So sánh hai phương pháp tạo đám hoại tử (PFU) và liều gây nhiễm 50% tế bào nuôi cấy (CCID<sub>50</sub>) trong xác định hiệu giá vắc xin sởi dự tuyển mẫu chuẩn quốc gia
Tóm tắt
A comparative study of two methods (PFU and CCID50) for potency determination for the national standard candidate measles vaccine was organized at the National Institute for Control of Vaccines and Biologicals (NICVB). Two methods are performed on the groups of candidate measles vaccine derived from AIK-C strain stored at different temperatures: -70oC, 4oC/7 days, 37oC/7 days. The results show that although there is a difference, strong correlation exists between the two methods CCID50 and PFU with R2 = 0.886, r = 0.94, coefficient PFU/ CCID50 = 1.28 equivalent to the ratio PFU: CCID50 = 1:0.78