Solubility enhancement of cox-2 inhibitors using various solvent systems

AAPS PharmSciTech - Tập 4 Số 3 - Trang 36-44 - 2003
Neelam Seedher1, Sonu Bhatia1
1Department of Chemistry, Panjab University, 160014, Chandigarh, India

Tóm tắt

Từ khóa


Tài liệu tham khảo

Lane NE, Thompson JM. Management of osteoarthritis in the primary-care setting: an evidence-based approach to treatment. Am J Med. 1997;103(6A):25–35.

Needleman P, Isakson PC. The discovery and function of cox-2. J Rheumatol. 1997;24(suppl 49):6–8.

Bolten WW. Scientific rationale for specific inhibition of cox-2. J Rheumatol. 1998;25(suppl 51):2–7.

Depre M, Ehrich E, Van Hecken A, De Lepeleire I, Dallob A, Wong P, Porras A, Gertz BJ, De Schepper PJ. Pharmacokinetics, cox-2 specificity, and tolerability of supratherapeutic doses of rofecoxib in humans. Eur J Clin Pharmacol. 2000;56:167–174.

Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992;89:7384–7388.

Silas S, Clegg DO. Selective cox-2 inhibition. Bull Rheum Dis. 1999,40(2):1–4.

Ran Y, Zhao L, Xu Q, Yalkowsky H. Solubilization of cyclosporin A. AAPS PharmSciTech. 2001;2(1) article 2.

Yalkowsky SH, Roseman TJ. Solubilization of drugs by cosolvents. In: Yalkowsky SH, ed. Techniques of Solubilization of Drugs. Vol 12. New York, NY: Marcel Dekker Inc; 1981:91–134.

Zhao L, Li P, Yalkowsky SH. Solubilization of fluasterone. J Pharm Sci. 1999;88:967–969.

Vavia PR, Adhage NA. Inclusion complexation of nimesulide with ∃-cyclodextrins. Drug Dev Ind Pharm. 1999;25:543–545.

Piel G, Pirotte B, Delneuville I, Neven P, Llabres G, Delarge J, Delattre L. Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysin-cyclodextrin complexes. J Pharm Sci. 1997;86:475–480.

Chowdary KPR, Hymavathi R. Enhancement of dissolution rate of meloxicam. Indian J Pharm Sci. 2001;63(2):150–154.

Baboota S, Agarwal SP. Inclusion complexes of meloxicam with ∃-cyclodextrin. Indian J Pharm Sci. 2002;64(4):408–411.

Wilkinson SG. Alcohols. In: Stoddart JF, ed. Comprehensive Organic Chemistry. Vol. 1. New York, NY: Pergamon Press, 1979;579–706.

Li P, Zhao L, Yalkowsky SH. Combined effect of cosolvent and cyclodextrin on solubilization of non-polar drugs. J Pharm Sci. 1999;88:1107–1111.

Yalkowski SH, Rubino JT. Solubilization of cosolvents 1: organic solutes in propylene glycol-water mixtures. J Pharm Sci. 1985;74:416–421.

Etman MA, Salama RO, Shamsedeen MA, El-Kamal A. Indian. J Pharm Sci. 2001;63(6):459–467.

Millard JW, Alvarez-Nunez FA, Yalkowsky SH. Int J Pharm. 2002;245:153–166.

Krishna G, Hodnick WF, Lang W, Lin X, Karra S, Mao J, Almassian B. Pharmaceutical development and manufacturing of a parenteral formulation of a novel antitumor agent, VNP 40101M. AAPS PharmSciTech 2001;2(3) article 14.

Powell M, Nguyen T, Baloian L. Compendium of excipients for parenteral formulations. PDA J Pharm Sci Technol. 1998;52:238–311.

Mottu F, Laurent A, Rufenacht D, Doelker E. Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data. PDA J Pharm Sci Technol. 2000;54:456–469.