milligan, 2009, GPCR theme editorial, Br. J. Pharmacol., 158, 1, 10.1111/j.1476-5381.2009.00422.x Patel, 1999, Somatostatin and its receptor family, Front. Neuroendocrinol., 20, 157, 10.1006/frne.1999.0183 Reubi, 2001, Somatostatin receptor sst1–sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands, Eur. J. Nucl. Med., 28, 836, 10.1007/s002590100541 Rocheville, 2000, Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity, Science, 288, 154, 10.1126/science.288.5463.154 Rocheville, 2000, Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers, J. Biol. Chem., 275, 7862, 10.1074/jbc.275.11.7862 Pfeiffer, 2001, Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst(3) receptor function by heterodimerization with sst(2A), J. Biol. Chem., 276, 14027, 10.1074/jbc.M006084200 Grant, 2004, Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking, J. Biol. Chem., 279, 36179, 10.1074/jbc.M407310200 Grant, 2004, The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors, J. Biol. Chem., 279, 38636, 10.1074/jbc.M406276200 Baragli, 2007, Heterooligomerization of human dopamine receptor 2 and somatostatin receptor 2 co-immunoprecipitation and fluorescence resonance energy transfer analysis, Cell. Signal., 19, 2304, 10.1016/j.cellsig.2007.07.007 Grant, 2009, The role of G-proteins in the dimerisation of human somatostatin receptor types 2 and 5, Regul. Pept. Somvanshi, 2009, C-tail mediated modulation of somatostatin receptor type-4 homo- and heterodimerizations and signaling, Cell. Signal., 21, 1396, 10.1016/j.cellsig.2009.04.007 Terrillon, 2004, Roles of G-protein-coupled receptor dimerization, EMBO Rep., 5, 30, 10.1038/sj.embor.7400052 Prinster, 2005, Heterodimerization of G protein-coupled receptors: specificity and functional significance, Pharmacol. Rev., 57, 289, 10.1124/pr.57.3.1 Grant, 2008, Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization, Mol. Endocrinol., 22, 2278, 10.1210/me.2007-0334 Watt, 2009, Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells, Cell. Signal., 21, 428, 10.1016/j.cellsig.2008.11.012 Nishimoto, 2006, MAPK signalling: ERK5 versus ERK1/2, EMBO Rep., 7, 782, 10.1038/sj.embor.7400755 Lahlou, 2003, sst2 Somatostatin receptor inhibits cell proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 activation, J. Biol. Chem., 278, 39356, 10.1074/jbc.M304524200 Weckbecker, 2003, Opportunities in somatostatin research: biological, chemical and therapeutic aspects, Nat. Rev. Drug Discov., 2, 999, 10.1038/nrd1255 Smalley, 1999, The pivotal role of phosphoinositide-3 kinase in the human somatostatin sst(4) receptor-mediated stimulation of p44/p42 mitogen-activated protein kinase and extracellular acidification, Biochem. Biophys. Res. Commun., 263, 239, 10.1006/bbrc.1999.1351 Lahlou, 2004, Molecular signaling of somatostatin receptors, Ann. NY Acad. Sci., 1014, 121, 10.1196/annals.1294.012 Sellers, 1999, Prolonged activation of extracellular signal-regulated kinase by a protein kinase C-dependent and N17Ras-insensitive mechanism mediates the proliferative response of G(i/o)-coupled somatostatin sst(4) receptors, J. Biol. Chem., 274, 24280, 10.1074/jbc.274.34.24280 Weiss, 1981, Somatostatin can locally inhibit proliferation and differentiation of cartilage and bone precursor cells, Calcif. Tissue Int., 33, 425, 10.1007/BF02409466 Sharma, 1996, Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3, Mol. Endocrinol., 10, 1688 Sharma, 1998, G protein coupled receptor signaled apoptosis is associated with activation of a cation insensitive acidic endonuclease and intracellular acidification, Biochem. Biophys. Res. Commun., 242, 134, 10.1006/bbrc.1997.7933 Sharma, 1999, C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest, Mol. Endocrinol., 13, 82, 10.1210/mend.13.1.0220 Liu, 2000, Caspase-8-mediated intracellular acidification precedes mitochondrial dysfunction in somatostatin-induced apoptosis, J. Biol. Chem., 275, 9244, 10.1074/jbc.275.13.9244 Rohrer, 2000, Identification and characterization of subtype selective somatostatin receptor agonists, J. Physiol. Paris, 94, 211, 10.1016/S0928-4257(00)00215-1 Hukovic, 1996, Agonist-dependent regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation, Endocrinology, 137, 4046, 10.1210/endo.137.9.8756582 Lopez, 1996, Molecular mechanisms of antiproliferative effect of somatostatin: involvement of a tyrosine phosphatase, Metabolism, 45, 14, 10.1016/S0026-0495(96)90071-2 J. Cordoba-Chacon, M.D. Gahete, M. Duran-Prado, A.I. Pozo-Salas, M.M. Malagon, F. Gracia-Navarro, R.D. Kineman, R.M. Luque and J.P. Castano, Identification and characterization of new functional truncated variants of somatostatin receptor subtype 5 in rodents, Cell Mol. Life Sci., 67, 1147–63. Srikant, 1987 Hukovic, 1998, The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization, J. Biol. Chem., 273, 21416, 10.1074/jbc.273.33.21416 Strader, 1995, The family of G-protein-coupled receptors, FASEB J., 9, 745, 10.1096/fasebj.9.9.7601339 Gether, 1993, Binding epitopes for peptide and non-peptide ligands on the NK1 (substance P) receptor, Regul. Pept., 46, 49, 10.1016/0167-0115(93)90011-V Schwartz, 1996, Is there a ‘lock’ for all agonist ‘keys’ in 7TM receptors?, Trends Pharmacol. Sci., 17, 213, 10.1016/0165-6147(96)10017-1 Greenwood, 1997, Ligand binding pocket of the human somatostatin receptor 5: mutational analysis of the extracellular domains, Mol. Pharmacol., 52, 807, 10.1124/mol.52.5.807 Roth, 1997, Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization, J. Biol. Chem., 272, 23769, 10.1074/jbc.272.38.23769 Liu, 2005, Receptor signaling and endocytosis are differentially regulated by somatostatin analogs, Mol. Pharmacol., 68, 90, 10.1124/mol.105.011767 Cescato, 2006, Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists, J. Nucl. Med., 47, 502 Sharif, 2007, Coexpression of somatostatin receptor subtype 5 affects internalization and trafficking of somatostatin receptor subtype 2, Endocrinology, 148, 2095, 10.1210/en.2006-1266 Liu, 2008, Distinct phosphorylation sites in the SST2A somatostatin receptor control internalization, desensitization, and arrestin binding, Mol. Pharmacol., 73, 292, 10.1124/mol.107.038570 Romano, 1996, Metabotropic glutamate receptor 5 is a disulfide-linked dimer, J. Biol. Chem., 271, 28612, 10.1074/jbc.271.45.28612 Bai, 1998, Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells, J. Biol. Chem., 273, 23605, 10.1074/jbc.273.36.23605 Chabry, 1995, Thr-422 and Tyr-424 residues in the carboxyl terminus are critical for the internalization of the rat neurotensin receptor, J. Biol. Chem., 270, 2439, 10.1074/jbc.270.6.2439 Thomas, 1995, Angiotensin II receptor endocytosis involves two distinct regions of the cytoplasmic tail. A role for residues on the hydrophobic face of a putative amphipathic helix, J. Biol. Chem., 270, 22153, 10.1074/jbc.270.38.22153 Jockers, 1996, New molecular and structural determinants involved in beta 2-adrenergic receptor desensitization and sequestration. Delineation using chimeric beta 3/beta 2-adrenergic receptors, J. Biol. Chem., 271, 9355, 10.1074/jbc.271.16.9355 Hipkin, 1997, Agonist-induced desensitization, internalization, and phosphorylation of the sst2A somatostatin receptor, J. Biol. Chem., 272, 13869, 10.1074/jbc.272.21.13869 Venkatesan, 2001, A membrane-proximal basic domain and cysteine cluster in the C-terminal tail of CCR5 constitute a bipartite motif critical for cell surface expression, J. Biol. Chem., 276, 40133, 10.1074/jbc.M105722200 Hukovic, 1999, Agonist-dependent up-regulation of human somatostatin receptor type 1 requires molecular signals in the cytoplasmic C-tail, J. Biol. Chem., 274, 24550, 10.1074/jbc.274.35.24550 Yasuda, 1992, Cloning of a novel somatostatin receptor, SSTR3, coupled to adenylylcyclase, J. Biol. Chem., 267, 20422, 10.1016/S0021-9258(19)88719-7 Barbieri, 2008, Somatostatin receptors 1, 2, and 5 cooperate in the somatostatin inhibition of C6 glioma cell proliferation in vitro via a phosphotyrosine phosphatase-eta-dependent inhibition of extracellularly regulated kinase-1/2, Endocrinology, 149, 4736, 10.1210/en.2007-1762 Nishida, 1993, The MAP kinase cascade is essential for diverse signal transduction pathways, Trends Biochem. Sci., 18, 128, 10.1016/0968-0004(93)90019-J Hubina, 2006, Somatostatin analogues stimulate p27 expression and inhibit the MAP kinase pathway in pituitary tumours, Eur. J. Endocrinol., 155, 371, 10.1530/eje.1.02213 Berra, 1998, The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway, J. Biol. Chem., 273, 10792, 10.1074/jbc.273.17.10792 Hipkin, 1995, Truncation of the C-terminal tail of the follitropin receptor does not impair the agonist- or phorbol ester-induced receptor phosphorylation and uncoupling, J. Biol. Chem., 270, 26683, 10.1074/jbc.270.44.26683 Sun, 2007, When a G protein-coupled receptor does not couple to a G protein, Mol. Biosyst., 3, 849, 10.1039/b706343a Lasfer, 2005, Potent induction of apoptosis in human hepatoma cell lines by targeted cytotoxic somatostatin analogue AN-238, J. Hepatol., 42, 230, 10.1016/j.jhep.2004.10.014 Thangaraju, 1999, Regulation of acidification and apoptosis by SHP-1 and Bcl-2, J. Biol. Chem., 274, 29549, 10.1074/jbc.274.41.29549 Lattuada, 2002, The apoptotic effect of somatostatin analogue SMS 201-995 on human lymphocytes, J. Neuroimmunol., 133, 211, 10.1016/S0165-5728(02)00364-8 Saito, 2005, Arginine residue 155 in the second intracellular loop plays a critical role in rat melanin-concentrating hormone receptor 1 activation, Endocrinology, 146, 3452, 10.1210/en.2005-0115