Solid Lipid Nanoparticles for the Nucleic Acid Encapsulation
Tóm tắt
We report the formation of lipid nanoparticles (LNPs) capable to encapsulate up to 70% of added DNA molecules and stable within 2.5 weeks. The novelty of the suggested approach is in the components used for nanoparticle formation. The standard components of LNPs are amine, phospholipid, cholesterol and lipid conjugated with poly(ethyleneglycol) (PEGylated). We suggested to combine two components – cholesterol and PEGylated lipid. Thus, studied LNPs contained three components: PEGylated cholesterol, oleylamine and three types of phosphocholine differed in alkyl chain length.
Tài liệu tham khảo
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