Sodium pyruvate reduces hypoxic–ischemic injury to neonatal rat brain

Pediatric Research - Tập 72 Số 5 - Trang 479-489 - 2012
Ying Xu1, Zhihui Rong1, Yun She2, Yuan Cao3, Li-Wen Chang1, Wei-Hua Lee2
1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
2Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana
3Department of General Surgery, Pu Ai Hospital of Wuhan City, Hubei, China

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Graham EM, Ruis KA, Hartman AL, Northington FJ, Fox HE . A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy. Am J Obstet Gynecol 2008;199:587-95.

Verklan MT . The chilling details: hypoxic-ischemic encephalopathy. J Perinat Neonatal Nurs 2009;23:59–68; quiz 69–70.

Perlman JM . Intervention strategies for neonatal hypoxic-ischemic cerebral injury. Clin Ther 2006;28:1353–65.

Geddes R, Vannucci RC, Vannucci SJ . Delayed cerebral atrophy following moderate hypoxia-ischemia in the immature rat. Dev Neurosci 2001;23:180–5.

Northington FJ, Chavez-Valdez R, Martin LJ . Neuronal cell death in neonatal hypoxia-ischemia. Ann Neurol 2011;69:743–58.

Hagberg H, Mallard C, Rousset CI, Xiaoyang Wang . Apoptotic mechanisms in the immature brain: involvement of mitochondria. J Child Neurol 2009;24:1141–6.

Ferriero DM . Neonatal brain injury. N Engl J Med 2004;351:1985–95.

Blomgren K, Hagberg H . Free radicals, mitochondria, and hypoxia-ischemia in the developing brain. Free Radic Biol Med 2006;40:388–97.

Martín A, Rojas S, Pérez-Asensio F, Planas AM . Transient benefits but lack of protection by sodium pyruvate after 2-hour middle cerebral artery occlusion in the rat. Brain Res 2009;1272:45–51.

Moro N, Sutton RL . Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat. Exp Neurol 2010;225:391–401.

Fukushima M, Lee SM, Moro N, Hovda DA, Sutton RL . Metabolic and histologic effects of sodium pyruvate treatment in the rat after cortical contusion injury. J Neurotrauma 2009;26:1095–110.

Lee JY, Kim YH, Koh JY . Protection by pyruvate against transient forebrain ischemia in rats. J Neurosci 2001;21:RC171.

Moro N, Ghavim SS, Hovda DA, Sutton RL . Delayed sodium pyruvate treatment improves working memory following experimental traumatic brain injury. Neurosci Lett 2011;491:158–62.

Zhou D, Qian J, Chang H, Xi B, Sun RP . Pyruvate administered to newborn rats with insulin-induced hypoglycemic brain injury reduces neuronal death and cognitive impairment. Eur J Pediatr 2012; 17:103–9.

Yi JS, Kim TY, Kyu Kim D, Koh JY . Systemic pyruvate administration markedly reduces infarcts and motor deficits in rat models of transient and permanent focal cerebral ischemia. Neurobiol Dis 2007;26:94–104.

Desagher S, Glowinski J, Prémont J . Pyruvate protects neurons against hydrogen peroxide-induced toxicity. J Neurosci 1997;17:9060–7.

Mazzio E, Soliman KF . Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro. Neurosci Lett 2003;337:77–80.

Lee YJ, Kang IJ, Bünger R, Kang YH . Mechanisms of pyruvate inhibition of oxidant-induced apoptosis in human endothelial cells. Microvasc Res 2003;66:91–101.

Shen H, Hu X, Liu C, et al. Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms. Neurobiol Dis 2010;37:711–22.

Rice JE 3rd, Vannucci RC, Brierley JB . The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 1981;9:131–41.

Linseman DA, Phelps RA, Bouchard RJ, et al. Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 2002;22:9287–97.

Matsuzaki H, Tamatani M, Mitsuda N, et al. Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J Neurochem 1999;73:2037–46.

Jagtap JC, Chandele A, Chopde BA, Shastry P . Sodium pyruvate protects against H(2)O(2) mediated apoptosis in human neuroblastoma cell line-SK-N-MC. J Chem Neuroanat 2003;26:109–18.

Kim JB, Yu YM, Kim SW, Lee JK . Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain. Brain Res 2005;1060:188–92.

Redell JB, Moore AN, Dash PK . Expression of the prodynorphin gene after experimental brain injury and its role in behavioral dysfunction. Exp Biol Med (Maywood) 2003;228:261–9.

Liu C, Lin N, Wu B, Qiu Y . Neuroprotective effect of memantine combined with topiramate in hypoxic-ischemic brain injury. Brain Res 2009;1282:173–82.

Amsel A . Hippocampal function in the rat: cognitive mapping or vicarious trial and error? Hippocampus 1993;3:251–6.

Chen W, Ma Q, Suzuki H, Hartman R, Tang J, Zhang JH . Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke 2011;42:764–9.

Kumral A, Uysal N, Tugyan K, et al. Erythropoietin improves long-term spatial memory deficits and brain injury following neonatal hypoxia-ischemia in rats. Behav Brain Res 2004;153:77–86.

Vorhees CV, Williams MT . Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 2006;1:848–58.

Desagher S, Martinou JC . Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000;10:369–77.

Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL . The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 1998;273:7770–5.

Jürgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC . Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 1998;95:4997–5002.

Eskes R, Antonsson B, Osen-Sand A, et al. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J Cell Biol 1998;143:217–24.

Cao G, Minami M, Pei W, et al. Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death. J Cereb Blood Flow Metab 2001;21:321–33.

Zhong J, Zhao L, Du Y, Wei G, Yao WG, Lee WH . Delayed IGF-1 treatment reduced long-term hypoxia-ischemia-induced brain damage and improved behavior recovery of immature rats. Neurol Res 2009;31:483–9.

Zhong J, Deng J, Huang S, Yang X, Lee WH . High K+ and IGF-1 protect cerebellar granule neurons via distinct signaling pathways. J Neurosci Res 2004;75:794–806.

Wei X, Du Z, Zhao L, et al. IFATS collection: The conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 2009;27:478–88.

Shi Q, Zhang P, Zhang J, et al. Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci Lett 2009;465:220–5.