Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
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Bitan, 2003, Amyloid β-protein (Aβ) assembly: Aβ 40 and Aβ 42 oligomerize through distinct pathways, Proc Natl Acad Sci USA, 100, 330, 10.1073/pnas.222681699
Bitan, 2005, Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays, Methods Mol Biol, 299, 3
Bloodgood, 2007, Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines, Neuron, 53, 249, 10.1016/j.neuron.2006.12.017
Bookheimer, 2000, Patterns of brain activation in people at risk for Alzheimer's disease, N Engl J Med, 343, 450, 10.1056/NEJM200008173430701
Busciglio, 1993, Generation of β-amyloid in the secretory pathway in neuronal and nonneuronal cells, Proc Natl Acad Sci USA, 90, 2092, 10.1073/pnas.90.5.2092
Caughey, 2003, Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders, Annu Rev Neurosci, 26, 267, 10.1146/annurev.neuro.26.010302.081142
Chen, 2002, Alzheimer Amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus, Neurobiol Learn Mem, 77, 354, 10.1006/nlme.2001.4034
Cleary, 1995, Beta-amyloid(1-40) effects on behavior and memory, Brain Res, 682, 69, 10.1016/0006-8993(95)00323-I
Cleary, 2005, Natural oligomers of the amyloid β-protein specifically disrupt cognitive function, Nat Neurosci, 8, 79, 10.1038/nn1372
Cummings, 1996, Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease, Neurobiol Aging, 17, 921, 10.1016/S0197-4580(96)00170-4
Davies, 1987, A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease, J Neurol Sci, 78, 151, 10.1016/0022-510X(87)90057-8
Dodart, 2002, Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model, Nat Neurosci, 5, 452, 10.1038/nn842
Engert, 1999, Dendritic spine changes associated with hippocampal long-term synaptic plasticity, Nature, 399, 66, 10.1038/19978
Enya, 1999, Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging, Am J Pathol, 154, 271, 10.1016/S0002-9440(10)65273-X
Frautschy, 2001, Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology, Neurobiol Aging, 22, 993, 10.1016/S0197-4580(01)00300-1
Funato, 1999, Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation, Am J Pathol, 155, 23, 10.1016/S0002-9440(10)65094-8
Gong, 2003, Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss, Proc Natl Acad Sci USA, 100, 10417, 10.1073/pnas.1834302100
Gravina, 1995, Amyloid β protein (Aβ) in Alzheimer's disease brain, J Biol Chem, 270, 7013, 10.1074/jbc.270.13.7013
Haass, 1992, Amyloid β-peptide is produced by cultured cells during normal metabolism, Nature, 359, 322, 10.1038/359322a0
Hardy, 2002, The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994
Hardy, 1992, Alzheimer's disease: the amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067
Harper, 1997, Observation of metastable Aβ amyloid protofibrils by atomic force microscopy, Chem Biol, 4, 119, 10.1016/S1074-5521(97)90255-6
Hartley, 1999, Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons, J Neurosci, 19, 8876, 10.1523/JNEUROSCI.19-20-08876.1999
Hsieh, 2006, AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss, Neuron, 52, 831, 10.1016/j.neuron.2006.10.035
Iwatsubo, 1994, Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43), Neuron, 13, 45, 10.1016/0896-6273(94)90458-8
Jourdain, 2003, Calcium/calmodulin-dependent protein kinase II contributes to activity-dependent filopodia growth and spine formation, J Neurosci, 23, 10645, 10.1523/JNEUROSCI.23-33-10645.2003
Kawarabayashi, 2004, Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease, J Neurosci, 24, 3801, 10.1523/JNEUROSCI.5543-03.2004
Klein, 2001, Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?, Trends Neurosci, 24, 219, 10.1016/S0166-2236(00)01749-5
Klyubin, 2005, Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo, Nat Med, 11, 556, 10.1038/nm1234
Kotilinek, 2002, Reversible memory loss in a mouse transgenic model of Alzheimer's disease, J Neurosci, 22, 6331, 10.1523/JNEUROSCI.22-15-06331.2002
Lambert, 1998, Diffusible, nonfribrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins, Proc Natl Acad Sci USA, 95, 6448, 10.1073/pnas.95.11.6448
Lashuel, 2002, Neurodegenerative disease: amyloid pores from pathogenic mutations, Nature, 418, 291, 10.1038/418291a
Lesne, 2006, A specific amyloid-beta protein assembly in the brain impairs memory, Nature, 440, 352, 10.1038/nature04533
Maletic-Savatic, 1999, Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity, Science, 283, 1923, 10.1126/science.283.5409.1923
Masliah, 2001, Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease, Neurology, 56, 127, 10.1212/WNL.56.1.127
Matsuzaki, 2004, Structural basis of long-term potentiation in single dendritic spines, Nature, 429, 761, 10.1038/nature02617
McDonald, 1994, Effects of an exogenous beta-amyloid peptide on retention for spatial learning, Behav Neural Biol, 62, 60, 10.1016/S0163-1047(05)80059-7
McLaurin, 2006, Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model, Nat Med, 12, 801, 10.1038/nm1423
McLean, 1999, Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease, Ann Neurol, 46, 860, 10.1002/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M
Mulkey, 1994, Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression, Nature, 369, 486, 10.1038/369486a0
Nagerl, 2004, Bidirectional activity-dependent morphological plasticity in hippocampal neurons, Neuron, 44, 759, 10.1016/j.neuron.2004.11.016
Näslund, 2000, Correlation between elevated levels of amyloid β-peptides in the brain and cognitive decline, JAMA, 283, 1571, 10.1001/jama.283.12.1571
Nicoll, 1999, Expression mechanisms underlying NMDA receptor-dependent long-term potentiation, Ann NY Acad Sci, 868, 515, 10.1111/j.1749-6632.1999.tb11320.x
O’Hare, 1999, Delayed behavioral effects following intrahippocampal injection of aggregated A beta (1-42), Brain Res, 815, 1, 10.1016/S0006-8993(98)01002-6
Petersen, 1999, Mild cognitive impairment: clinical characterization and outcome, Arch Neurol, 56, 303, 10.1001/archneur.56.3.303
Podlisny, 1995, Aggregation of secreted amyloid β-protein into SDS-stable oligomers in cell culture, J Biol Chem, 270, 9564, 10.1074/jbc.270.16.9564
Price, 1999, Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease, Ann Neurol, 45, 358, 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X
Roher, 1996, Morphology and toxicity of Aβ-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease, J Biol Chem, 271, 20631, 10.1074/jbc.271.34.20631
Saido, 1995, Dominant and differential deposition of distinct β-amyloid peptide species, AβN3(p3), in senile plaques, Neuron, 14, 457, 10.1016/0896-6273(95)90301-1
Scheuner, 1996, Secreted amyloid b-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease, Nat Med, 2, 864, 10.1038/nm0896-864
Selkoe, 1991, The molecular pathology of Alzheimer's disease, Neuron, 6, 487, 10.1016/0896-6273(91)90052-2
Seubert, 1992, Isolation and quantitation of soluble Alzheimer's β-peptide from biological fluids, Nature, 359, 325, 10.1038/359325a0
Shankar, 2007, Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway, J Neurosci, 27, 2866, 10.1523/JNEUROSCI.4970-06.2007
Shoji, 1992, Production of the Alzheimer amyloid β protein by normal proteolytic processing, Science, 258, 126, 10.1126/science.1439760
Small, 2000, Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease, Proc Natl Acad Sci USA, 97, 6037, 10.1073/pnas.090106797
Snyder, 2005, Regulation of NMDA receptor trafficking by amyloid-beta, Nature Neurosci, 8, 1051, 10.1038/nn1503
Sweeney, 1997, Intrahippocampal injections of exogenous beta-amyloid induce postdelay errors in an eight-arm radial maze, Neurobiol Learn Mem, 68, 97, 10.1006/nlme.1997.3770
Teplow, 1998, Structural and kinetic features of amyloid beta-protein fibrillogenesis, Amyloid, 5, 121, 10.3109/13506129808995290
Terry, 1991, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann Neurol, 30, 572, 10.1002/ana.410300410
Townsend, 2006, Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers, J Physiol, 572, 477, 10.1113/jphysiol.2005.103754
Townsend, 2007, Soluble amyloid β-protein inhibits specific signal transduction cascds common to the insulin reception pathway, J Biol Chem, 10.1074/jbc.M610390200
Vigo-Pelfrey, 1993, Characterization of β-amyloid peptide from human cerebrospinal fluid, J Neurochem, 61, 1965, 10.1111/j.1471-4159.1993.tb09841.x
Walsh, 2002, Naturally secreted oligomers of the Alzheimer amyloid β-protein potently inhibit hippocampal long-term potentiation in vivo, Nature, 416, 535, 10.1038/416535a
Walsh, 1999, Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates, J Biol Chem, 274, 25945, 10.1074/jbc.274.36.25945
Walsh, 2000, Detection of intracellular oligomers of amyloid β-protein in cells derived from human brain, Biochemistry, 39, 10831, 10.1021/bi001048s
Walsh, 2003, The many faces of Aβ: Structures and activity, Curr Med Chem Immun Endoc Metab Agents, 3, 277, 10.2174/1568013033483311
Walsh, 2005, Certain inhibitors of synthetic Aβ fibrillogenesis block oligomerization of natural Aβ and thereby rescue long term potentiation, J Neurosci, 25, 2455, 10.1523/JNEUROSCI.4391-04.2005
Wang, 1996, The profile of soluble amyloid b protein in cultured cell media. Detection and quantificaiton of amyloid β protein and variants by immunoprecipitation-mass spectrometry, J Biol Chem, 271, 31894, 10.1074/jbc.271.50.31894
Xia, 1997, Enhanced production and oligomerization of the 42-residue amyloid b-protein by Chinese hamster ovary cells stably expressing mutant presenilins, J Biol Chem, 272, 7977, 10.1074/jbc.272.12.7977